<?xml version="1.0" encoding="iso-8859-1" standalone="no"?>
<GmsArticle>
  <MetaData>
    <Identifier>000177</Identifier>
    <IdentifierDoi>10.3205/000177</IdentifierDoi>
    <IdentifierUrn>urn:nbn:de:0183-0001778</IdentifierUrn>
    <ArticleType language="en">Review Article</ArticleType>
    <ArticleType language="de">&#220;bersichtsarbeit</ArticleType>
    <TitleGroup>
      <Title language="en">The German quality indicators in intensive care medicine 2013 &#8211; second edition</Title>
      <TitleTranslated language="de">Intensivmedizinische Qualit&#228;tsindikatoren f&#252;r Deutschland 2013 &#8211; zweite Auflage</TitleTranslated>
    </TitleGroup>
    <CreatorList>
      <Creator>
        <PersonNames>
          <Lastname>Braun</Lastname>
          <LastnameHeading>Braun</LastnameHeading>
          <Firstname>Jan-Peter</Firstname>
          <Initials>JP</Initials>
          <AcademicTitle>PD Dr. med.</AcademicTitle>
        </PersonNames>
        <Address language="en">Department of Anesthesiology and Intensive Care Medicine, Campus Charit&#233; Mitte and Campus Virchow-Klinikum, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Charit&#233; Centrum 7, Charit&#233;platz 1, 10117 Berlin, Germany, Phone: 0049 30 450531012<Affiliation>Department of Anesthesiology and Intensive Care Medicine, Campus Charit&#233; Mitte and Campus Virchow-Klinikum, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Germany</Affiliation></Address>
        <Address language="de">Klinik f&#252;r An&#228;sthesiologie mit Schwerpunkt operative Intensivmedizin, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Charit&#233; Centrum 7, Charit&#233;platz 1, 10117 Berlin, Deutschland, Tel.: 0049 30 450531012<Affiliation>Klinik f&#252;r An&#228;sthesiologie mit Schwerpunkt operative Intensivmedizin, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Deutschland</Affiliation></Address>
        <Email>jan.braun&#64;charite.de</Email>
        <Creatorrole corresponding="yes" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Kumpf</Lastname>
          <LastnameHeading>Kumpf</LastnameHeading>
          <Firstname>Oliver</Firstname>
          <Initials>O</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anesthesiology and Intensive Care Medicine, Campus Charit&#233; Mitte and Campus Virchow-Klinikum, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie mit Schwerpunkt operative Intensivmedizin, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Deja</Lastname>
          <LastnameHeading>Deja</LastnameHeading>
          <Firstname>Maria</Firstname>
          <Initials>M</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anesthesiology and Intensive Care Medicine, Campus Charit&#233; Mitte and Campus Virchow-Klinikum, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie mit Schwerpunkt operative Intensivmedizin, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Brinkmann</Lastname>
          <LastnameHeading>Brinkmann</LastnameHeading>
          <Firstname>Alexander</Firstname>
          <Initials>A</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anaesthesiology and Intensive Care Medicine, Klinikum Heidenheim, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie und Intensivmedizin, Klinikum Heidenheim, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Marx</Lastname>
          <LastnameHeading>Marx</LastnameHeading>
          <Firstname>Gernot</Firstname>
          <Initials>G</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Intensive Care Medicine, Universit&#228;tsklinikum RTWH Aachen, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r Intensivmedizin, Universit&#228;tsklinikum RWTH Aachen, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Bloos</Lastname>
          <LastnameHeading>Bloos</LastnameHeading>
          <Firstname>Frank</Firstname>
          <Initials>F</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie und Intensivtherapie, Universit&#228;tsklinikum Jena, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Kaltwasser</Lastname>
          <LastnameHeading>Kaltwasser</LastnameHeading>
          <Firstname>Arnold</Firstname>
          <Initials>A</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>German Society of Special Nursing (DGF), Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Deutsche Gesellschaft f&#252;r Fachkrankenpflege (DGF), Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Dubb</Lastname>
          <LastnameHeading>Dubb</LastnameHeading>
          <Firstname>Rolf</Firstname>
          <Initials>R</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>German Society of Special Nursing (DGF), Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Deutsche Gesellschaft f&#252;r Fachkrankenpflege (DGF), Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Muhl</Lastname>
          <LastnameHeading>Muhl</LastnameHeading>
          <Firstname>Elke</Firstname>
          <Initials>E</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Surgery, Medical University of Schleswig Holstein, Luebeck, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r Chirurgie, Universit&#228;tsklinikum Schleswig Holstein, Campus L&#252;beck, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Greim</Lastname>
          <LastnameHeading>Greim</LastnameHeading>
          <Firstname>Clemens</Firstname>
          <Initials>C</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anaesthesiology and Intensive Care Medicine, Klinikum Fulda, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie und operative Intensivmedizin, Klinikum Fulda, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Bause</Lastname>
          <LastnameHeading>Bause</LastnameHeading>
          <Firstname>Hanswerner</Firstname>
          <Initials>H</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Quality Committee of the State Chamber of physicians Hamburg, previous Department of Anaesthesiology and Intensive Care Medicine, Asklepiosklinikum Altona, Hamburg, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Qualit&#228;tsausschuss &#196;rztekammer Hamburg, ehemals Klinik f&#252;r An&#228;sthesiologie und operative Intensivmedizin, Asklepiosklinikum Altona, Hamburg, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Weiler</Lastname>
          <LastnameHeading>Weiler</LastnameHeading>
          <Firstname>Norbert</Firstname>
          <Initials>N</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anaesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie und Intensivmedizin, Universit&#228;tsklinikum Schleswig Holstein, Kiel, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Chop</Lastname>
          <LastnameHeading>Chop</LastnameHeading>
          <Firstname>Ines</Firstname>
          <Initials>I</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>German Medical Association, Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Bundes&#228;rztekammer, Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Waydhas</Lastname>
          <LastnameHeading>Waydhas</LastnameHeading>
          <Firstname>Christian</Firstname>
          <Initials>C</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Trauma and Reconstructive Surgery, University Hospital Essen, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r Unfall- und Wiederherstellungschirurgie, Universit&#228;tsklinikum Essen, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
      <Creator>
        <PersonNames>
          <Lastname>Spies</Lastname>
          <LastnameHeading>Spies</LastnameHeading>
          <Firstname>Claudia</Firstname>
          <Initials>C</Initials>
        </PersonNames>
        <Address language="en">
          <Affiliation>Department of Anesthesiology and Intensive Care Medicine, Campus Charit&#233; Mitte and Campus Virchow-Klinikum, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Germany</Affiliation>
        </Address>
        <Address language="de">
          <Affiliation>Klinik f&#252;r An&#228;sthesiologie mit Schwerpunkt operative Intensivmedizin, Charit&#233; &#8211; Universit&#228;tsmedizin Berlin, Deutschland</Affiliation>
        </Address>
        <Creatorrole corresponding="no" presenting="no">author</Creatorrole>
      </Creator>
    </CreatorList>
    <PublisherList>
      <Publisher>
        <Corporation>
          <Corporatename>German Medical Science GMS Publishing House</Corporatename>
        </Corporation>
        <Address>D&#252;sseldorf</Address>
      </Publisher>
    </PublisherList>
    <SubjectGroup>
      <SubjectheadingDDB>610</SubjectheadingDDB>
      <Keyword language="en">quality management</Keyword>
      <Keyword language="en">intensive care medicine</Keyword>
      <Keyword language="en">quality indicators</Keyword>
      <Keyword language="en">peer review</Keyword>
      <Keyword language="de">Qualit&#228;tsmanagement</Keyword>
      <Keyword language="de">Intensivmedizin</Keyword>
      <Keyword language="de">Peer Review</Keyword>
      <Keyword language="de">Qualit&#228;tsindikatoren</Keyword>
    </SubjectGroup>
    <DateReceived>20130624</DateReceived>
    <DatePublishedList>
      
    <DatePublished>20130716</DatePublished><DateRepublished>20130717</DateRepublished></DatePublishedList>
    <Language>engl</Language>
    <LanguageTranslation>germ</LanguageTranslation>
    <SourceGroup>
      <Journal>
        <ISSN>1612-3174</ISSN>
        <Volume>11</Volume>
        <JournalTitle>GMS German Medical Science</JournalTitle>
        <JournalTitleAbbr>GMS Ger Med Sci</JournalTitleAbbr>
      </Journal>
    </SourceGroup>
    <ArticleNo>09</ArticleNo>
    <Correction><DateLastCorrection>20130717</DateLastCorrection>PDF with attachments</Correction>
  </MetaData>
  <OrigData>
    <Abstract language="de" linked="yes"><Pgraph>Qualit&#228;tsindikatoren sind elementare Bestandteile des Qualit&#228;tsmanagements. Die Qualit&#228;tsindikatoren f&#252;r die Intensivmedizin der Deutschen Interndisziplin&#228;ren Vereinigung f&#252;r Intensivmedizin (DIVI) aus dem Jahre 2010 sind nun im Rahmen der geplanten Geltungsdauer &#252;berarbeitet und angepasst worden. Insgesamt wurde ein Indikator ersetzt und drei weitere zum Teil wesentlich &#252;berarbeitet. Der alte Indikator I &#8222;Oberk&#246;rperhochlagerung&#8220; wurde durch den Indikator &#8222;T&#228;gliche multiprofessionelle, klinische Visite mit Dokumentation von Tageszielen&#8220; ersetzt und in den neu geschaffenen Indikator IV &#8222;Weaning und Ma&#223;nahmen zur Vermeidung von ventilatorassoziierten Pneumonien (kurz: Weaning&#47;VAP Bundle)&#8220; (VAP &#61; ventilator-assoziierte Pneumonie) integriert, der auf ein Verringerung der VAP-Inzidenz abzielt. Der Indikator VIII &#8222;Dokumentation von strukturierten Angeh&#246;rigengespr&#228;chen&#8220; wurde weiter pr&#228;zisiert. Der Indikator X &#8222;Leitung der Intensivstation durch einen Facharzt mit Zusatzbezeichnung Intensivmedizin, der keine anderen klinischen Aufgaben hat&#8220; anhand der aktuellen Studienlage ebenfalls pr&#228;zisiert. Die aktualisierten Qualit&#228;tsindikatoren sind Bestandteil der intensivmedizinischen Peer Reviews. Ihre n&#228;chste Aktualisierung ist f&#252;r das Jahr 2016 geplant. </Pgraph></Abstract>
    <Abstract language="en" linked="yes"><Pgraph>Quality indicators are key elements of quality management. The quality indicators for intensive care medicine of the German Interdisciplinary Society of Intensive Care Medicine (DIVI) from the year 2010 were recently evaluated when their validity time expired after two years. Overall one indicator was replaced and further three were in part changed. The former indicator I &#8220;elevation of head of bed&#8221; was replaced by the indic<TextGroup><PlainText>ator</PlainText></TextGroup> &#8220;Daily multi-professional ward rounds with the documentation of daily therapy goals&#8221; and added to the indicator IV &#8220;Weaning and other measures to prevent ventilator associated pneumonias (short: Weaning&#47;VAP Bundle)&#8221; (VAP &#61; ventilator-associated pneumonia) which aims at the reduction of VAP incidence. The indicator VIII &#8220;Documentation of structured relative-&#47;next-of-kin communication&#8221; was refined.  The indic<TextGroup><PlainText>ator</PlainText></TextGroup> X &#8220;Direction of the ICU by a specially trained certified intensivist with no other clinical duties in a department&#8221; was also updated according to recent study results. These updated quality indicators are part of the Peer Review in intensive care medicine. The next update of the quality indicators is due in 2016.</Pgraph></Abstract>
    <TextBlock language="en" linked="yes" name="Introduction">
      <MainHeadline>Introduction</MainHeadline><Pgraph>Planned for a validity period of two years in 2010, the first version of the German quality indicators in intensive care medicine has been published <TextLink reference="1"></TextLink>. This was the first time that quality indicators for surgical and medical ICUs have been developed. The acceptance of these indicators was broad. Congresses and meetings showed great <TextGroup><PlainText>inte</PlainText></TextGroup>rest to introduce these indicators and spread their implementation. The results of an increasing number of peer reviews in intensive care medicine are showing a high degree of implementation of these indicators in different ICUs. These indicators therefore fulfil the requirements stated in the RUMBA-rule:</Pgraph><Pgraph><UnorderedList><ListItem level="1"><Mark1>R</Mark1>elevant for a problem</ListItem><ListItem level="1"><Mark1>U</Mark1>nderstandable </ListItem><ListItem level="1"><Mark1>M</Mark1>easurable, with good validity and reliability</ListItem><ListItem level="1"><Mark1>B</Mark1>ehaviourable </ListItem><ListItem level="1"><Mark1>A</Mark1>chievable and feasible </ListItem></UnorderedList></Pgraph><Pgraph>The quality indicators in intensive care medicine changed the day-to-day routine care in ICUs in Germany. Limiting the number of indicators to ten for easier and better handling may have contributed to their implementation. Furthermore especially core processes of routine care in intensive care medicine are represented like ventilator therapy, antiinfective therapy as well as analgesia, sedation and management of delirium, nutrition, hygiene, controlled hypothermia and management of relatives. Staffing of the ICU is used as a structural indicator.</Pgraph><Pgraph>The pretension of these quality indicators in intensive care medicine is to introduce a high level of performance quality. Without measurement of quality there is no chance of detecting change. In a French study a score system for implementation of quality dimensions was developed and consecutively used in a network of ICUs. They showed that the median degree of translation of quality dimensions reached around 60&#37; where the best units reached up to 80&#37; <TextLink reference="2"></TextLink>. </Pgraph><Pgraph>When assuming that every intensive care physician has the intention to organize intensive care medicine in the best interest of his patients then all measures to optimize care have to be highly welcome. This aim has to be in the centre of interest when developing quality indicators.</Pgraph></TextBlock>
