Adipinsäure
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated adipic acid to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints.
The critical effect is moderate local irritation as shown with the Draize test in the rabbit eye. Available inhalation studies are limited and not suitable to derive a MAK value. Systemic toxicity only occurs at high doses. In a limited oral 2‐year study the body weight of rats was reduced at 2250 mg/kg body weight/day. The resulting systemic NOAEL is 750 mg/kg body weight/day.
After comparing adipic acid with other solid acids, a MAK value of 2 mg adipic acid/m3 I has been set in analogy to phosphoric acid, which is considered to be the worst‐case.
As the critical effect is local, adipic acid is assigned to Peak Limitation Category I. In analogy to phosphoric acid, a default excursion factor of 2 is set.
There is no reason to fear damage to the embryo or foetus when the MAK value is observed; thus, the substance is classified in Pregnancy Risk Group C.
Adipic acid is not genotoxic and not carcinogenic. No contact sensitizing effects have been observed. Skin contact is not expected to contribute significantly to systemic toxicity.
