Naphtha (Erdöl), mit Wasserstoff behandelte schwere
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and re-evaluated the data for the derivation of the occupational exposure limit value (maximum concentration at the workplace, MAK value) for naphtha (petroleum), hydrotreated heavy [64742-48-9]. The critical effect is preclinical neurotoxicity. The results of a 13-week study with an isoparaffinic product in rats and a behavioural toxicity study in volunteers do not contradict the previous MAK value of 50 ml/m3. The assignment to Peak Limitation Category II with an excursion factor of 2 is retained. Additionally, there are no experimental data showing that juvenile animals are more sensitive to naphtha-induced neurotoxic effects than adults. Therefore, there is no evidence that would require changing the previous categorization from Pregnancy Risk Group D to Pregnancy Risk Group B (suspected prenatal toxicity).