    <TextBlock language="de" linked="yes" name="Einleitung">
      <MainHeadline>Einleitung</MainHeadline><Pgraph>F&#252;r eine G&#252;ltigkeit von 2 Jahren wurde 2010 die erste Version der intensivmedizinischen Qualit&#228;tsindikatoren f&#252;r Deutschland publiziert <TextLink reference="1"></TextLink>. Damit war es erstmals gelungen, Qualit&#228;tsindikatoren f&#252;r die operativen und konservativen intensivmedizinischen Bereiche in Deutschland zu erarbeiten. Die Akzeptanz der Qualit&#228;tsindikatoren ist sehr gro&#223;. Auf den intensivmedizinischen Kongressen ist das Interesse an den Qualit&#228;tsindikatoren und deren Umsetzung im Alltag anhaltend gewachsen. Die Erfahrungen aus den intensivmedizinischen Peer Reviews zeigen, dass die Qualit&#228;tsindikatoren einen hohen Umsetzungsgrad auf den Intensivstationen haben. Dies sind Belege daf&#252;r, dass die Qualit&#228;tsindikatoren die Anforderungen der RUMBA-Regel erf&#252;llen:</Pgraph><Pgraph><UnorderedList><ListItem level="1"><Mark1>R</Mark1>elevant f&#252;r das Problem</ListItem><ListItem level="1"><Mark1>U</Mark1>nderstandable (verst&#228;ndlich formuliert)</ListItem><ListItem level="1"><Mark1>M</Mark1>essbar sein, mit hoher Zuverl&#228;ssigkeit und G&#252;ltigkeit</ListItem><ListItem level="1"><Mark1>B</Mark1>ehaviourable (ver&#228;nderbar durch das Verhalten)</ListItem><ListItem level="1"><Mark1>A</Mark1>chievable and feasible (Erreichbar und durchf&#252;hrbar)</ListItem></UnorderedList></Pgraph><Pgraph>Die intensivmedizinischen Qualit&#228;tsindikatoren haben den Alltag auf den Intensivstationen qualitativ ver&#228;ndert. Das mag zum einen daran liegen, dass die Zahl der Qualit&#228;tsindikatoren auf eine handhabbare Gr&#246;&#223;e von zehn begrenzt wurde, zum anderen mag ein Vorteil der intensivmedizinischen Qualit&#228;tsindikatoren darin liegen, dass die Kernprozesse des intensivmedizinischen Alltag darin abgebildet werden: Beatmung, antiinfektive Therapie, Analgesie, Sedierung und Delir-Behandlung, Ern&#228;hrung, Hygiene, kontrollierte Hypothermie, und Angeh&#246;rigenmanagement. Ferner findet sich das Strukturkriterium der Personalbesetzung einer Intensivstation als Indikator wieder. </Pgraph><Pgraph>Gelebte Qualit&#228;t zu f&#246;rdern bleibt der Anspruch der intensivmedizinischen Qualit&#228;tsindikatoren. Ohne die Messbarkeiten von Qualit&#228;ten lassen sich Ver&#228;nderungen nicht darstellen. Franz&#246;sische Kollegen konnten anhand eines Score-Systems darstellen, welchen Umsetzungsgrad von verschiedenen Qualit&#228;tsdimensionen sie auf franz&#246;sischen Intensivstationen evaluiert haben <TextLink reference="2"></TextLink>. Die Autoren stellen dabei fest, dass im Median diese Qualit&#228;ten zu ca. 60&#37; umgesetzt waren, wobei die jeweils besten Intensivstationen bezogen auf die untersuchten Qualit&#228;ten etwa einen Erf&#252;llungsgrad von ca. 80&#37; hatten. </Pgraph><Pgraph>Wenn man bei jedem Intensivmediziner die Intention voraussetzt, im Patienteninteresse, die Intensivmedizin bestm&#246;glich zu organisieren, dann sind Ma&#223;nahmen, die dazu f&#252;hren, die Patientenversorgung auf Intensivstationen zu optimieren, h&#246;chst willkommen. Dieses Ziel muss man bei der Erstellung von Qualit&#228;tsindikatoren vor Augen haben.</Pgraph></TextBlock>
    <TextBlock language="en" linked="yes" name="International comparison of quality indicators in intensive care medicine">
      <MainHeadline>International comparison of quality indicators in intensive care medicine</MainHeadline><Pgraph>A Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM) published a list of indicators for improvement of quality and safety in intensive care medicine <TextLink reference="3"></TextLink>. A five round Delphi-process with an agreement rate of at least 90&#37; yielded the following indicators: <LineBreak></LineBreak><LineBreak></LineBreak>Structural indicators </Pgraph><Pgraph><UnorderedList><ListItem level="1">The intensive care unit fulfils national requirements to provide intensive care</ListItem><ListItem level="1">24-h availability of a consultant level intensivist </ListItem><ListItem level="1">Adverse event reporting-system</ListItem></UnorderedList></Pgraph><Pgraph>Process indicators</Pgraph><Pgraph><UnorderedList><ListItem level="1">Presence of routine multi-disciplinary clinical ward rounds </ListItem><ListItem level="1">Standardized hand-over procedure for patients discharge</ListItem></UnorderedList></Pgraph><Pgraph>Outcome-indicators</Pgraph><Pgraph><UnorderedList><ListItem level="1">Reporting and analysis of standardised mortality ratio (SMR)</ListItem><ListItem level="1">ICU re-admission rate within 48 h of ICU discharge</ListItem><ListItem level="1">Rate of central venous catheter-related blood stream infection</ListItem><ListItem level="1">Rate of unplanned endotracheal extubations </ListItem></UnorderedList></Pgraph><Pgraph>These European quality- and safety indicators describe common problems or events. However, for example SMR is included in the Core data set (Kerndatensatz) of the German Interdisziplinary Society of Intensive Care Medicine (DIVI) and registration of catheter-associated blood stream infections is achieved by Krankenhaus-Infektions-Surveillance-System (<Mark1>KISS</Mark1>) (<Hyperlink href="http:&#47;&#47;www.nrz-hygiene.de&#47;surveillance&#47;kiss&#47;">http:&#47;&#47;www.nrz-hygiene.de&#47;surveillance&#47;kiss&#47;</Hyperlink>).  Prerequisite for taking part in those surveillance systems is the technical ability of data transfer which &#8211; due to the lack of uniform technical standards &#8211; is problematic in many hospitals. Furthermore, it can be problematic to measure the rate of unplanned extubations because of the increasing use of non-invasive ventilatory support and the newly developed guidelines for sedation. If avoidance of unplanned extubation is a goal then in turn deeper sedation might be the consequence with other unfavourable outcomes instead. </Pgraph><Pgraph>We do not intend to diminish the relevance of these <TextGroup><PlainText>ind</PlainText></TextGroup>icators with our critique. They give an important impulse for the further development of the German intensive care quality indicators. Additionally redundant indicators had to be avoided and hence more outcome related indicators are covered by different systems.</Pgraph><Pgraph>The first version of German quality indicators for intensive care medicine 2010 has been criticised to be biased towards process indicators. This comparison of seven other European countries with ICU quality indicators showed more presence of outcome indicators like the standardized mortality ratio (SMR), rate of re-intubation, patient satisfaction, rate of readmission to the ICU, duration of ventilation or bed occupancy rate <TextLink reference="4"></TextLink>. Different national health care systems set different framework requirements for intensive care medicine. A part of the European outcome indicators are covered by alternative quality monit<TextGroup><PlainText>oring</PlainText></TextGroup> systems. For example the intensive care core data set (DIVI-REVERSI) covers SMR or 48-hour readmission rate. Adverse event indicators like &#8220;rate of pressure ulcers&#8221; are main indicators of the BQS in German hospitals. Incidence of nosocomial infection like catheter-related bloodstream infections or ventilator-associated pneumonias are present in the Hospital Infections Surveillance System (Krankenhaus Infektions Surveillance System, KISS). </Pgraph><Pgraph>The German quality indicators in intensive care medicine should be seen in the context of other measures and systems of quality improvement but overall they are only one part of quality improvement in intensive care. However redundancies with other measures and systems should be avoided. It is an explicit strength of these indic<TextGroup><PlainText>ators</PlainText></TextGroup> that their implementation is rather unproblematic and not depending on large scale structural changes except the willingness to change daily routine in intensive care. These indicators may help with a self-assessment by the participating acting groups as well as by external assessment through peer review <TextLink reference="5"></TextLink>, <TextLink reference="6"></TextLink>. It is the main intention of these quality indicators to represent core processes in intensive care medicine to change the quality of intensive care medicine according to the most recent evidence based principles to bring good practice to the patients&#8217; bedside <TextLink reference="1"></TextLink>.</Pgraph></TextBlock>
    <TextBlock language="de" linked="yes" name="Intensivmedizinische Qualit&#228;tsindikatoren im internationalen Vergleich">
      <MainHeadline>Intensivmedizinische Qualit&#228;tsindikatoren im internationalen Vergleich</MainHeadline><Pgraph>Eine Task Force on Safety and Quality der European Society of Intensive Care Medicine (ESICM) hat 2012 eine Liste von Indikatoren zur Verbesserung von Patientensicherheit und Qualit&#228;t in der Intensivmedizin publiziert <TextLink reference="3"></TextLink>. Nach f&#252;nf Runden eines Delphi-Verfahrens hat man sich unter der Ma&#223;gabe eines mindestens 90&#37;igen Konsensus auf folgende Indikatoren geeinigt:<LineBreak></LineBreak><LineBreak></LineBreak>Strukturindikatoren</Pgraph><Pgraph><UnorderedList><ListItem level="1">Die Intensivstation erf&#252;llt nationale Standards der Intensivmedizin </ListItem><ListItem level="1">24-st&#252;ndige Verf&#252;gbarkeit eines Fach-&#47;Oberarztes mit Bezeichnung Intensivmedizin</ListItem><ListItem level="1">Ein &#8222;adverse event&#8220;-Reporting-System</ListItem></UnorderedList></Pgraph><Pgraph>Prozessindikatoren</Pgraph><Pgraph><UnorderedList><ListItem level="1">Multidisziplin&#228;re Visiten auf der Intensivstation in der Routine</ListItem><ListItem level="1">Standardisiertes Verfahren (inklusive standardisierter Dokumentation) zur &#220;berleitung von intensivmedizinischen Patienten auf Normalstationsbereiche. </ListItem></UnorderedList></Pgraph><Pgraph>Outcome-Indikatoren</Pgraph><Pgraph><UnorderedList><ListItem level="1">Report der standardisierten Mortalis&#228;tsrate (SMR)</ListItem><ListItem level="1">48-st&#252;ndige Wiederaufnahmerate von Normalstation zur&#252;ck auf eine Intensivstation</ListItem><ListItem level="1">Rate der katheterassoziierten Blutstrominfektionen</ListItem><ListItem level="1">Rate der ungeplanten Extubationen</ListItem></UnorderedList></Pgraph><Pgraph>Diese Europ&#228;ischen Qualit&#228;ts- und Sicherheitsindikatoren beschreiben durchweg allt&#228;gliche Probleme bzw. Ereignisse. Bezogen auf deutsche intensivmedizinische Verh&#228;ltnisse werden die SMR oder die 48 h-Wiederaufnahmerate im intensivmedizinischen Kerndatensatz der DIVI erfasst. Die Registrierung von katheterassoziierten Blutstrominfektionen ist u.a. Gegenstand des Krankenhaus-Infektions-Surveillance-Systems (<Mark1>KISS</Mark1>) (<Hyperlink href="http:&#47;&#47;www.nrz-hygiene.de&#47;surveillance&#47;kiss&#47;">http:&#47;&#47;www.nrz-hygiene.de&#47;surveillance&#47;kiss&#47;</Hyperlink>). Die Teilnahme an solchen Surveillance-Systemen setzt nat&#252;rlich auch die technischen &#220;bertragungsm&#246;glichkeiten der Daten voraus, was mangels einheitlicher Standards in Krankenh&#228;usern per se h&#228;ufig als Problem genannt wird.  Die Rate der ungeplanten Extubationen erscheint in der t&#228;glichen Messung technisch ebenfalls problembehaftet, zumal bei Zunahme von nicht-invasiven Beatmungen und unter Anwendung der Analgosedierungsleitlinien die Semantik des Begriffes &#8222;ungeplant&#8220; nicht unkritisch zu bewerten ist. So darf es nicht Ziel einer Kennzahl &#8222;ungeplante Extubation&#8220; sein, die Patienten wieder tief zu sedieren. </Pgraph><Pgraph>Es soll die Bedeutung der europ&#228;ischen Indikatoren mit diesen kurzen Anmerkungen nicht geschm&#228;lert werden. Inhaltlich setzen diese Indikatoren Impulse f&#252;r die Neuauflage der deutschen intensivmedizinischen Qualit&#228;tsindikatoren. Eine Redundanz von Kennzahlen, die aus unterschiedlichen Systemen in Deutschland erhoben werden, soll mit den Qualit&#228;tsindikatoren ebenfalls vermieden werden. </Pgraph><Pgraph>F&#252;r die deutschen intensivmedizinischen Qualit&#228;tsindikatoren der ersten Version von 2010 gilt folgendes: Im internationalen Vergleich sind die Prozessindikatoren in Deutschland &#8222;&#252;berrepr&#228;sentiert&#8220;. Im Vergleich mit sieben L&#228;ndern, die ebenfalls Qualit&#228;tsindikatoren in der Intensivmedizin erarbeitet haben, werden haupts&#228;chlich Ergebnisindikatoren aufgef&#252;hrt, wie z.B. standardisierte Mortalit&#228;tsrate (SMR), Reintubationsrate, Patientenzufriedenheit, Wideraufnahmerate, Beatmungsdauer oder Bettenbelegungsrate. Dagegen bilden sich in den deutschen intensivmedizinischen Qualit&#228;tsindikatoren eher Prozesse ab <TextLink reference="4"></TextLink>. Die Gesundheitssysteme in verschiedenen L&#228;ndern bieten der Intensivmedizin unterschiedliche Rahmenbedingungen. Die in den Qualit&#228;tsindikatorenlisten unserer europ&#228;ischen Nachbarl&#228;nder enthaltenen Outcome-Indikatoren sind beispielsweise zum Teil Gegenstand des deutschen intensivmedizinischen Kerndatensatzes (SMR und 48 h-Wiederaufnahmerate). Der &#8222;adverse event&#8220;-Indikator &#8222;Dekubitus-Rate&#8220; wird als Generalindikator der Bundesgesch&#228;ftsstelle Qualit&#228;tssicherung gGmbH (BQS) bereits in den deutschen Krankenh&#228;usern abgebildet. Inzidenz von nosokomialen Infektionen wie i.v.-Katheterinfektionen oder ventilatorassoziierten Pneumonien (VAP) sind Gegenstand der o.g. nationalen Surveillance-Systeme (KISS).  </Pgraph><Pgraph>Die deutschen intensivmedizinischen Qualit&#228;tsindikatoren sind im Kontext gemeinsam mit anderen qualit&#228;tsverbessernden Verfahren und Systemen zu sehen und stellen bei dem gro&#223;en Thema der Qualit&#228;tsverbesserung der intensivmedizinischen Versorgung der Patienten nur einen Teilaspekt dar. Redundanz mit bestehenden qualit&#228;tssichernden Systemen soll vermieden werden. Im pragmatischen Sinne muss es daher explizit als St&#228;rke der deutschen Qualit&#228;tsindikatoren genannt werden, dass die Umsetzung der Qualit&#228;tsindikatoren auf den Intensivstationen unproblematisch und an keine tiefgreifenden Strukturver&#228;nderungen gekn&#252;pft ist, au&#223;er der Bereitschaft der Akteure, den intensivmedizinischen Alltag qualitativ zu ver&#228;ndern. Die Selbstbewertung wird durch die Qualit&#228;tsindikatoren erm&#246;glicht ebenso wie die Fremdbewertung durch externe Peer Reviewer <TextLink reference="5"></TextLink>, <TextLink reference="6"></TextLink>. Es  bleibt die Kernintention der Qualit&#228;tsindikatoren, die intensivmedizinischen Kernprozesse entsprechend der aktuellen intensivmedizinischen Evidenzlage zu ver&#228;ndern, damit evidenzbasierte &#8222;good practice&#8220; schneller den Weg an das Krankenbett findet <TextLink reference="1"></TextLink>. </Pgraph></TextBlock>
