N‑Methylanilin
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) re-evaluated the data for developmental toxicity for N-methylaniline [100-61-8]. In humans, the critical effect of N-methylaniline, as with aniline, is the formation of methaemoglobin (MetHb). A recent prenatal developmental toxicity study according to OECD test guideline 414 in rats shows an increased number of preimplantation losses and early resorptions per litter and a reduced number of live male and female foetuses per litter. The NOAEL of 0.8 mg/kg body weight and day extrapolated to a concentration in air is lower than the maximum concentration at the workplace (MAK value) of 0.5 ml/m3. Therefore, N-methylaniline is assigned to Pregnancy Risk Group B (“According to currently available information damage to the embryo or foetus cannot be excluded after exposure to concentrations at the level of the MAK and BAT values”) at a MAK value of 0.5 ml/m3.
