iprs000178
10.3205/iprs000178
urn:nbn:de:0183-iprs0001780
Case Report
Localized pigmented villo-nodular synovitis of trochanteric bursa
Circumscripte pigmentierte villo-noduläre Synovitis der Bursa trochanterica
Bruns
Bruns
Juergen
J
Prof. Dr. med.
Wilhelmsburger Krankenhaus Groß-Sand, Groß-Sand 3, 21107 Hamburg, GermanyDept. of Orthopedic Surgery, Wilhelmsburg Hospital Groß-Sand, Hamburg, Germany
juergen-b-bruns@web.de
author
Rosenbaum
Rosenbaum
Benedikt
B
Dept. of Radiology, Wilhelmsburg Hospital Groß-Sand, Hamburg, Germany
author
Thorns
Thorns
Christoph
C
Dept. of Pathology, Marienkrankenhaus Hamburg, Germany
author
German Medical Science GMS Publishing House
Düsseldorf
610
pigmented villo-nodular synovitis
PVNS
tenosynovial giant cell tumors
TSGCT
circumscribed
diffuse
bursa
bursa trochanterica
pigmentierte villo-noduläre Synovitis
PVNS
TSGCT
circumscript
diffus
Bursa
Bursa trochanterica
20231013
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
2193-8091
12
GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
GMS Interdiscip Plast Reconstr Surg DGPW
08
Dies ist der erste Bericht über eine pigmentierte villo-noduläre Synovitis (PVNS) vom circumscripten Typ in der Bursa trochanterica. Am häufigsten tritt die PVNS in Knie-, Sprung- und Hüftgelenken entweder als circumscripte oder diffuse Form auf. Im Prinzip kann die PVNS in allen synovialen Strukturen auftreten. In Bursen tritt die PVNS äußerst selten auf. Weniger als 25 Berichte gibt es bisher über das Auftreten einer PVNS in einer Bursa. Dies ist, soweit bekannt, der Erste über den Befall der Bursa trochanterica.Auffällig bei diesem Fall ist, dass die Zeit zwischen dem Auftreten erster Symptome bis zur endgültigen Diagnosestellung mit 7 Jahren sehr lang und die Patientin mit 75 Jahren deutlich älter war als andere Patienten mit PVNS.Therapeutisch erfolgte eine komplette operative Resektion der Bursa trochanterica. Nach dreieinhalb Jahren postoperativ ist die Patientin frei von Symptomen und Rezidiven.
This is the first report on a localized pigmented villo-nodular synovitis (PVNS or TSGCT) occurring in the trochanteric bursa. Bursal involvement in PVNS is extremely rare. Most often PVNS occurs either as a localized or diffuse lesion in a major synovial joint, such as the knee, ankle joint or hip joint. In principle, all synovial structures can be involved. The case reported here is remarkable regarding the long period between the occurrence of the first symptoms and the final diagnosis as well as the age of the female patient (75 yrs).Therapeutically a complete resection was performed in order to avoid recurrence. More then three years later the patient did well and there has been no evidence of recurrence yet.
Case descriptionPreoperative findingsA 75-year-old female had been suffering from a fluctuating soft tissue mass on her lateral proximal thigh for seven years. Prior to the symptoms she had fallen on her left trochanter. Primary treatment was done symptomatically. Due to the long-lasting symptoms a MRI was finally performed exhibiting the findings mentioned below. The patient was admitted without any clinical signs of infection, an almost normal gait-pattern and a free range of motion of the ipsilateral hip joint. White blood cells (WBC) and C-reactive protein (CRP) were within normal range. ImagingLateral to the greater trochanter in the bursa trochanterica there was evidence of fluid showing homogeneous hyperintensity without sedimentation in fluid-sensitive sequences. Proton-weighted imaging revealed two nodular wall extensions in teardrop shape extending craniolaterally. These extensions measured a maximum of 1 cm at the base. In addition, at the roof of the fluid-filled cavity there was a space measuring approximately 1.5 x 0.<![CDATA[5 c</PlainText></TextGroup>m. In the native fat-suppressed T1 turbospinecho sequence, this space-occupying lesion was partially hyperintense. This was considered to be hemosiderin. After application of gadolinium, there was a vigorous enhancement of the lining of the height. In addition, there was diffuse enhancement of the muscles in the immediate vicinity of the bursa. The hemorrhaged mass showed no enhancement of the contrast medium. In summary, the recent MRI exhibited an enlarged trochanteric bursitis with some intrabursal soft tissue formation suspicious for pigmented villo-nodular synovitis (PVNS) of the bursa trochanteric (PVNSBT) (Figure 1 <ImgLink imgNo="1" imgType="figure"/>, Figure 2 <ImgLink imgNo="2" imgType="figure"/>, Figure 3 <ImgLink imgNo="3" imgType="figure"/>, Figure 4 <ImgLink imgNo="4" imgType="figure"/>). </Pgraph><SubHeadline>Intraoperative findings</SubHeadline><Pgraph>The enlarged trochanteric bursa exhibited several lacunae with a thickened synovial