    <TextBlock language="en" linked="yes" name="Development of the second edition of quality indicators for the ICU">
      <MainHeadline>Development of the second edition of quality indicators for the ICU</MainHeadline><Pgraph>Scientific evidence changes over time and therefore it is necessary to check the validity of science based quality indicators for improving outcomes of patient care. The National Steering Committee for peer review in intensive care medicine has been assigned by the DIVI to revise these indicators over a two-year cycle. One main goal was to keep the number of indicators at ten to avoid impracticability. In May of 2012 the revision process of the quality indicators in intensive care medicine started. Firstly, the medical societies involved in intensive care medicine, which are organized in the DIVI, were asked via their scientific working groups to revise the quality indicators. In November 2012 the proposals of the scientific committees were assembled. In December all proposals were discussed and a renewed version of the indicators was presented to the medical societies by means of the Delphi-method. In April 2013 no more proposals for change were recorded and the Executive Committee of the DIVI formally approved the quality <TextGroup><PlainText>ind</PlainText></TextGroup>icators for intensive care medicine for publication. </Pgraph></TextBlock>
    <TextBlock language="de" linked="yes" name="Erstellung der zweiten Version der intensivmedizinischen Qualit&#228;tsindikatoren">
      <MainHeadline>Erstellung der zweiten Version der intensivmedizinischen Qualit&#228;tsindikatoren</MainHeadline><Pgraph>Da sich die wissenschaftliche Evidenz mit der Zeit ver&#228;ndert, ist es notwendig, dass auch die Qualit&#228;tsindikatoren regelm&#228;&#223;ig einer Pr&#252;fung unterzogen werden hinsichtlich ihrer G&#252;ltigkeit, der Verbesserung des Patienten-Outcomes zu dienen. Der nationalen Steuerungsgruppe f&#252;r das intensivmedizinische Peer Review System ist durch die DIVI hierbei die Rolle zugeteilt worden, die &#220;berarbeitung der intensivmedizinischen Qualit&#228;tsindikatoren in einem regelm&#228;&#223;igen zweij&#228;hrigen Zyklus redaktionell zu &#252;bernehmen. Der Auftrag beinhaltete, die Zahl der bisherigen zehn Indikatoren nicht zu &#252;berschreiten, um die Praktikabilit&#228;t im Alltag nicht durch eine gro&#223;e Zahl von Indikatoren zu behindern. Im Mai 2012 hat die Steuerungsgruppe begonnen das Verfahren der &#220;berarbeitung der intensivmedizinischen Qualit&#228;tsindikatoren zu organisieren. Zun&#228;chst wurden die in der DIVI organisierten Fachgesellschaften angeschrieben mit der Bitte in den jeweiligen wissenschaftlichen Arbeitskreisen die Bearbeitung der Qualit&#228;tsindikatoren zu &#252;bernehmen. Im November 2012 wurden die Vorschl&#228;ge aus den Fachgesellschaften zusammengetragen. Im Dezember wurde diese neue Vorschlagsliste &#252;berarbeitet und anschlie&#223;end in einer weiteren Delphirunde erneut zur &#220;berarbeitung vorgelegt. Im April wurden keine weiteren &#196;nderungen mehr registriert. Die zweite Auflage der intensivmedizinischen Qualit&#228;tsindikatoren wurde im Mai 2013 durch Pr&#228;sidiumsbeschluss der DIVI best&#228;tigt und die Freigabe zur Publikation erteilt. </Pgraph></TextBlock>
    <TextBlock language="en" linked="yes" name="The newly developed QI">
      <MainHeadline>The newly developed QI</MainHeadline><Pgraph>An explanatory comment accompanies each indicator as it has been done in the first version of the German quality indicators for intensive care medicine. In Attachment 1 <AttachmentLink attachmentNo="1"/> all indicators are presented in their final consented version.</Pgraph><SubHeadline>QI I &#8211; Daily multi-professional ward rounds with the documentation of daily therapy goals</SubHeadline><Pgraph>Determining daily goals in the multiprofessional ICU team, consisting at least of nurses and physicians of a ward, has been first published in 2003 by Pronovost et al <TextLink reference="7"></TextLink>. Since then, several other authors have published about this topic. The original &#8220;daily goal form&#8221; of the Johns Hopkins Hospital in Baltimore, MD, USA is now widely used and has been modified to be included into clinical routine in different regions and countries all over the world. The agreement over daily goals in a patient has been shown to improve communication in the caring team, increases transparency of treatment goals and improves patient safety with a positive effect on outcome. </Pgraph><Pgraph>Establishing this new QI in German ICUs will have substantial impact on daily routine. The routine documentation, either paper based or electronically, needs to be adapted. This will lead to greater transparency and achievement of daily goals will be measured more easily. Such a change in daily routine needs the attentiveness of all professions involved in critical care medicine. The authors recommend the initiation of projects to achieve this change. The suppliers of commercially available documentation systems are asked to offer solutions for process implementation of daily goals sheets. </Pgraph><SubHeadline>QI II &#8211; Monitoring sedation, analgesia, delirium</SubHeadline><Pgraph>The QI II has not been changed. No new evidence regarding this topic has been published. The S3-Guideline is still in effect <TextLink reference="8"></TextLink>. Preliminary unpublished data from peer reviews show potential for improvement in this field in intensive care medicine. </Pgraph><SubHeadline>QI III &#8211; Lung protective ventilation</SubHeadline><Pgraph>As fort he QI II the evidence situation for this QI is also unchanged. However, the implementation in clinical routine is still unsatisfactory. The discrepancy between theoretical knowledge and actual bedside use has been repeatedly published <TextLink reference="9"></TextLink>. </Pgraph><SubHeadline>QI IV &#8211; Weaning and other measures to prevent ventilator associated pneumonias </SubHeadline><Pgraph>The most extensive modification of the indicators took part in the QI IV. Both, the former QI I (Elevation of upper body) as well as the former QI IV (Weaning) aimed at the reduction of the incidence of ventilator associated pneumonias (VAP). VAP is of utmost importance in intensive care medicine. Avoidance of VAP has become a central quality indicator in the USA. Even financial compensation for this complication has been questioned recently to increase pressure to introduce quality improvement measures. </Pgraph><Pgraph>The positive effect of weaning on VAP incidence is mainly based on the time factor involved. The faster weaning from mechanical ventilation can be achieved the lower is the probability of VAP. However weaning is a complex process strongly linked to sedation concepts. Guideline based analgo-sedation is a prerequisite for successful weaning which in consequence is only achieved by a concerted standardized effort. This is one main component in the avoidance of atrophy of respiratory muscles which is a central pathophysiological factor for weaning failure. </Pgraph><Pgraph>The positive effect of elevation of the upper body on the reduction of VAP incidence has recently been questioned. No further study evidence was added and measuring daily compliance is difficult for two reasons:</Pgraph><Pgraph><OrderedList><ListItem level="1" levelPosition="1" numString="1.">Elevation of the upper body more than 30&#176; is only rarely achieved</ListItem><ListItem level="1" levelPosition="2" numString="2.">The necessary duration of elevation is unclear or if it even might interfere with other therapeutic or prophylactic measures (pressure ulcers etc.)</ListItem></OrderedList></Pgraph><Pgraph>This lack of practicability has been seen in many peer reviews. The positive effect of the elevation of the upper body is based in the physical reduction in gastrointestinal reflux&#47;regurgitation resulting in the avoidance of aspira<TextGroup><PlainText>tion.</PlainText></TextGroup> The opposite, lowering the upper body, might also help achieving this particular goal. Minimizing aspiration can be achieved by many other measures, which were recently published. When used as a bundle they proved to be effective in reducing the incidence of VAP. With the view concentrated on outcome, some measures were effective and included in a VAP bundle (Body positioning protocol, hand disinfection before and after manipulating the airways,  Oral hygiene and decontamination (with either antiseptic or antiinfective solutions, avoidance of micro aspiration by measuring cuff pressure, subglottic suctioning etc.). Upper body elevation is then considered one element of the bundle which mainly should emphas<TextGroup><PlainText>ize</PlainText></TextGroup> avoidance of solely flatness. The other measures mentioned in the QI are examples which have been shown to be relevant for patient outcome. </Pgraph><Pgraph>We intended to bring order into the complexity of measures for the incidence of VAP reduction. The authors tried to achieve this by introducing this indicator based on two measurable parts. </Pgraph><Pgraph><OrderedList><ListItem level="1" levelPosition="1" numString="1.">Weaning, measured from the patient file</ListItem><ListItem level="1" levelPosition="2" numString="2.">VAP-bundle, measured from the patient file and nursing documentation.</ListItem></OrderedList></Pgraph><SubHeadline>QI V &#8211; Early and adequate initiation of antibiotic therapy</SubHeadline><Pgraph>This indicator was not changed. The evidence relating to this indicator has basically been the same over the last years. The experience from peer review in intensive care medicine has shown that implementation of sepsis bundles is still a challenge. The recognition of SIRS and signs of infection and consecutively the timely application of antiinfectives are demanding for the organization of an intensive care unit. </Pgraph><Pgraph>Overall the application of antibiotic stewardship programmes in this context is recommended <TextLink reference="10"></TextLink>. The use of data regarding resistance of microbes is of high importance for adequate treatment It is strongly recommended to take part in national surveillance programmes. This has not yet been broadly established <TextLink reference="11"></TextLink>.</Pgraph><SubHeadline>QI VI &#8211; Therapeutic hypothermia after cardiac arrest </SubHeadline><Pgraph>This indicator has not been changed. The European guidelines have additionally been changed with regard to therapeutic hypothermia <TextLink reference="12"></TextLink>. There appears to be a broader consciousness regarding the necessity of neuro-protection following cardiac arrest probably through campaigns featuring this issue. However, the authors think that the evaluation of this indicator might need other tools since patients following cardiac arrest and successful resuscitation are not a large patient group and measures like a peer review on a certain day might not adequately reflect implementation. </Pgraph><SubHeadline>QI VII &#8211; Early enteral nutrition</SubHeadline><Pgraph>This indicator has not been changed. In recent years numerous publications regarding nutrition in intensive care patients have been released. Especially evidence regarding parenteral nutrition has changed. Early enteral nutrition is still the main goal to achieve in intensive care patients. Overall nutrition via the natural route is preferred but also the adequate composition of nutrients and the adequate amount of caloric supply. </Pgraph><SubHeadline>QI VIII &#8211; Documentation of structured relative-&#47;next-of-kin communication</SubHeadline><Pgraph>This indicator has been modified. The results of recent peer reviews showed that documentation of communication with relatives has not been implemented in a satisfactory manner. The main critique was the lack of defini<TextGroup><PlainText>tions</PlainText></TextGroup> of goals for a patient. Especially there was a lack of documented topics addressed in these communications. Furthermore the goals defined in the best interest of the patient&#8217;s will were not routinely defined or sufficiently documented. Therefore it seemed necessary to modify this indicator. Additionally documentation forms&#47;templates should be modified to address these obvious needs. </Pgraph><SubHeadline>QI IX &#8211; Hand disinfectant consumption </SubHeadline><Pgraph>This indicator has not been changed. In daily care, use of hand disinfectants is still insufficient. Therefore, it seemed necessary to focus on this indicator. The peer reviews showed that there is still some inconsistency in the use of this indicator. It is not solely the amount of disinfectant to be counted it is the relation to the amount of staff members of a unit that matters. This is the only reasonable measure for an adequate use of hand disinfectants in an ICU. </Pgraph><SubHeadline>QI X &#8211; Direction of the ICU by a specialist dedicated intensivist with no other clinical duties in a department. Presence of a specialist ICU-physician during daytime and presence of experienced intensive care physicians and nurses over the course of 24 hours a day</SubHeadline><Pgraph>This indicator has been modified according to new strong evidence published recently. Adequate care of ICU patients can only be achieved by the 24&#47;7 presence of a qualified and experienced team of nurses and physicians. Especially in the daytime, when important decisions of all disciplines involved in the care of an individual patient have to be made and all decision-makers are present, the availability of a dedicated intensivist has been proven to improve outcome <TextLink reference="13"></TextLink>. This intensivist doesn&#39;t need to be the head of a unit but most importantly has to be free of other clinical duties outside of the ICU. The head of the ICU should be the head of a distinct department or a leading consultant of a department. This is in accord to the actual demands articulated by the German Interdisciplinary Association for Intensive Care Medicine (Deutsche interdisziplin&#228;re Vereinigung f&#252;r Intensivmed<TextGroup><PlainText>izin</PlainText></TextGroup>, DIVI) This indicator also notes that the nurse-to-patient ratio in all mechanically ventilated patients (including non-invasive ventilation) has at least to be one nurse per two patients.</Pgraph></TextBlock>
