N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amin
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine [91273‐04‐0] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is corrosive to the skin of rabbits and results in irritation of the stomach after gavage administration in rats. Therefore, a local irritation potential is to be assumed. There are no inhalation studies availabe and no read‐across substance could be found. Thus, a MAK value could not be derived and the substance is classified in Section II b of the List of MAK and BAT Values. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is not genotoxic. Carcinogenicity studies are not available. Maximization tests in guinea pigs reveal a skin sensitizing potential and the substance is designated with „Sh“. Skin contact is not expected to contribute significantly to systemic toxicity.
