Cyclohexylamin
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for cyclohexylamine.
A 4‐hour inhalation study with volunteers showed clear irritation at 10 ml/m3, whereas a time‐weighted average concentration of 2 ml/m3 with peaks of up to 4 ml/m3 was without impact on sensory irritation parameters and neurobehavioral measurements. The MAK value of 2 ml/m3 and classification in Peak Limitation Category I has been retained. No irritation was observed up to 4 ml/m3; therefore, the excursion factor 2 has been retained as well. As cyclohexylamine is a strong base and 10 ml/m3 is clearly irritating, a momentary value of 5 ml/m3 is set.