    <TextBlock language="de" linked="yes" name="Die neuen intensivmedizinischen Qualit&#228;tsindikatoren f&#252;r Deutschland">
      <MainHeadline>Die neuen intensivmedizinischen Qualit&#228;tsindikatoren f&#252;r Deutschland</MainHeadline><Pgraph>Wie schon bei der Publikation der ersten intensivmedizinischen Qualit&#228;tsindikatoren wird auch in der zweiten Version zu jedem Qualit&#228;tsindikator ein Kommentar pr&#228;sentiert und im Anhang 1 <AttachmentLink attachmentNo="1"/> wird die Liste der derzeit g&#252;ltigen Qualit&#228;tsindikatoren in der Originalversion dargestellt.</Pgraph><SubHeadline>QI I &#8211; T&#228;gliche  multiprofessionelle, klinische Visite mit Dokumentation von Tageszielen&#47;eines Tagesziels</SubHeadline><Pgraph>Die t&#228;gliche Festlegung von Tageszielen im multiprofessionellen Team, welches mindestens aus &#228;rztlichen und pflegerischen Mitarbeitern der Intensivstation besteht wurde erstmals von Pronovost et. al im Jahre 2003 publiziert <TextLink reference="7"></TextLink>. Seither sind einige Publikationen zu diesem Thema erschienen. Die &#8222;daily goal form&#8220;, die im Universit&#228;tsklinikum John Hopkins in Baltimore erstmals verwendet wurde, ist mittlerweile vielfach verwendet und in unterschiedlichen Krankenh&#228;usern oder Regionen in modifizierter Form in den klinischen Alltag integriert worden. Die gemeinsame Festlegung von Tageszielen f&#252;r den Patienten im Team verbessert nachweislich die Kommunikation des Behandlungsteams, macht die Behandlungsziele transparenter und erh&#246;ht die Patientensicherheit mit einem positiven Effekt auf das Patienten-Outcome. </Pgraph><Pgraph>Die Etablierung des neuen QI I auf den deutschen Intensivstationen wird zu tiefgreifenden Ver&#228;nderungen in den Tagesabl&#228;ufen f&#252;hren. Die Standarddokumentationen, ob papiergest&#252;tzt oder in elektronischer Form, werden nachhaltig ver&#228;ndert. Die Transparenz &#252;ber Festlegungen wird steigen. Damit verbunden ist die Nachpr&#252;fbarkeit von erreichten Zielen. Eine solche nachhaltige Ver&#228;nderung des Tagesablaufes von Intensivstationen erfordert die Aufmerksamkeit aller Beteiligten. Die Autoren empfehlen den Verantwortlichen der Intensivstationen diese Ver&#228;nderungen in Form von Projekten umzusetzen. Den Anbietern von Dokumentationsprodukten f&#252;r die Intensivmedizin wird nahe gelegt, L&#246;sungen anzubieten, die das Prozessorientierte Arbeiten mit Tageszielen erleichtert. </Pgraph><SubHeadline>QI II &#8211; Monitoring von Sedierung, Analgesie und Delir</SubHeadline><Pgraph>Der QI II wurde unver&#228;ndert &#252;bernommen. Die Evidenzlage hat sich zum diesem Thema nicht ver&#228;ndert. Die S3-Leitlinie ist weiterhin g&#252;ltig <TextLink reference="8"></TextLink>. In noch nicht publizierten Auswertungen aus den intensivmedizinischen Peer Reviews lie&#223; sich feststellen, dass bei der Umsetzung der Leitlinie noch erhebliches Verbesserungspotential besteht. </Pgraph><SubHeadline>QI III &#8211; Lungenprotektive Beatmung</SubHeadline><Pgraph>Gleiches wie f&#252;r den QI II gilt auch f&#252;r den QI III. Die Evidenzlage f&#252;r die lungenprotektive Beatmung ist weiterhin hoch und die Umsetzung im klinischen Alltag leider immer noch niedrig ausgepr&#228;gt. Die Diskrepanz von theoretischem Wissen der Beteiligten und der Realisierung am intensivmedizinischen Beatmungsbett ist gut publiziert worden <TextLink reference="9"></TextLink>.</Pgraph><SubHeadline>QI IV &#8211; Weaning und Ma&#223;nahmen zur Vermeidung von ventilatorassoziierten Pneumonien </SubHeadline><Pgraph>Die umfangreichste  Modifikation der neuen QIs hat im Indikator IV stattgefunden. Der alte QI I (Oberk&#246;rperhochlagerung) und der alte QI IV (Weaning) haben das gleiche Qualit&#228;tsziel verfolgt: die Reduktion der Inzidenz von ventilatorassoziierten Pneumonien (VAP). Die VAP ist ein wichtiges Intensivmedizinisches Krankheitsbild. In den USA ist die Vermeidung der VAP zu einem zentralen Qualit&#228;tsindikator geworden. Die Verg&#252;tung der durch VAP entstehenden Kosten einer Intensivstation wird hierbei u.a. in Frage gestellt.</Pgraph><Pgraph>Der positive Effekt des Weanings auf die VAP-Vermeidung liegt ma&#223;geblich im Faktor Zeit begr&#252;ndet. Je schneller ein Patient von der Beatmung entw&#246;hnt werden kann, desto geringer ist das Risiko einer ventilatorassoziierten Pneumonie. Das Weaning per se ist jedoch ein sehr komplexer Prozess und ist inhaltlich sehr stark verkn&#252;pft mit dem Sedierungskonzept einer Intensivstation. Die Vermeidung der Atrophie der Atemmuskulatur ist hierbei ein zentraler pathophysiologischer Faktor. Die leitlinienkonforme Analgosedierung ist Voraussetzung f&#252;r erfolgreiches Weaning. Der Erfolg ist an sehr gut auf einander abgestimmte Standards gekoppelt. </Pgraph><Pgraph>Der positive Effekt der Oberk&#246;rperhochlagerung auf die VAP-Vermeidung kann nach heutigem Wissen nicht kommentarlos best&#228;tigt werden. Die Studienlage ist d&#252;nn und die Umsetzung der Oberk&#246;rperhochlagerung ist im klinischen Alltag aus zwei Gr&#252;nden nicht &#252;berpr&#252;fbar: </Pgraph><Pgraph><OrderedList><ListItem level="1" levelPosition="1" numString="1.">die Gradzahl von &#62;&#47;&#61; 30&#176; wird nur selten umgesetzt</ListItem><ListItem level="1" levelPosition="2" numString="2.">es ist nicht klar &#252;ber welche Zeitr&#228;umer die Lagerung umgesetzt wird und welche anderen Ma&#223;nahmen (z.B. Dekubitus-Vermeidung) dadurch behindert werden.</ListItem></OrderedList></Pgraph><Pgraph>Die mangelhafte Praktikabilit&#228;t ist als Ergebnis in vielen Peer Reviews belegt worden. Der Effekt der Oberk&#246;rperhochlagerung auf die VAP Vermeidung liegt in der physikalischen Verminderung von Reflux&#47;Regurgitation aus dem oberen GI-Trakt, d.h. die Verminderung der Aspirationsrate ist die physiologische Endstrecke der Oberk&#246;rperhochlagerung. Mittlerweile konnte gezeigt werden, dass auch das Gegenteil von Oberk&#246;rperhochlagerung, n&#228;mlich die Kopftieflagerung ebenfalls zur Reduktion von Aspiration beitr&#228;gt. Wenn es jedoch haupts&#228;chlich um die Vermeidung der Aspiration von pathogenen Erregern geht, gibt es viele Publikationen aus unterschiedlichen L&#228;ndern, die Ma&#223;nahmen zur Vermeidung von VAP (VAP Bundle) als effektiv beschreiben. Betrachtet man nur die Outcome-Ergebnisse bleiben einige Ma&#223;nahmen als VAP Bundle stehen, die Ihren positiven Effekt belegen k&#246;nnen (Lagerungsprotokoll, H&#228;ndedesinfektion bei Ma&#223;nahmen an den Atemwegen, Mundpflege und orale Dekontamination, Vermeidung oraler Aspiration z.B. durch Cuffdruckmessungen, subglottische Sekretabsaugung. Lagerung ist hierbei als Ma&#223;nahme zu verstehen, die das ausschlie&#223;liche Flachlagern vermeidet und tr&#228;gt damit zur Verminderung der VAP Inzidenz bei. Die anderen aufgef&#252;hrten Ma&#223;nahmen sind exemplarisch zu verstehen, weil f&#252;r jede Ma&#223;nahme jeweils ein outcomerelevanter Effekt gezeigt werden konnte</Pgraph><Pgraph>Die Komplexit&#228;t der VAP Vermeidung haben die Autoren versucht zu ordnen, indem der Qualit&#228;tsindikator auf zwei S&#228;ulen beruht, die beide f&#252;r sich betrachtet, nachpr&#252;fbare Prozesse im klinischen Alltag darstellen.  </Pgraph><Pgraph><OrderedList><ListItem level="1" levelPosition="1" numString="1.">Weaning: nachpr&#252;fbar in der Patientenakte</ListItem><ListItem level="1" levelPosition="2" numString="2.">VAP-Bundle: Nachpr&#252;fbar in der Krankenakte, inklusive Pflegedokumentation</ListItem></OrderedList></Pgraph><SubHeadline>QI V &#8211; Fr&#252;hzeitige und ad&#228;quate Antibiotikatherapie</SubHeadline><Pgraph>Die Inhalte dieses Indikators wurden nicht ver&#228;ndert, da sich die Evidenzlage hierzu nicht ver&#228;ndert hat. Es hat sich in Erfahrung der intensivmedizinischen Peer Reviews gezeigt, dass sich die Anwendung von Sepsis Bundles im Alltag als Herausforderung pr&#228;sentiert. Das fr&#252;hzeitige Erkennen von SIRS&#47;Infektions-Zeichen beim Patienten und die ad&#228;quate Therapie mit Antiinfektiva stellen daher hohe  Anspr&#252;che an die Organisation der Intensivstation. Die Verwendung von &#34;Antibiotic stewardship&#34; Programmen wird hierbei empfohlen <TextLink reference="10"></TextLink>. F&#252;r die ad&#228;quate anitiinfektive Therapie ist ferner die Verwendung von Resistenzdaten von gr&#246;&#223;ter Bedeutung. Die Teilnahme an nationalen Surveillance-Programmen (KISS) ist dringend zu fordern und ist im intensivmedizinischen Alltag leider noch nicht in der Breite etabliert <TextLink reference="11"></TextLink>.</Pgraph><SubHeadline>QI VI &#8211; Therapeutische Hypothermie nach Herzstillstand</SubHeadline><Pgraph>Dieser Indikator ist nicht ver&#228;ndert worden. Die aktuelle europ&#228;ische Leitlinie wurde diesbez&#252;glich zuletzt erg&#228;nzt <TextLink reference="12"></TextLink>. Es scheint nicht zuletzt durch breit angelegte Kampagnen ein Bewusstsein f&#252;r die Notwendigkeit von neuroprotektiven Ma&#223;nahmen zu existieren. Die Autoren halten es f&#252;r sinnvoll, die Umsetzung des QI VI in den Krankenh&#228;usern gesondert zu evaluieren, da das Ereignis Reanimation an Stichtagen, etwa bei einem Peer Review naturgem&#228;&#223; nur selten nachpr&#252;fbar ist. </Pgraph><SubHeadline>QI VII &#8211; Fr&#252;he enterale Ern&#228;hrung</SubHeadline><Pgraph>Dieser Indikator wurde nicht ver&#228;ndert. In den vergangenen Jahren sind zahlreiche Publikationen zum Thema Ern&#228;hrung von Intensivpatienten erschienen. Hierbei hat sich die Evidenz f&#252;r die parenterale Ern&#228;hrung ver&#228;ndert. Die fr&#252;he enterale Ern&#228;hrung bleibt nach wie vor ein anzustrebendes Ziel. Insgesamt ist neben der Forderung die Ern&#228;hrung auf &#8222;nat&#252;rlichem&#8220; Wege anzubieten die ad&#228;quate N&#228;hrstoffzusammensetzung und das Energieangebot f&#252;r den Patienten zu beachten.</Pgraph><SubHeadline>QI VIII &#8211; Dokumentation von strukturierten Angeh&#246;rigengespr&#228;chen</SubHeadline><Pgraph>Dieser Indikator wurde modifiziert. In Peer Reviews wurde beobachtet, dass die Dokumentation von Angeh&#246;rigengespr&#228;chen auf Intensivstationen nicht befriedigend umgesetzt ist. Es fehlt die Zielorientierung, d.h. die Inhalte der Dokumentation lassen h&#228;ufig nicht erkennen, welche Themen mit den Angeh&#246;rigen besprochen wurden und welche gemeinsamen Festlegungen im (mutma&#223;lichen) Interesse des Patienten getroffen wurden. Es erschien daher notwendig, den Indikator zu differenzieren. Es wird deutlich, dass sich die Dokumentationsvorlagen auf den Intensivstationen den Erfordernissen dieses Indikators anpassen sollten.</Pgraph><SubHeadline>QI IX &#8211; H&#228;ndedesinfektionsmittelverbrauch</SubHeadline><Pgraph>Dieser Indikator wurde unver&#228;ndert &#252;bernommen. Die unzureichende H&#228;ndedesinfektion im Alltag macht es notwendig, diesen Indikator weiterhin zu fokussieren. In den Peer Reviews wurde deutlich, dass eine Unsicherheit bei der Anwendung des Indikators besteht. Es muss hierbei wiederholt betont werden, dass die Erfassung der verbrauchten Menge von H&#228;ndedesinfektionsmittel einer Intensivstation nicht ausreicht, um den Indikator zu erf&#252;llen. Es geht konkret um den Bezug der Desinfektionsmittelmenge zu den Belegungstagen einer Intensivstation&#33; Die im Indikator angegebene Bezugsgr&#246;&#223;e soll erf&#252;llt werden, um der Ma&#223;gabe eines ad&#228;quaten Desinfektionsmittelverbrauchs gerecht zu werden.</Pgraph><SubHeadline>QI X &#8211; Leitung der Intensivstation durch einen Facharzt mit Zusatzbezeichnung Intensivmedizin, der keine anderen klinischen Aufgaben hat, Pr&#228;senz eines Facharztes mit Zusatzbezeichnung Intensivmedizin in der Kernarbeitszeit und Gew&#228;hrleistung der Pr&#228;senz von intensivmedizinisch erfahrenem &#228;rztlichem und pflegerischem Personal &#252;ber 24 h</SubHeadline><Pgraph>Dieser Indikator wurde modifiziert. Die Evidenzlage zu den Inhalten dieses Indikators ist sehr hoch zu bewerten. Zur ad&#228;quaten Versorgung von intensivmedizinischen Patienten ist die 24-st&#252;ndige Pr&#228;senz eines erfahrenen und qualifizierten pflegerischen und &#228;rztlichen Teams notwendig. Die aktuelle Studienlage zeigt ferner, dass in der Kernarbeitszeit, d.h. in der Zeit, in der wichtige Entscheidungen im interdisziplin&#228;ren Kontext zu treffen sind und die Verf&#252;gbarkeit aller Entscheidungstr&#228;ger gegeben ist, die Pr&#228;senz eines Facharztes mit Zusatzbezeichnung (&#61; erfahrener und qualifizierter Intensivmediziner) notwendig ist <TextLink reference="13"></TextLink>. Dieser pr&#228;sente Intensivmediziner kann aber muss nicht identisch sein mit dem Leiter der Intensivstation. Der Leiter der Intensivstation darf keine anderen klinischen Aufgaben auf sich vereinen als die fachliche Leitung der Intensivstation. Der Leiter der Station kann ein Chefarzt oder ein leitender Oberarzt sein. Dies entspricht den Anforderungen der DIVI. Dieser Indikator legt inhaltlich ferner fest, dass die pflegerische Besetzung der Station bei beatmeten Patienten (hierzu m&#252;ssen auch non-invasiv beatmete Patienten gerechnet werden) ein Verh&#228;ltnis von einer Pflegekraft auf zwei Patienten nicht unterschreiten darf.</Pgraph></TextBlock>
    <TextBlock language="en" linked="yes" name="Notes">
      <MainHeadline>Notes</MainHeadline><SubHeadline>Authorship</SubHeadline><Pgraph>Jan-Peter Braun and Oliver Kumpf contributed equally to this article.</Pgraph><SubHeadline>Competing interests</SubHeadline><Pgraph>The authors declare that they have no competing interests.</Pgraph></TextBlock>
    <TextBlock language="de" linked="yes" name="Anmerkungen">
      <MainHeadline>Anmerkungen</MainHeadline><SubHeadline>Autorenschaft</SubHeadline><Pgraph>Jan-Peter Braun und Oliver Kumpf haben zu diesem Artikel in gleichem Ma&#223;e beigetragen.</Pgraph><SubHeadline>Interessenkonflikte</SubHeadline><Pgraph>Die Autoren erkl&#228;ren, dass sie keine Interessenkonflikte in Zusammenhang mit diesem Artikel haben.</Pgraph></TextBlock>
    <References linked="yes">
      <Reference refNo="1">
        <RefAuthor>Braun JP</RefAuthor>
        <RefAuthor>Mende H</RefAuthor>
        <RefAuthor>Bause H</RefAuthor>
        <RefAuthor>Bloos F</RefAuthor>
        <RefAuthor>Geldner G</RefAuthor>
        <RefAuthor>Kastrup M</RefAuthor>
        <RefAuthor>Kuhlen R</RefAuthor>
        <RefAuthor>Markewitz A</RefAuthor>
