Manifesto (MAK value/classification)

The irritant effect, which is less pronounced than that of 2-butoxyethanol, is assumed to be the most relevant effect in humans.

Carcinogenicity.

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References

[1] ECHA (European Chemicals Agency) (2018) 2-Butoxyethyl acetate (CAS Number 112-07-2). Registration dossier. Joint submission, first publication 03 Mar 2013, last modification 29 May 2018. https://echa.europa.eu/de/registration-dossier/-/registered-dossier/16067, accessed 30 Jul 2018
[2] Greim H (ed) (2001) 2-Butoxyethylacetat. In: Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten, 33rd issue. Wiley-VCH, Weinheim. Also available from DOI: 10.1002/3527600418.mb11207d0033
[3] Greim H (ed) (2008) 2-Butoxyethylacetat. In: Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten, 44th issue. Wiley-VCH, Weinheim. Also available from DOI: 10.1002/3527600418.mb11207d0044
[4] Hartwig A, MAK Commission (2019) 2-Butoxyethanol (Ethylene glycol monobutyl ether). MAK Value Documentation, 2018. MAK Collect Occup Health Saf 4(1): 20–35. DOI: 10.1002/3527600418.mb11176e6419
[5] Henschler D (ed) (1993) 2-Butoxyethyl acetate. MAK Value Documentation, 1984. In: Occupational Toxicants, vol 6. VCH, Weinheim. Also available from DOI: 10.1002/3527600418.mb11207e0006
[6] Jacobs G, Martens M, Mosselmans G (1987) Proposal of limit concentrations for skin irritation within the context of a new EEC directive on the classification and labeling of preparations. Regul Toxicol Pharmacol 7(4): 370–378. DOI: 10.1016/0273-2300(87)90057-2
[7] Jacobs GA, Castellazzi A, Dierickx PJ (1989) Evaluation of a non-invasive human and an in vitro cytotoxicity method as alternatives to the skin irritation test on rabbits. Contact Dermatitis 21(4): 239–244. DOI: 10.1111/j.1600-0536.1989.tb03202.x
[8] OECD (Organization for Economic Co-operation and Development) (2017) Test No. 460: Fluorescein leakage test method for identifying ocular corrosives and severe irritants, OECD guidelines for the testing of chemicals, section 4. OECD Publishing, Paris. DOI: 10.1787/9789264185401-en