2-Butoxyethylacetat
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) re-evaluated the assignment of 2-butoxyethyl acetate [112-07-2] to Pregnancy Risk Group C (“Damage to the embryo or foetus is unlikely if the MAK value or the BAT value is observed.”). No developmental toxicity studies are available for 2-butoxyethyl acetate. As the substance is rapidly metabolised to acetic acid and 2-butoxyethanol, for which more data are available, 2-butoxyethyl acetate is assessed in analogy. It is assumed that the developmental toxic effects of 2-butoxyethanol in rats are almost exclusively due to the haemolysis caused by its metabolite butoxyacetic acid. Taking into account the increased respiratory volume at the work place and the lower sensitivity of humans compared to rats for the haemolytic effect, the margin between the NOAEC for developmental toxicity and the MAK value of 10 ml/m3 is sufficient. Thus, 2-butoxyethanol has been assigned to Pregnancy Risk Group C and by analogy, the assignment to Pregnancy Risk Group C has been confirmed for 2-butoxyethyl acetate at the MAK value of 10 ml/m3.