        <RefAuthor>Martin J</RefAuthor>
        <RefAuthor>Quintel M</RefAuthor>
        <RefAuthor>Steinmeier-Bauer K</RefAuthor>
        <RefAuthor>Waydhas C</RefAuthor>
        <RefAuthor>Spies C</RefAuthor>
        <RefAuthor> NeQuI (quality network in intensive care medicine)</RefAuthor>
        <RefTitle>Quality indicators in intensive care medicine: why&#63; Use or burden for the intensivist</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Ger Med Sci</RefJournal>
        <RefPage>Doc22</RefPage>
        <RefTotal>Braun JP, Mende H, Bause H, Bloos F, Geldner G, Kastrup M, Kuhlen R, Markewitz A, Martin J, Quintel M, Steinmeier-Bauer K, Waydhas C, Spies C; NeQuI (quality network in intensive care medicine). Quality indicators in intensive care medicine: why&#63; Use or burden for the intensivist. Ger Med Sci. 2010 Sep 28;8:Doc22. DOI: 10.3205&#47;000111</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.3205&#47;000111</RefLink>
      </Reference>
      <Reference refNo="2">
        <RefAuthor>Najjar-Pellet J</RefAuthor>
        <RefAuthor>Jonquet O</RefAuthor>
        <RefAuthor>Jambou P</RefAuthor>
        <RefAuthor>Fabry J</RefAuthor>
        <RefTitle>Quality assessment in intensive care units: proposal for a scoring system in terms of structure and process</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>278-85</RefPage>
        <RefTotal>Najjar-Pellet J, Jonquet O, Jambou P, Fabry J. Quality assessment in intensive care units: proposal for a scoring system in terms of structure and process. Intensive Care Med. 2008 Feb;34(2):278-85. DOI: 10.1007&#47;s00134-007-0883-9</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s00134-007-0883-9</RefLink>
      </Reference>
      <Reference refNo="3">
        <RefAuthor>Rhodes A</RefAuthor>
        <RefAuthor>Moreno RP</RefAuthor>
        <RefAuthor>Azoulay E</RefAuthor>
        <RefAuthor>Capuzzo M</RefAuthor>
        <RefAuthor>Chiche JD</RefAuthor>
        <RefAuthor>Eddleston J</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM)</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>598-605</RefPage>
        <RefTotal>Rhodes A, Moreno RP, Azoulay E, Capuzzo M, Chiche JD, Eddleston J, et al.  Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM). Intensive Care Med. 2012 Apr;38(4):598-605. DOI: 10.1007&#47;s00134-011-2462-3</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s00134-011-2462-3</RefLink>
      </Reference>
      <Reference refNo="4">
        <RefAuthor>Flaatten H</RefAuthor>
        <RefTitle>The present use of quality indicators in the intensive care unit</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>Acta Anaesthesiol Scand</RefJournal>
        <RefPage>1078-83</RefPage>
        <RefTotal>Flaatten H. The present use of quality indicators in the intensive care unit. Acta Anaesthesiol Scand. 2012 Oct;56(9):1078-83. DOI: 10.1111&#47;j.1399-6576.2012.02656.x</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1111&#47;j.1399-6576.2012.02656.x</RefLink>
      </Reference>
      <Reference refNo="5">
        <RefAuthor>Braun JP</RefAuthor>
        <RefAuthor>Bause H</RefAuthor>
        <RefTitle>Peer Reviews in der Intensivmedizin</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>Z Evid Fortbild Qual Gesundhwes</RefJournal>
        <RefPage>566-70</RefPage>
        <RefTotal>Braun JP, Bause H. Peer Reviews in der Intensivmedizin &#91;Peer review in ICU&#93;. Z Evid Fortbild Qual Gesundhwes. 2012;106(8):566-70. DOI: 10.1016&#47;j.zefq.2012.09.001</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.zefq.2012.09.001</RefLink>
      </Reference>
      <Reference refNo="6">
        <RefAuthor>Braun JP</RefAuthor>
        <RefAuthor>Bause H</RefAuthor>
        <RefAuthor>Bloos F</RefAuthor>
        <RefAuthor>Geldner G</RefAuthor>
        <RefAuthor>Kastrup M</RefAuthor>
        <RefAuthor>Kuhlen R</RefAuthor>
        <RefAuthor>Markewitz A</RefAuthor>
        <RefAuthor>Martin J</RefAuthor>
        <RefAuthor>Mende H</RefAuthor>
        <RefAuthor>Quintel M</RefAuthor>
        <RefAuthor>Steinmeier-Bauer K</RefAuthor>
        <RefAuthor>Waydhas C</RefAuthor>
        <RefAuthor>Spies C</RefAuthor>
        <RefAuthor> NeQuI (quality network in intensive care medicine)</RefAuthor>
        <RefTitle>Peer reviewing critical care: a pragmatic approach to quality management</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Ger Med Sci</RefJournal>
        <RefPage>Doc23</RefPage>
        <RefTotal>Braun JP, Bause H, Bloos F, Geldner G, Kastrup M, Kuhlen R, Markewitz A, Martin J, Mende H, Quintel M, Steinmeier-Bauer K, Waydhas C, Spies C; NeQuI (quality network in intensive care medicine). Peer reviewing critical care: a pragmatic approach to quality management. Ger Med Sci. 2010 Oct 8;8:Doc23. DOI: 10.3205&#47;000112</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.3205&#47;000112</RefLink>
      </Reference>
      <Reference refNo="7">
        <RefAuthor>Pronovost P</RefAuthor>
        <RefAuthor>Berenholtz S</RefAuthor>
        <RefAuthor>Dorman T</RefAuthor>
        <RefAuthor>Lipsett PA</RefAuthor>
        <RefAuthor>Simmonds T</RefAuthor>
        <RefAuthor>Haraden C</RefAuthor>
        <RefTitle>Improving communication in the ICU using daily goals</RefTitle>
        <RefYear>2003</RefYear>
        <RefJournal>J Crit Care</RefJournal>
        <RefPage>71-5</RefPage>
        <RefTotal>Pronovost P, Berenholtz S, Dorman T, Lipsett PA, Simmonds T, Haraden C. Improving communication in the ICU using daily goals. J Crit Care. 2003 Jun;18(2):71-5. DOI: 10.1053&#47;jcrc.2003.50008</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1053&#47;jcrc.2003.50008</RefLink>
      </Reference>
      <Reference refNo="8">
        <RefAuthor>Martin J</RefAuthor>
        <RefAuthor>Heymann A</RefAuthor>
        <RefAuthor>B&#228;sell K</RefAuthor>
        <RefAuthor>Baron R</RefAuthor>
        <RefAuthor>Biniek R</RefAuthor>
        <RefAuthor>B&#252;rkle H</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care &#8211; short version</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Ger Med Sci</RefJournal>
        <RefPage>Doc02</RefPage>
        <RefTotal>Martin J, Heymann A, B&#228;sell K, Baron R, Biniek R, B&#252;rkle H, et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care &#8211; short version. Ger Med Sci. 2010 Feb 2;8:Doc02. DOI: 10.3205&#47;000091</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.3205&#47;000091</RefLink>
      </Reference>
      <Reference refNo="9">
        <RefAuthor>Brunkhorst FM</RefAuthor>
        <RefAuthor>Engel C</RefAuthor>
        <RefAuthor>Ragaller M</RefAuthor>
        <RefAuthor>Welte T</RefAuthor>
        <RefAuthor>Rossaint R</RefAuthor>
        <RefAuthor>Gerlach H</RefAuthor>
        <RefAuthor>Mayer K</RefAuthor>
        <RefAuthor>John S</RefAuthor>
        <RefAuthor>Stuber F</RefAuthor>
        <RefAuthor>Weiler N</RefAuthor>
        <RefAuthor>Oppert M</RefAuthor>
        <RefAuthor>Moerer O</RefAuthor>
        <RefAuthor>Bogatsch H</RefAuthor>
        <RefAuthor>Reinhart K</RefAuthor>
        <RefAuthor>Loeffler M</RefAuthor>
        <RefAuthor>Hartog C</RefAuthor>
        <RefAuthor> German Sepsis Competence Network (SepNet)</RefAuthor>
        <RefTitle>Practice and perception &#8211; a nationwide survey of therapy habits in sepsis</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>2719-25</RefPage>
        <RefTotal>Brunkhorst FM, Engel C, Ragaller M, Welte T, Rossaint R, Gerlach H, Mayer K, John S, Stuber F, Weiler N, Oppert M, Moerer O, Bogatsch H, Reinhart K, Loeffler M, Hartog C; German Sepsis Competence Network (SepNet). Practice and perception &#8211; a nationwide survey of therapy habits in sepsis. Crit Care Med. 2008 Oct;36(10):2719-25. DOI: 10.1097&#47;CCM.0b013e318186b6f3</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;CCM.0b013e318186b6f3</RefLink>
      </Reference>
      <Reference refNo="10">
        <RefAuthor>Doron S</RefAuthor>
        <RefAuthor>Davidson LE</RefAuthor>
        <RefTitle>Antimicrobial stewardship</RefTitle>
        <RefYear>2011</RefYear>
        <RefJournal>Mayo Clin Proc</RefJournal>
        <RefPage>1113-23</RefPage>
        <RefTotal>Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011 Nov;86(11):1113-23. DOI: 10.4065&#47;mcp.2011.0358</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.4065&#47;mcp.2011.0358</RefLink>
      </Reference>
      <Reference refNo="11">
        <RefAuthor>Zuschneid I</RefAuthor>
        <RefAuthor>R&#252;cker G</RefAuthor>
        <RefAuthor>Schoop R</RefAuthor>
        <RefAuthor>Beyersmann J</RefAuthor>
        <RefAuthor>Schumacher M</RefAuthor>
        <RefAuthor>Geffers C</RefAuthor>
        <RefAuthor>R&#252;den H</RefAuthor>
        <RefAuthor>Gastmeier P</RefAuthor>
        <RefTitle>Representativeness of the surveillance data in the intensive care unit component of the German nosocomial infections surveillance system</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Infect Control Hosp Epidemiol</RefJournal>
        <RefPage>934-8</RefPage>
        <RefTotal>Zuschneid I, R&#252;cker G, Schoop R, Beyersmann J, Schumacher M, Geffers C, R&#252;den H, Gastmeier P. Representativeness of the surveillance data in the intensive care unit component of the German nosocomial infections surveillance system. Infect Control Hosp Epidemiol. 2010 Sep;31(9):934-8. DOI: 10.1086&#47;655462</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1086&#47;655462</RefLink>
      </Reference>
      <Reference refNo="12">
        <RefAuthor>Deakin CD</RefAuthor>
        <RefAuthor>Nolan JP</RefAuthor>
        <RefAuthor>Soar J</RefAuthor>
        <RefAuthor>Sunde K</RefAuthor>
        <RefAuthor>Koster RW</RefAuthor>
        <RefAuthor>Smith GB</RefAuthor>
        <RefAuthor>Perkins GD</RefAuthor>
        <RefTitle>European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Resuscitation</RefJournal>
        <RefPage>1305-52</RefPage>
        <RefTotal>Deakin CD, Nolan JP, Soar J, Sunde K, Koster RW, Smith GB, Perkins GD. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation. 2010 Oct;81(10):1305-52. DOI: 10.1016&#47;j.resuscitation.2010.08.017</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.resuscitation.2010.08.017</RefLink>
      </Reference>
      <Reference refNo="13">
        <RefAuthor>Wallace DJ</RefAuthor>
        <RefAuthor>Angus DC</RefAuthor>
        <RefAuthor>Barnato AE</RefAuthor>
        <RefAuthor>Kramer AA</RefAuthor>
        <RefAuthor>Kahn JM</RefAuthor>
        <RefTitle>Nighttime intensivist staffing and mortality among critically ill patients</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>2093-101</RefPage>
        <RefTotal>Wallace DJ, Angus DC, Barnato AE, Kramer AA, Kahn JM. Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med. 2012 May 31;366(22):2093-101. DOI: 10.1056&#47;NEJMsa1201918</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJMsa1201918</RefLink>
      </Reference>
      <Reference refNo="14">
        <RefAuthor>Khorfan F</RefAuthor>
        <RefTitle>Daily goals checklist &#8211; a goal-directed method to eliminate nosocomial infection in the intensive care unit</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>J Healthc Qual</RefJournal>
        <RefPage>13-7</RefPage>
        <RefTotal>Khorfan F. Daily goals checklist &#8211; a goal-directed method to eliminate nosocomial infection in the intensive care unit. J Healthc Qual. 2008 Nov-Dec;30(6):13-7. DOI: 10.1111&#47;j.1945-1474.2008.tb01165.x</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1111&#47;j.1945-1474.2008.tb01165.x</RefLink>
      </Reference>
      <Reference refNo="15">
        <RefAuthor>Newkirk M</RefAuthor>
        <RefAuthor>Pamplin JC</RefAuthor>
        <RefAuthor>Kuwamoto R</RefAuthor>
        <RefAuthor>Allen DA</RefAuthor>
        <RefAuthor>Chung KK</RefAuthor>
        <RefTitle>Checklists change communication about key elements of patient care</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>J Trauma Acute Care Surg</RefJournal>
        <RefPage>S75-82</RefPage>
        <RefTotal>Newkirk M, Pamplin JC, Kuwamoto R, Allen DA, Chung KK. Checklists change communication about key elements of patient care. J Trauma Acute Care Surg. 2012  Aug;73(2 Suppl 1):S75-82. DOI: 10.1097&#47;TA.0b013e3182606239</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;TA.0b013e3182606239</RefLink>
      </Reference>
      <Reference refNo="16">
        <RefAuthor>Gusmao-Flores D</RefAuthor>
        <RefAuthor>Figueira Salluh JI</RefAuthor>
        <RefAuthor>Chalhub RA</RefAuthor>
        <RefAuthor>Quarantini LC</RefAuthor>
        <RefTitle>The confusion  assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies</RefTitle>
        <RefYear>2012</RefYear>
        <RefJournal>Crit Care</RefJournal>
        <RefPage>R115</RefPage>
        <RefTotal>Gusmao-Flores D, Figueira Salluh JI, Chalhub RA, Quarantini LC. The confusion  assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care. 2012 Jul 3;16(4):R115. DOI: 10.1186&#47;cc11407</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1186&#47;cc11407</RefLink>
      </Reference>
      <Reference refNo="17">
        <RefAuthor>Weiss CH</RefAuthor>
        <RefAuthor>Moazed F</RefAuthor>
        <RefAuthor>McEvoy CA</RefAuthor>
        <RefAuthor>Singer BD</RefAuthor>
        <RefAuthor>Szleifer I</RefAuthor>
        <RefAuthor>Amaral LA</RefAuthor>
        <RefAuthor>Kwasny M</RefAuthor>
        <RefAuthor>Watts CM</RefAuthor>
        <RefAuthor>Persell SD</RefAuthor>
        <RefAuthor>Baker DW</RefAuthor>
        <RefAuthor>Sznajder JI</RefAuthor>
        <RefAuthor>Wunderink RG</RefAuthor>
        <RefTitle>Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site study</RefTitle>
        <RefYear>2011</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>680-6</RefPage>
        <RefTotal>Weiss CH, Moazed F, McEvoy CA, Singer BD, Szleifer I, Amaral LA, Kwasny M, Watts CM, Persell SD, Baker DW, Sznajder JI, Wunderink RG. Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site study. Am J Respir Crit Care Med. 2011 Sep 15;184(6):680-6. DOI: 10.1164&#47;rccm.201101-0037OC</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.201101-0037OC</RefLink>
      </Reference>
      <Reference refNo="18">
        <RefAuthor>Jeffries HE</RefAuthor>
        <RefAuthor>Mason W</RefAuthor>
        <RefAuthor>Brewer M</RefAuthor>
        <RefAuthor>Oakes KL</RefAuthor>
        <RefAuthor>Mu-oz EI</RefAuthor>
        <RefAuthor>Gornick W</RefAuthor>
        <RefAuthor>Flowers LD</RefAuthor>
        <RefAuthor>Mullen JE</RefAuthor>
        <RefAuthor>Gilliam CH</RefAuthor>
        <RefAuthor>Fustar S</RefAuthor>
        <RefAuthor>Thurm CW</RefAuthor>
        <RefAuthor>Logsdon T</RefAuthor>
        <RefAuthor>Jarvis WR</RefAuthor>
