Addendum to 1‐Butanol (n‐Butyl alcohol)
Assessment Values in Biological Material – Translation of the German version from 2016
Wobbeke Weistenhöfer1Gabriele Leng2
Hans Drexler1 (Head of the working group “Assessment Values in Biological Material” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Andrea Hartwig3 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission4
1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Schillerstraße 25 and 29, 91054 Erlangen, Germany
2 Currenta GmbH & Co. OHG, CUR-SIT-SER-GS-BLM – Institute for Biomonitoring, Kaiser-Wilhelm-Allee 80, 51368 Leverkusen, Germany
3 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Germany
4 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the BAT values (biological tolerance values) for 1‐butanol.
A capillary gas chromatographic head space technique developed by the Working Group “Analyses in Biological Materials” of the German Research Foundation (DFG) was used for determining 1‐butanol in urine. For this method hydrolysis is recommended neither for blood nor for urine investigation.
The BAT values of 10 mg 1‐butanol/g creatinine (sampling time at the end of exposure or end of shift) and 2 mg 1‐butanol/g creatinine (sampling time 16 hours after the end of shift (at the beginning of the next shift)) related to the MAK value of 100 ml/m3 were confirmed.