        <RefTitle>Prevention of central venous catheter-associated bloodstream infections in pediatric intensive care units: a performance improvement collaborative</RefTitle>
        <RefYear>2009</RefYear>
        <RefJournal>Infect Control Hosp Epidemiol</RefJournal>
        <RefPage>645-51</RefPage>
        <RefTotal>Jeffries HE, Mason W, Brewer M, Oakes KL, Mu-oz EI, Gornick W, Flowers LD, Mullen JE, Gilliam CH, Fustar S, Thurm CW, Logsdon T, Jarvis WR. Prevention of central venous catheter-associated bloodstream infections in pediatric intensive care units: a performance improvement collaborative. Infect Control Hosp Epidemiol. 2009 Jul;30(7):645-51. DOI: 10.1086&#47;598341</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1086&#47;598341</RefLink>
      </Reference>
      <Reference refNo="19">
        <RefAuthor>Tallgren M</RefAuthor>
        <RefAuthor>Pettil&#228; V</RefAuthor>
        <RefAuthor>Hynninen M</RefAuthor>
        <RefTitle>Quality assessment of sedation in intensive care</RefTitle>
        <RefYear>2006</RefYear>
        <RefJournal>Acta Anaesthesiol Scand</RefJournal>
        <RefPage>942-6</RefPage>
        <RefTotal>Tallgren M, Pettil&#228; V, Hynninen M. Quality assessment of sedation in intensive care. Acta Anaesthesiol Scand. 2006 Sep;50(8):942-6. DOI: 10.1111&#47;j.1399-6576.2006.01094.x</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1111&#47;j.1399-6576.2006.01094.x</RefLink>
      </Reference>
      <Reference refNo="20">
        <RefAuthor>The Acute Respiratory Distress Syndrome Network</RefAuthor>
        <RefTitle>Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network</RefTitle>
        <RefYear>2000</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>1301-8</RefPage>
        <RefTotal>The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000 May 4;342(18):1301-8. DOI: 10.1056&#47;NEJM200005043421801</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJM200005043421801</RefLink>
      </Reference>
      <Reference refNo="21">
        <RefAuthor>Brower RG</RefAuthor>
        <RefAuthor>Lanken PN</RefAuthor>
        <RefAuthor>MacIntyre N</RefAuthor>
        <RefAuthor>Matthay MA</RefAuthor>
        <RefAuthor>Morris A</RefAuthor>
        <RefAuthor>Ancukiewicz M</RefAuthor>
        <RefAuthor>Schoenfeld D</RefAuthor>
        <RefAuthor>Thompson BT</RefAuthor>
        <RefAuthor> National Heart</RefAuthor>
        <RefAuthor>Lung</RefAuthor>
        <RefAuthor>and Blood Institute ARDS Clinical Trials Network</RefAuthor>
        <RefTitle>Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome</RefTitle>
        <RefYear>2004</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>327-36</RefPage>
        <RefTotal>Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22;351(4):327-36. DOI: 10.1056&#47;NEJMoa032193</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJMoa032193</RefLink>
      </Reference>
      <Reference refNo="22">
        <RefAuthor>American Thoracic Society</RefAuthor>
        <RefAuthor> Infectious Diseases Society of America</RefAuthor>
        <RefTitle>Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia</RefTitle>
        <RefYear>2005</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>388-416</RefPage>
        <RefTotal>American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416. DOI: 10.1164&#47;rccm.200405-644ST</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.200405-644ST</RefLink>
      </Reference>
      <Reference refNo="23">
        <RefAuthor>Mercat A</RefAuthor>
        <RefAuthor>Richard JC</RefAuthor>
        <RefAuthor>Vielle B</RefAuthor>
        <RefAuthor>Jaber S</RefAuthor>
        <RefAuthor>Osman D</RefAuthor>
        <RefAuthor>Diehl JL</RefAuthor>
        <RefAuthor>Lefrant JY</RefAuthor>
        <RefAuthor>Prat G</RefAuthor>
        <RefAuthor>Richecoeur J</RefAuthor>
        <RefAuthor>Nieszkowska A</RefAuthor>
        <RefAuthor>Gervais C</RefAuthor>
        <RefAuthor>Baudot J</RefAuthor>
        <RefAuthor>Bouadma L</RefAuthor>
        <RefAuthor>Brochard L</RefAuthor>
        <RefAuthor> Expiratory Pressure (Express) Study Group</RefAuthor>
        <RefTitle>Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>JAMA</RefJournal>
        <RefPage>646-55</RefPage>
        <RefTotal>Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008 Feb 13;299(6):646-55. DOI: 10.1001&#47;jama.299.6.646</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1001&#47;jama.299.6.646</RefLink>
      </Reference>
      <Reference refNo="24">
        <RefAuthor>Gastmeier P</RefAuthor>
        <RefAuthor>Geffers C</RefAuthor>
        <RefTitle>Prevention of ventilator-associated pneumonia: analysis of studies published since 2004</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>J Hosp Infect</RefJournal>
        <RefPage>1-8</RefPage>
        <RefTotal>Gastmeier P, Geffers C. Prevention of ventilator-associated pneumonia: analysis of studies published since 2004. J Hosp Infect. 2007 Sep;67(1):1-8. DOI: 10.1016&#47;j.jhin.2007.06.011</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.jhin.2007.06.011</RefLink>
      </Reference>
      <Reference refNo="25">
        <RefAuthor>Alvarez-Lerma F</RefAuthor>
        <RefAuthor>Palomar M</RefAuthor>
        <RefAuthor>Olaechea P</RefAuthor>
        <RefAuthor>Otal JJ</RefAuthor>
        <RefAuthor>Insausti J</RefAuthor>
        <RefAuthor>Cerd&#225; E</RefAuthor>
        <RefAuthor> Grupo de Estudio de Vigilacia de Infecci&#243;n Nosocomial en UCI</RefAuthor>
        <RefTitle>Estudio Nacional de Vigilancia de Infeccion Nosocomial en Unidades de Cuidados Intensivos. Informe evolutivo de los anos 2003&#8211;2005</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>Med Intensiva</RefJournal>
        <RefPage>6-17</RefPage>
        <RefTotal>Alvarez-Lerma F, Palomar M, Olaechea P, Otal JJ, Insausti J, Cerd&#225; E; Grupo de Estudio de Vigilacia de Infecci&#243;n Nosocomial en UCI. Estudio Nacional de Vigilancia de Infeccion Nosocomial en Unidades de Cuidados Intensivos. Informe evolutivo de los anos 2003&#8211;2005 &#91;National Study of Control of Nosocomial Infection in Intensive Care Units. Evolutive report of the years 2003-2005&#93;. Med Intensiva. 2007 Jan-Feb;31(1):6-17.</RefTotal>
      </Reference>
      <Reference refNo="26">
        <RefAuthor>Villar J</RefAuthor>
        <RefAuthor>P&#233;rez-M&#233;ndez L</RefAuthor>
        <RefAuthor>L&#243;pez J</RefAuthor>
        <RefAuthor>Belda J</RefAuthor>
        <RefAuthor>Blanco J</RefAuthor>
        <RefAuthor>Saralegui I</RefAuthor>
        <RefAuthor>Su&#225;rez-Sipmann F</RefAuthor>
        <RefAuthor>L&#243;pez J</RefAuthor>
        <RefAuthor>Lubillo S</RefAuthor>
        <RefAuthor>Kacmarek RM</RefAuthor>
        <RefAuthor> HELP Network</RefAuthor>
        <RefTitle>An early PEEP&#47;FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>795-804</RefPage>
        <RefTotal>Villar J, P&#233;rez-M&#233;ndez L, L&#243;pez J, Belda J, Blanco J, Saralegui I, Su&#225;rez-Sipmann F, L&#243;pez J, Lubillo S, Kacmarek RM; HELP Network. An early PEEP&#47;FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007 Oct 15;176(8):795-804. DOI: 10.1164&#47;rccm.200610-1534OC</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.200610-1534OC</RefLink>
      </Reference>
      <Reference refNo="27">
        <RefAuthor>Lellouche F</RefAuthor>
        <RefAuthor>Mancebo J</RefAuthor>
        <RefAuthor>Jolliet P</RefAuthor>
        <RefAuthor>Roeseler J</RefAuthor>
        <RefAuthor>Schortgen F</RefAuthor>
        <RefAuthor>Dojat M</RefAuthor>
        <RefAuthor>Cabello B</RefAuthor>
        <RefAuthor>Bouadma L</RefAuthor>
        <RefAuthor>Rodriguez P</RefAuthor>
        <RefAuthor>Maggiore S</RefAuthor>
        <RefAuthor>Reynaert M</RefAuthor>
        <RefAuthor>Mersmann S</RefAuthor>
        <RefAuthor>Brochard L</RefAuthor>
        <RefTitle>A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation</RefTitle>
        <RefYear>2006</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>894-900</RefPage>
        <RefTotal>Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, Reynaert M, Mersmann S, Brochard L. A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med. 2006 Oct 15;174(8):894-900. DOI: 10.1164&#47;rccm.200511-1780OC</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.200511-1780OC</RefLink>
      </Reference>
      <Reference refNo="28">
        <RefAuthor>Alexiou VG</RefAuthor>
        <RefAuthor>Ierodiakonou V</RefAuthor>
        <RefAuthor>Dimopoulos G</RefAuthor>
        <RefAuthor>Falagas ME</RefAuthor>
        <RefTitle>Impact of patient position on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials</RefTitle>
        <RefYear>2009</RefYear>
        <RefJournal>J Crit Care</RefJournal>
        <RefPage>515-22</RefPage>
        <RefTotal>Alexiou VG, Ierodiakonou V, Dimopoulos G, Falagas ME. Impact of patient position on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. J Crit Care. 2009 Dec;24(4):515-22. DOI: 10.1016&#47;j.jcrc.2008.09.003</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.jcrc.2008.09.003</RefLink>
      </Reference>
      <Reference refNo="29">
        <RefAuthor>Chan EY</RefAuthor>
        <RefAuthor>Ruest A</RefAuthor>
        <RefAuthor>Meade MO</RefAuthor>
        <RefAuthor>Cook DJ</RefAuthor>
        <RefTitle>Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>BMJ</RefJournal>
        <RefPage>889</RefPage>
        <RefTotal>Chan EY, Ruest A, Meade MO, Cook DJ. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ. 2007 Apr 28;334(7599):889. DOI: 10.1136&#47;bmj.39136.528160.BE</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1136&#47;bmj.39136.528160.BE</RefLink>
      </Reference>
      <Reference refNo="30">
        <RefAuthor>Deja M</RefAuthor>
        <RefAuthor>Trefzer T</RefAuthor>
        <RefAuthor>Geffers C</RefAuthor>
        <RefTitle>Pr&#228;vention der ventilatorassoziierten Pneumonie &#8211; Was ist evidenzbasiert&#63;</RefTitle>
        <RefYear>2011</RefYear>
        <RefJournal>Anasthesiol Intensivmed Notfallmed Schmerzther</RefJournal>
        <RefPage>560-7</RefPage>
        <RefTotal>Deja M, Trefzer T, Geffers C. Pr&#228;vention der ventilatorassoziierten Pneumonie &#8211; Was ist evidenzbasiert&#63; &#91;Prevention of ventilator-associated pneumonia: what&#39;s evidence-based treatment&#63;&#93;. Anasthesiol Intensivmed Notfallmed Schmerzther. 2011 Sep;46(9):560-7. DOI: 10.1055&#47;s-0031-1286606</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1055&#47;s-0031-1286606</RefLink>
      </Reference>
      <Reference refNo="31">
        <RefAuthor>Dellinger RP</RefAuthor>
        <RefAuthor>Levy MM</RefAuthor>
        <RefAuthor>Carlet JM</RefAuthor>
        <RefAuthor>Bion J</RefAuthor>
        <RefAuthor>Parker MM</RefAuthor>
        <RefAuthor>Jaeschke R</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>17-60</RefPage>
        <RefTotal>Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008 Jan;34(1):17-60. DOI: 10.1007&#47;s00134-007-0934-2</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s00134-007-0934-2</RefLink>
      </Reference>
      <Reference refNo="32">
        <RefAuthor>Drakulovic MB</RefAuthor>
        <RefAuthor>Torres A</RefAuthor>
        <RefAuthor>Bauer TT</RefAuthor>
        <RefAuthor>Nicolas JM</RefAuthor>
        <RefAuthor>Nogu&#233; S</RefAuthor>
        <RefAuthor>Ferrer M</RefAuthor>
        <RefTitle>Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial</RefTitle>
        <RefYear>1999</RefYear>
        <RefJournal>Lancet</RefJournal>
        <RefPage>1851-8</RefPage>
        <RefTotal>Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogu&#233; S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet. 1999 Nov 27;354(9193):1851-8. DOI: 10.1016&#47;S0140-6736(98)12251-1 </RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;S0140-6736(98)12251-1</RefLink>
      </Reference>
      <Reference refNo="33">
        <RefAuthor>Dezfulian C</RefAuthor>
        <RefAuthor>Shojania K</RefAuthor>
        <RefAuthor>Collard HR</RefAuthor>
        <RefAuthor>Kim HM</RefAuthor>
        <RefAuthor>Matthay MA</RefAuthor>
        <RefAuthor>Saint S</RefAuthor>
        <RefTitle>Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis</RefTitle>
        <RefYear>2005</RefYear>
        <RefJournal>Am J Med</RefJournal>
        <RefPage>11-8</RefPage>
        <RefTotal>Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005 Jan;118(1):11-8. DOI: 10.1016&#47;j.amjmed.2004.07.051</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.amjmed.2004.07.051</RefLink>
      </Reference>
      <Reference refNo="34">
        <RefAuthor>Dellinger RP</RefAuthor>
        <RefAuthor>Carlet JM</RefAuthor>
        <RefAuthor>Masur H</RefAuthor>
        <RefAuthor>Gerlach H</RefAuthor>
        <RefAuthor>Calandra T</RefAuthor>
        <RefAuthor>Cohen J</RefAuthor>
        <RefAuthor>Gea-Banacloche J</RefAuthor>
        <RefAuthor>Keh D</RefAuthor>
        <RefAuthor>Marshall JC</RefAuthor>
        <RefAuthor>Parker MM</RefAuthor>
        <RefAuthor>Ramsay G</RefAuthor>
        <RefAuthor>Zimmerman JL</RefAuthor>
        <RefAuthor>Vincent JL</RefAuthor>
        <RefAuthor>Levy MM</RefAuthor>
        <RefTitle>Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock</RefTitle>
        <RefYear>2004</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>536-55</RefPage>
        <RefTotal>Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004 Apr;30(4):536-55. DOI: 10.1007&#47;s00134-004-2210-z</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s00134-004-2210-z</RefLink>
      </Reference>
      <Reference refNo="35">
        <RefAuthor>Girard TD</RefAuthor>
        <RefAuthor>Kress JP</RefAuthor>
        <RefAuthor>Fuchs BD</RefAuthor>
        <RefAuthor>Thomason JW</RefAuthor>
        <RefAuthor>Schweickert WD</RefAuthor>
        <RefAuthor>Pun BT</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Lancet</RefJournal>
        <RefPage>126-34</RefPage>
        <RefTotal>Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008 Jan;371(9607):126-34. DOI: 10.1016&#47;S0140-6736(08)60105-1</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;S0140-6736(08)60105-1</RefLink>
      </Reference>
      <Reference refNo="36">
        <RefAuthor>Navalesi P</RefAuthor>
        <RefAuthor>Frigerio P</RefAuthor>
        <RefAuthor>Moretti MP</RefAuthor>
        <RefAuthor>Sommariva M</RefAuthor>
        <RefAuthor>Vesconi S</RefAuthor>
        <RefAuthor>Baiardi P</RefAuthor>
        <RefAuthor>Levati A</RefAuthor>
        <RefTitle>Rate of reintubation in mechanically ventilated neurosurgical and neurologic patients: evaluation of a systematic approach to weaning and extubation</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>2986-92</RefPage>
        <RefTotal>Navalesi P, Frigerio P, Moretti MP, Sommariva M, Vesconi S, Baiardi P, Levati A. Rate of reintubation in mechanically ventilated neurosurgical and neurologic patients: evaluation of a systematic approach to weaning and extubation. Crit Care Med. 2008 Nov;36(11):2986-92. DOI: 10.1097&#47;CCM.0b013e31818b35f2</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;CCM.0b013e31818b35f2</RefLink>
      </Reference>
      <Reference refNo="37">
        <RefAuthor>Rello J</RefAuthor>
        <RefAuthor>Lode H</RefAuthor>
        <RefAuthor>Cornaglia G</RefAuthor>
        <RefAuthor>Masterton R</RefAuthor>
        <RefAuthor> VAP Care Bundle Contributors</RefAuthor>
        <RefTitle>A European care bundle for prevention of ventilator-associated pneumonia</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>773-80</RefPage>
        <RefTotal>Rello J, Lode H, Cornaglia G, Masterton R; VAP Care Bundle Contributors. A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Med. 2010 May;36(5):773-80. DOI: 10.1007&#47;s00134-010-1841-5</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s00134-010-1841-5</RefLink>
      </Reference>
      <Reference refNo="38">
        <RefAuthor>Torres A</RefAuthor>
        <RefAuthor>Serra-Batlles J</RefAuthor>
        <RefAuthor>Ros E</RefAuthor>
        <RefAuthor>Piera C</RefAuthor>
        <RefAuthor>Puig de la Bellacasa J</RefAuthor>
        <RefAuthor>Cobos A</RefAuthor>
        <RefAuthor>Lome-a F</RefAuthor>
        <RefAuthor>Rodr&#237;guez-Roisin R</RefAuthor>
        <RefTitle>Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position</RefTitle>
        <RefYear>1992</RefYear>
        <RefJournal>Ann Intern Med</RefJournal>
        <RefPage>540-3</RefPage>
        <RefTotal>Torres A, Serra-Batlles J, Ros E, Piera C, Puig de la Bellacasa J, Cobos A, Lome-a F, Rodr&#237;guez-Roisin R. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med. 1992 Apr 1;116(7):540-3. DOI: 10.7326&#47;0003-4819-116-7-540</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.7326&#47;0003-4819-116-7-540</RefLink>
      </Reference>
      <Reference refNo="39">
        <RefAuthor>Esteban A</RefAuthor>
        <RefAuthor>Frutos F</RefAuthor>
        <RefAuthor>Tobin MJ</RefAuthor>
        <RefAuthor>Al&#237;a I</RefAuthor>
        <RefAuthor>Solsona JF</RefAuthor>
        <RefAuthor>Valverd&#250; I</RefAuthor>
        <RefAuthor>Fern&#225;ndez R</RefAuthor>
        <RefAuthor>de la Cal MA</RefAuthor>
        <RefAuthor>Benito S</RefAuthor>
        <RefAuthor>Tom&#225;s R</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group</RefTitle>
        <RefYear>1995</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>345-50</RefPage>
        <RefTotal>Esteban A, Frutos F, Tobin MJ, Al&#237;a I, Solsona JF, Valverd&#250; I, Fern&#225;ndez R, de la Cal MA, Benito S, Tom&#225;s R, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med. 1995 Feb 9;332(6):345-50. DOI: 10.1056&#47;NEJM199502093320601</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJM199502093320601</RefLink>
      </Reference>
      <Reference refNo="40">
        <RefAuthor>Esteban A</RefAuthor>
        <RefAuthor>Al&#237;a I</RefAuthor>
        <RefAuthor>Tobin MJ</RefAuthor>
        <RefAuthor>Gil A</RefAuthor>
        <RefAuthor>Gordo F</RefAuthor>
        <RefAuthor>Vallverd&#250; I</RefAuthor>
        <RefAuthor>Blanch L</RefAuthor>
        <RefAuthor>Bonet A</RefAuthor>
        <RefAuthor>V&#225;zquez A</RefAuthor>
        <RefAuthor>de Pablo R</RefAuthor>
        <RefAuthor>Torres A</RefAuthor>
        <RefAuthor>de La Cal MA</RefAuthor>
        <RefAuthor>Mac&#237;as S</RefAuthor>
        <RefTitle>Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Spanish Lung Failure Collaborative Group</RefTitle>
        <RefYear>1999</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>512-8</RefPage>
        <RefTotal>Esteban A, Al&#237;a I, Tobin MJ, Gil A, Gordo F, Vallverd&#250; I, Blanch L, Bonet A, V&#225;zquez A, de Pablo R, Torres A, de La Cal MA, Mac&#237;as S. Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med. 1999 Feb;159(2):512-8. DOI: 10.1164&#47;ajrccm.159.2.9803106</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;ajrccm.159.2.9803106</RefLink>
      </Reference>
      <Reference refNo="41">
        <RefAuthor>Reinhart K</RefAuthor>
        <RefAuthor>Brunkhorst FM</RefAuthor>
        <RefAuthor>Bone HG</RefAuthor>
        <RefAuthor>Bardutzky J</RefAuthor>
        <RefAuthor>Dempfle CE</RefAuthor>
        <RefAuthor>Forst H</RefAuthor>
        <RefAuthor></RefAuthor>
        <RefTitle>Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplin&#228;re Vereinigung f&#252;r Intensiv- und Notfallmedizin (DIVI))</RefTitle>
        <RefYear>2010</RefYear>
        <RefJournal>Ger Med Sci</RefJournal>
        <RefPage>Doc14</RefPage>
        <RefTotal>Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H, et al. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplin&#228;re Vereinigung f&#252;r Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci. 2010 Jun 28;8:Doc14. DOI: 10.3205&#47;000103</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.3205&#47;000103</RefLink>
      </Reference>
      <Reference refNo="42">
        <RefAuthor>Bochud PY</RefAuthor>
        <RefAuthor>Bonten M</RefAuthor>
        <RefAuthor>Marchetti O</RefAuthor>
        <RefAuthor>Calandra T</RefAuthor>
        <RefTitle>Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review</RefTitle>
        <RefYear>2004</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>S495-512</RefPage>
        <RefTotal>Bochud PY, Bonten M, Marchetti O, Calandra T. Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review. Crit Care Med. 2004 Nov;32(11 Suppl):S495-512. DOI: 10.1097&#47;01.CCM.0000143118.41100.14</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;01.CCM.0000143118.41100.14</RefLink>
      </Reference>
      <Reference refNo="43">
        <RefAuthor>Kumar A</RefAuthor>
        <RefAuthor>Roberts D</RefAuthor>
        <RefAuthor>Wood KE</RefAuthor>
        <RefAuthor>Light B</RefAuthor>
        <RefAuthor>Parrillo JE</RefAuthor>
        <RefAuthor>Sharma S</RefAuthor>
        <RefAuthor>Suppes R</RefAuthor>
        <RefAuthor>Feinstein D</RefAuthor>
        <RefAuthor>Zanotti S</RefAuthor>
        <RefAuthor>Taiberg L</RefAuthor>
        <RefAuthor>Gurka D</RefAuthor>
        <RefAuthor>Kumar A</RefAuthor>
        <RefAuthor>Cheang M</RefAuthor>
        <RefTitle>Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock</RefTitle>
        <RefYear>2006</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>1589-96</RefPage>
        <RefTotal>Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006 Jun;34(6):1589-96. DOI: 10.1097&#47;01.CCM.0000217961.75225.E9</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;01.CCM.0000217961.75225.E9</RefLink>
      </Reference>
      <Reference refNo="44">
        <RefAuthor>Nachtigall I</RefAuthor>
        <RefAuthor>Tamarkin A</RefAuthor>
        <RefAuthor>Tafelski S</RefAuthor>
        <RefAuthor>Deja M</RefAuthor>
        <RefAuthor>Halle E</RefAuthor>
        <RefAuthor>Gastmeier P</RefAuthor>
        <RefAuthor>Wernecke KD</RefAuthor>
        <RefAuthor>Bauer T</RefAuthor>
        <RefAuthor>Kastrup M</RefAuthor>
        <RefAuthor>Spies C</RefAuthor>
        <RefTitle>Impact of adherence to standard operating procedures for pneumonia on outcome of intensive care unit patients</RefTitle>
        <RefYear>2009</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>159-66</RefPage>
        <RefTotal>Nachtigall I, Tamarkin A, Tafelski S, Deja M, Halle E, Gastmeier P, Wernecke KD, Bauer T, Kastrup M, Spies C. Impact of adherence to standard operating procedures for pneumonia on outcome of intensive care unit patients. Crit Care Med. 2009 Jan;37(1):159-66. DOI: 10.1097&#47;CCM.0b013e3181934f1b</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;CCM.0b013e3181934f1b</RefLink>
      </Reference>
      <Reference refNo="45">
        <RefAuthor>Levy MM</RefAuthor>
        <RefAuthor>Fink MP</RefAuthor>
        <RefAuthor>Marshall JC</RefAuthor>
        <RefAuthor>Abraham E</RefAuthor>
        <RefAuthor>Angus D</RefAuthor>
        <RefAuthor>Cook D</RefAuthor>
        <RefAuthor>Cohen J</RefAuthor>
        <RefAuthor>Opal SM</RefAuthor>
        <RefAuthor>Vincent JL</RefAuthor>
        <RefAuthor>Ramsay G</RefAuthor>
        <RefAuthor> SCCM&#47;ESICM&#47;ACCP&#47;ATS&#47;SIS</RefAuthor>
        <RefTitle>2001 SCCM&#47;ESICM&#47;ACCP&#47;ATS&#47;SIS International Sepsis Definitions Conference</RefTitle>
        <RefYear>2003</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>1250-6</RefPage>
        <RefTotal>Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM&#47;ESICM&#47;ACCP&#47;ATS&#47;SIS. 2001 SCCM&#47;ESICM&#47;ACCP&#47;ATS&#47;SIS International Sepsis Definitions Conference. Crit Care Med. 2003 Apr;31(4):1250-6. DOI: 10.1097&#47;01.CCM.0000050454.01978.3B</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;01.CCM.0000050454.01978.3B</RefLink>
      </Reference>
      <Reference refNo="46">
        <RefAuthor>Fish DN</RefAuthor>
        <RefTitle>Optimal antimicrobial therapy for sepsis</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>Am J Health Syst Pharm</RefJournal>
        <RefPage>S13-9</RefPage>
        <RefTotal>Fish DN. Optimal antimicrobial therapy for sepsis. Am J Health Syst Pharm. 2002 Feb 15;59 (Suppl 1):S13-9.</RefTotal>
      </Reference>
      <Reference refNo="47">
        <RefAuthor>Hypothermia after Cardiac Arrest Study Group</RefAuthor>
        <RefTitle>Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>549-56</RefPage>
        <RefTotal>Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002 Feb 21;346(8):549-56. DOI: 10.1056&#47;NEJMoa012689</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJMoa012689</RefLink>
      </Reference>
      <Reference refNo="48">
        <RefAuthor>Bernard SA</RefAuthor>
        <RefAuthor>Gray TW</RefAuthor>
        <RefAuthor>Buist MD</RefAuthor>
        <RefAuthor>Jones BM</RefAuthor>
        <RefAuthor>Silvester W</RefAuthor>
        <RefAuthor>Gutteridge G</RefAuthor>
        <RefAuthor>Smith K</RefAuthor>
        <RefTitle>Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>N Engl J Med</RefJournal>
        <RefPage>557-63</RefPage>
        <RefTotal>Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002 Feb 21;346(8):557-63. DOI: 10.1056&#47;NEJMoa003289</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1056&#47;NEJMoa003289</RefLink>
      </Reference>
      <Reference refNo="49">
        <RefAuthor>Holzer M</RefAuthor>
        <RefAuthor>Bernard SA</RefAuthor>
        <RefAuthor>Hachimi-Idrissi S</RefAuthor>
        <RefAuthor>Roine RO</RefAuthor>
        <RefAuthor>Sterz F</RefAuthor>
        <RefAuthor>M&#252;llner M</RefAuthor>
        <RefAuthor> Collaborative Group on Induced Hypothermia for Neuroprotection After Cardiac Arrest</RefAuthor>
        <RefTitle>Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis</RefTitle>
        <RefYear>2005</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>414-8</RefPage>
        <RefTotal>Holzer M, Bernard SA, Hachimi-Idrissi S, Roine RO, Sterz F, M&#252;llner M; Collaborative Group on Induced Hypothermia for Neuroprotection After Cardiac Arrest. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med. 2005 Feb;33(2):414-8. DOI: 10.1097&#47;01.CCM.0000153410.87750.53</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;01.CCM.0000153410.87750.53</RefLink>
      </Reference>
      <Reference refNo="50">
        <RefAuthor>Wolfrum S</RefAuthor>
        <RefAuthor>Radke PW</RefAuthor>
        <RefAuthor>Pischon T</RefAuthor>
        <RefAuthor>Willich SN</RefAuthor>
        <RefAuthor>Schunkert H</RefAuthor>
        <RefAuthor>Kurowski V</RefAuthor>
        <RefTitle>Mild therapeutic hypothermia after cardiac arrest &#8211; a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>Resuscitation</RefJournal>
        <RefPage>207-13</RefPage>
        <RefTotal>Wolfrum S, Radke PW, Pischon T, Willich SN, Schunkert H, Kurowski V. Mild therapeutic hypothermia after cardiac arrest &#8211; a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units. Resuscitation. 2007 Feb;72(2):207-13. DOI: 10.1016&#47;j.resuscitation.2006.06.033</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.resuscitation.2006.06.033</RefLink>
      </Reference>
      <Reference refNo="51">
        <RefAuthor>Andersen HK</RefAuthor>
        <RefAuthor>Lewis SJ</RefAuthor>
        <RefAuthor>Thomas S</RefAuthor>
        <RefTitle>Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications</RefTitle>
        <RefYear>2006</RefYear>
        <RefJournal>Cochrane Database Syst Rev</RefJournal>
        <RefPage>CD004080</RefPage>
        <RefTotal>Andersen HK, Lewis SJ, Thomas S. Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004080.</RefTotal>
      </Reference>
      <Reference refNo="52">
        <RefAuthor>Heyland DK</RefAuthor>
        <RefAuthor>Dhaliwal R</RefAuthor>
        <RefAuthor>Drover JW</RefAuthor>
        <RefAuthor>Gramlich L</RefAuthor>
        <RefAuthor>Dodek P</RefAuthor>
        <RefAuthor> Canadian Critical Care Clinical Practice Guidelines Committee</RefAuthor>
        <RefTitle>Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients</RefTitle>
        <RefYear>2003</RefYear>
        <RefJournal>JPEN J Parenter Enteral Nutr</RefJournal>
        <RefPage>355-73</RefPage>
        <RefTotal>Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P; Canadian Critical Care Clinical Practice Guidelines Committee. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr. 2003 Sep-Oct;27(5):355-73. DOI: 10.1177&#47;0148607103027005355</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1177&#47;0148607103027005355</RefLink>
      </Reference>
      <Reference refNo="53">
        <RefAuthor>Kompan L</RefAuthor>
        <RefAuthor>Kremzar B</RefAuthor>
        <RefAuthor>Gadzijev E</RefAuthor>
        <RefAuthor>Prosek M</RefAuthor>
        <RefTitle>Effects of early enteral nutrition on intestinal permeability and the development of multiple organ failure after multiple injury</RefTitle>
        <RefYear>1999</RefYear>
        <RefJournal>Intensive Care Med</RefJournal>
        <RefPage>157-61</RefPage>
        <RefTotal>Kompan L, Kremzar B, Gadzijev E, Prosek M. Effects of early enteral nutrition on intestinal permeability and the development of multiple organ failure after multiple injury. Intensive Care Med. 1999 Feb;25(2):157-61. DOI: 10.1007&#47;s001340050809</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1007&#47;s001340050809</RefLink>
      </Reference>
      <Reference refNo="54">
        <RefAuthor>Kreymann KG</RefAuthor>
        <RefAuthor>Berger MM</RefAuthor>
        <RefAuthor>Deutz NE</RefAuthor>
        <RefAuthor>Hiesmayr M</RefAuthor>
        <RefAuthor>Jolliet P</RefAuthor>
        <RefAuthor>Kazandjiev G</RefAuthor>
        <RefAuthor>Nitenberg G</RefAuthor>
        <RefAuthor>van den Berghe G</RefAuthor>
        <RefAuthor>Wernerman J</RefAuthor>
        <RefAuthor> DGEM (German Society for Nutritional Medicine)</RefAuthor>
        <RefAuthor>Ebner C</RefAuthor>
        <RefAuthor>Hartl W</RefAuthor>
        <RefAuthor>Heymann C</RefAuthor>
        <RefAuthor>Spies C</RefAuthor>
        <RefAuthor> ESPEN (European Society for Parenteral and Enteral Nutrition)</RefAuthor>
        <RefTitle>ESPEN Guidelines on Enteral Nutrition: Intensive care</RefTitle>
        <RefYear>2006</RefYear>
        <RefJournal>Clin Nutr</RefJournal>
        <RefPage>210-23</RefPage>
        <RefTotal>Kreymann KG, Berger MM, Deutz NE, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J; DGEM (German Society for Nutritional Medicine), Ebner C, Hartl W, Heymann C, Spies C; ESPEN (European Society for Parenteral and Enteral Nutrition). ESPEN Guidelines on Enteral Nutrition: Intensive care. Clin Nutr. 2006 Apr;25(2):210-23. DOI: 10.1016&#47;j.clnu.2006.01.021</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;j.clnu.2006.01.021</RefLink>
      </Reference>
      <Reference refNo="55">
        <RefAuthor>Siegel MD</RefAuthor>
        <RefAuthor>Hayes E</RefAuthor>
        <RefAuthor>Vanderwerker LC</RefAuthor>
        <RefAuthor>Loseth DB</RefAuthor>
        <RefAuthor>Prigerson HG</RefAuthor>
        <RefTitle>Psychiatric illness in the next of kin of patients who die in the intensive care unit</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>1722-8</RefPage>
        <RefTotal>Siegel MD, Hayes E, Vanderwerker LC, Loseth DB, Prigerson HG. Psychiatric illness in the next of kin of patients who die in the intensive care unit. Crit Care Med. 2008 Jun;36(6):1722-8. DOI: 10.1097&#47;CCM.0b013e318174da72</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;CCM.0b013e318174da72</RefLink>
      </Reference>
      <Reference refNo="56">
        <RefAuthor>Kross EK</RefAuthor>
        <RefAuthor>Curtis JR</RefAuthor>
        <RefTitle>Burden of psychological symptoms and illness in family of critically ill patients: what is the relevance for critical care clinicians&#63;</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Crit Care Med</RefJournal>
        <RefPage>1955-6</RefPage>
        <RefTotal>Kross EK, Curtis JR. Burden of psychological symptoms and illness in family of critically ill patients: what is the relevance for critical care clinicians&#63;. Crit Care Med. 2008 Jun;36(6):1955-6. DOI: 10.1097&#47;CCM.0b013e31817616c0</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1097&#47;CCM.0b013e31817616c0</RefLink>
      </Reference>
      <Reference refNo="57">
        <RefAuthor>Curtis JR</RefAuthor>
        <RefAuthor>White DB</RefAuthor>
        <RefTitle>Practical guidance for evidence-based ICU family conferences</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Chest</RefJournal>
        <RefPage>835-43</RefPage>
        <RefTotal>Curtis JR, White DB. Practical guidance for evidence-based ICU family conferences. Chest. 2008 Oct;134(4):835-43. DOI: 10.1378&#47;chest.08-0235</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1378&#47;chest.08-0235</RefLink>
      </Reference>
      <Reference refNo="58">
        <RefAuthor>Gerstel E</RefAuthor>
        <RefAuthor>Engelberg RA</RefAuthor>
        <RefAuthor>Koepsell T</RefAuthor>
        <RefAuthor>Curtis JR</RefAuthor>
        <RefTitle>Duration of withdrawal of life support in the intensive care unit and association with family satisfaction</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>798-804</RefPage>
        <RefTotal>Gerstel E, Engelberg RA, Koepsell T, Curtis JR. Duration of withdrawal of life support in the intensive care unit and association with family satisfaction. Am J Respir Crit Care Med. 2008 Oct 15;178(8):798-804. DOI: 10.1164&#47;rccm.200711-1617OC</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.200711-1617OC</RefLink>
      </Reference>
      <Reference refNo="59">
        <RefAuthor>Wright AA</RefAuthor>
        <RefAuthor>Zhang B</RefAuthor>
        <RefAuthor>Ray A</RefAuthor>
        <RefAuthor>Mack JW</RefAuthor>
        <RefAuthor>Trice E</RefAuthor>
        <RefAuthor>Balboni T</RefAuthor>
        <RefAuthor>Mitchell SL</RefAuthor>
        <RefAuthor>Jackson VA</RefAuthor>
        <RefAuthor>Block SD</RefAuthor>
        <RefAuthor>Maciejewski PK</RefAuthor>
        <RefAuthor>Prigerson HG</RefAuthor>
        <RefTitle>Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>JAMA</RefJournal>
        <RefPage>1665-73</RefPage>
        <RefTotal>Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008 Oct 8;300(14):1665-73. DOI: 10.1001&#47;jama.300.14.1665</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1001&#47;jama.300.14.1665</RefLink>
      </Reference>
      <Reference refNo="60">
        <RefAuthor>Scheunemann LP</RefAuthor>
        <RefAuthor>McDevitt M</RefAuthor>
        <RefAuthor>Carson SS</RefAuthor>
        <RefAuthor>Hanson LC</RefAuthor>
        <RefTitle>Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review</RefTitle>
        <RefYear>2011</RefYear>
        <RefJournal>Chest</RefJournal>
        <RefPage>543-54</RefPage>
        <RefTotal>Scheunemann LP, McDevitt M, Carson SS, Hanson LC. Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review. Chest. 2011 Mar;139(3):543-54. DOI: 10.1378&#47;chest.10-0595</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1378&#47;chest.10-0595</RefLink>
      </Reference>
      <Reference refNo="61">
        <RefAuthor>Boyce JM</RefAuthor>
        <RefAuthor>Pittet D</RefAuthor>
        <RefAuthor> Healthcare Infection Control Practices Advisory Committee</RefAuthor>
        <RefAuthor> HICPAC&#47;SHEA&#47;APIC&#47;IDSA Hand Hygiene Task Force</RefAuthor>
        <RefTitle>Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC&#47;SHEA&#47;APIC&#47;IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America&#47;Association for Professionals in Infection Control&#47;Infectious Diseases Society of America</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>MMWR Recomm Rep</RefJournal>
        <RefPage>1-45, quiz CE1-4</RefPage>
        <RefTotal>Boyce JM, Pittet D; Healthcare Infection Control Practices Advisory Committee; HICPAC&#47;SHEA&#47;APIC&#47;IDSA Hand Hygiene Task Force. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC&#47;SHEA&#47;APIC&#47;IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America&#47;Association for Professionals in Infection Control&#47;Infectious Diseases Society of America. MMWR Recomm Rep. 2002 Oct 25;51(RR-16):1-45, quiz CE1-4. </RefTotal>
      </Reference>
      <Reference refNo="62">
        <RefAuthor>Erasmus V</RefAuthor>
        <RefAuthor>Brouwer W</RefAuthor>
        <RefAuthor>van Beeck EF</RefAuthor>
        <RefAuthor>Oenema A</RefAuthor>
        <RefAuthor>Daha TJ</RefAuthor>
        <RefAuthor>Richardus JH</RefAuthor>
        <RefAuthor>Vos MC</RefAuthor>
        <RefAuthor>Brug J</RefAuthor>
        <RefTitle>A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross-infection</RefTitle>
        <RefYear>2009</RefYear>
        <RefJournal>Infect Control Hosp Epidemiol</RefJournal>
        <RefPage>415-9</RefPage>
        <RefTotal>Erasmus V, Brouwer W, van Beeck EF, Oenema A, Daha TJ, Richardus JH, Vos MC, Brug J. A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross-infection. Infect Control Hosp Epidemiol. 2009 May;30(5):415-9. DOI: 10.1086&#47;596773</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1086&#47;596773</RefLink>
      </Reference>
      <Reference refNo="63">
        <RefAuthor>Parienti JJ</RefAuthor>
        <RefAuthor>Thibon P</RefAuthor>
        <RefAuthor>Heller R</RefAuthor>
        <RefAuthor>Le Roux Y</RefAuthor>
        <RefAuthor>von Theobald P</RefAuthor>
        <RefAuthor>Bensadoun H</RefAuthor>
        <RefAuthor>Bouvet A</RefAuthor>
        <RefAuthor>Lemarchand F</RefAuthor>
        <RefAuthor>Le Coutour X</RefAuthor>
        <RefAuthor> Antisepsie Chirurgicale des mains Study Group</RefAuthor>
        <RefTitle>Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>JAMA</RefJournal>
        <RefPage>722-7</RefPage>
        <RefTotal>Parienti JJ, Thibon P, Heller R, Le Roux Y, von Theobald P, Bensadoun H, Bouvet A, Lemarchand F, Le Coutour X; Antisepsie Chirurgicale des mains Study Group. Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study. JAMA. 2002 Aug 14;288(6):722-7. DOI: 10.1001&#47;jama.288.6.722</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1001&#47;jama.288.6.722</RefLink>
      </Reference>
      <Reference refNo="64">
        <RefAuthor>Pittet D</RefAuthor>
        <RefTitle>Clean hands reduce the burden of disease</RefTitle>
        <RefYear>2005</RefYear>
        <RefJournal>Lancet</RefJournal>
        <RefPage>185-7</RefPage>
        <RefTotal>Pittet D. Clean hands reduce the burden of disease. Lancet. 2005 Jul 16-22;366(9481):185-7. DOI: 10.1016&#47;S0140-6736(05)66886-9 </RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;S0140-6736(05)66886-9</RefLink>
      </Reference>
      <Reference refNo="65">
        <RefAuthor>Pittet D</RefAuthor>
        <RefAuthor>Dharan S</RefAuthor>
        <RefAuthor>Touveneau S</RefAuthor>
        <RefAuthor>Sauvan V</RefAuthor>
        <RefAuthor>Perneger TV</RefAuthor>
        <RefTitle>Bacterial contamination of the hands of hospital staff during routine patient care</RefTitle>
        <RefYear>1999</RefYear>
        <RefJournal>Arch Intern Med</RefJournal>
        <RefPage>821-6</RefPage>
        <RefTotal>Pittet D, Dharan S, Touveneau S, Sauvan V, Perneger TV. Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med. 1999 Apr 26;159(8):821-6. DOI: 10.1001&#47;archinte.159.8.821</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1001&#47;archinte.159.8.821</RefLink>
      </Reference>
      <Reference refNo="66">
        <RefAuthor>Pittet D</RefAuthor>
        <RefAuthor>Hugonnet S</RefAuthor>
        <RefAuthor>Harbarth S</RefAuthor>
        <RefAuthor>Mourouga P</RefAuthor>
        <RefAuthor>Sauvan V</RefAuthor>
        <RefAuthor>Touveneau S</RefAuthor>
        <RefAuthor>Perneger TV</RefAuthor>
        <RefTitle>Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme</RefTitle>
        <RefYear>2000</RefYear>
        <RefJournal>Lancet</RefJournal>
        <RefPage>1307-12</RefPage>
        <RefTotal>Pittet D, Hugonnet S, Harbarth S, Mourouga P, Sauvan V, Touveneau S, Perneger TV. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet. 2000 Oct 14;356(9238):1307-12.</RefTotal>
      </Reference>
      <Reference refNo="67">
        <RefAuthor>Pronovost PJ</RefAuthor>
        <RefAuthor>Angus DC</RefAuthor>
        <RefAuthor>Dorman T</RefAuthor>
        <RefAuthor>Robinson KA</RefAuthor>
        <RefAuthor>Dremsizov TT</RefAuthor>
        <RefAuthor>Young TL</RefAuthor>
        <RefTitle>Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review</RefTitle>
        <RefYear>2002</RefYear>
        <RefJournal>JAMA</RefJournal>
        <RefPage>2151-62</RefPage>
        <RefTotal>Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL. Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA. 2002 Nov 6;288(17):2151-62. DOI: 10.1001&#47;jama.288.17.2151</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1001&#47;jama.288.17.2151</RefLink>
      </Reference>
      <Reference refNo="68">
        <RefAuthor>Treggiari MM</RefAuthor>
        <RefAuthor>Martin DP</RefAuthor>
        <RefAuthor>Yanez ND</RefAuthor>
        <RefAuthor>Caldwell E</RefAuthor>
        <RefAuthor>Hudson LD</RefAuthor>
        <RefAuthor>Rubenfeld GD</RefAuthor>
        <RefTitle>Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury</RefTitle>
        <RefYear>2007</RefYear>
        <RefJournal>Am J Respir Crit Care Med</RefJournal>
        <RefPage>685-90</RefPage>
        <RefTotal>Treggiari MM, Martin DP, Yanez ND, Caldwell E, Hudson LD, Rubenfeld GD. Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Oct 1;176(7):685-90. DOI: 10.1164&#47;rccm.200701-165OC</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1164&#47;rccm.200701-165OC</RefLink>
      </Reference>
      <Reference refNo="69">
        <RefAuthor>Pham K</RefAuthor>
        <RefAuthor>Thornton JD</RefAuthor>
        <RefAuthor>Engelberg RA</RefAuthor>
        <RefAuthor>Jackson JC</RefAuthor>
        <RefAuthor>Curtis JR</RefAuthor>
        <RefTitle>Alterations during medical interpretation of ICU family conferences that interfere with or enhance communication</RefTitle>
        <RefYear>2008</RefYear>
        <RefJournal>Chest</RefJournal>
        <RefPage>109-16</RefPage>
        <RefTotal>Pham K, Thornton JD, Engelberg RA, Jackson JC, Curtis JR. Alterations during medical interpretation of ICU family conferences that interfere with or enhance communication. Chest. 2008 Jul;134(1):109-16. DOI: 10.1378&#47;chest.07-2852</RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1378&#47;chest.07-2852</RefLink>
      </Reference>
      <Reference refNo="70">
        <RefAuthor>Vincent JL</RefAuthor>
        <RefTitle>Need for intensivists in intensive-care units</RefTitle>
        <RefYear>2000</RefYear>
        <RefJournal>Lancet</RefJournal>
        <RefPage>695-6</RefPage>
        <RefTotal>Vincent JL. Need for intensivists in intensive-care units. Lancet. 2000 Aug 26;356(9231):695-6. DOI: 10.1016&#47;S0140-6736(00)02622-2 </RefTotal>
        <RefLink>http:&#47;&#47;dx.doi.org&#47;10.1016&#47;S0140-6736(00)02622-2</RefLink>
      </Reference>
    </References>
    <Media>
      <Tables>
        <NoOfTables>0</NoOfTables>
      </Tables>
      <Figures>
        <NoOfPictures>0</NoOfPictures>
      </Figures>
      <InlineFigures>
        <NoOfPictures>0</NoOfPictures>
      </InlineFigures>
      <Attachments>
        <Attachment>
          <MediaNo>1</MediaNo>
          <MediaID filename="000177.a1en.pdf" language="en" mimeType="application/pdf" origFilename="000177&#95;QualityIndicators.pdf" size="461089" url="">1en</MediaID>
          <MediaID filename="000177.a1de.pdf" language="de" mimeType="application/pdf" origFilename="000177&#95;Qualitaetsindikatoren.pdf" size="475638" url="">1de</MediaID>
          <AttachmentTitle language="en">Quality Indicators in Intensive Care Medicine</AttachmentTitle>
          <AttachmentTitle language="de">Qualit&#228;tsindikatoren Intensivmedizin</AttachmentTitle>
        </Attachment>
        <NoOfAttachments>1</NoOfAttachments>
      </Attachments>
    </Media>
  </OrigData>
</GmsArticle>