layer in terms of an unspecific synovitis and parts showing villo-nodular yellowish to brownish synovitic changes to the extensions already visable in the MRI. Furthermore, the medial glutaeus muscle exhibited degenerative lipomatous changes, probably as a sequela of her previous trauma. Therapeutically a complete resection of the trochantic bursa was performed to ensure total resection of PVNSBT tissue. Histologically PVNS of the bursa was confirmed without any signs of malignancy. Postoperatively the patient recovered well. </Pgraph><SubHeadline>Follow-up</SubHeadline><Pgraph>At final follow-up three and a half years postoperatively, no signs of recurrence could be detected with a follow-up MRI. Clinically the patient exhibited a slight limping owing to the weakness of the medial glutaeus muscle. </Pgraph></TextBlock>
<TextBlock linked="yes" name="Discussion">
<MainHeadline>Discussion</MainHeadline><Pgraph>Pigmented villo-nodular synovitis (PVNS) and/or giant-cell tumors of tendon sheaths / tenosynovial giant cell tumors (TSGCT) are rare diseases of synovial tissue occurring most often in synovial joints such as knee and ankle joints <TextLink reference="1"></TextLink>, <TextLink reference="2"></TextLink>, <TextLink reference="3"></TextLink>, <TextLink reference="4"></TextLink>, <TextLink reference="5"></TextLink>. </Pgraph><Pgraph>Apart from synovial joints in principle all synovial structures <TextLink reference="6"></TextLink> such as teno-synovial tissue and bursa can be involved. Sometimes the synovial origin of the tumor is unclear: for example in the supraclavicular fossa <TextLink reference="7"></TextLink>, infratemporal fossa <TextLink reference="8"></TextLink>, quadriceps muscle <TextLink reference="9"></TextLink>, subcutaneous thigh <TextLink reference="10"></TextLink>, or unknown <TextLink reference="6"></TextLink>.</Pgraph><Pgraph>The incidence is reported to be about 1–2/million <TextLink reference="11"></TextLink>, <TextLink reference="12"></TextLink>, <TextLink reference="13"></TextLink>. A more recent analysis exhibited a distinctly higher incidence: based on patients from the Netherlands Maastboom et al. <TextLink reference="14"></TextLink> estimated the worldwide incidence: in their analysis digits were involved most often [29/million], followed by localized TSGCT in the extremities [10/ million] and 4/million for the diffuse type <TextLink reference="14"></TextLink>. Furthermore, they found that the recurrence rate in diffuse types was 2.6 times higher compared to localized PVNS in the extremities.</Pgraph><Pgraph>Jaffe et al. <TextLink reference="15"></TextLink> were, to our knowledge, the first to report on this particular disease. There were several synonyma, but meanwhile the terms teno-synovial giant-cell tumor (TSGCT) and/or villo-nodular synovitis (PVNS) are widely used <TextLink reference="16"></TextLink>. Two different types of occurrence can be differentiated: the circumscribed type and the diffuse one <TextLink reference="17"></TextLink>. </Pgraph><Pgraph>PVNS is mostly an intraarticular process but may also expand towards the extraarticular vicinity of the involved joint. Other joints such as shoulder and elbow joint, the wrist, fingers, subtarsal joint, other joints of the foot, the temporo-mandibular and the infratemporal fossa <TextLink reference="8"></TextLink>, <TextLink reference="16"></TextLink>, <TextLink reference="17"></TextLink>, <TextLink reference="18"></TextLink>, <TextLink reference="19"></TextLink> are rarely involved. An extremely rare occurrence was seen in joints of the vertebral column, mostly the facet joints but also even the iliosacral area and the sacrum <TextLink reference="20"></TextLink>, <TextLink reference="21"></TextLink>, <TextLink reference="22"></TextLink>, <TextLink reference="23"></TextLink>, <TextLink reference="24"></TextLink>.</Pgraph><Pgraph>Due to the osteolytic capability of giant-cells in PVNS the tumor can invade bone and produce osteolytic lacunae in these bones <TextLink reference="25"></TextLink>, <TextLink reference="26"></TextLink>, <TextLink reference="27"></TextLink>, <TextLink reference="28"></TextLink> or even invade other anatomical bony structures as reported by Son et al. <TextLink reference="29"></TextLink>, who treated a diffuse PVNS located in the temporal area invading the skull followed by destruction of the brain parenchyma. In single case reports rare locations such as an intramuscular lesion of the quadriceps muscle or even a subcutaneous location far away from any synovial structure have been reported as well as PVNS tissue occurring in the external auditory canal <TextLink reference="9"></TextLink>, <TextLink reference="10"></TextLink>, <TextLink reference="30"></TextLink>. </Pgraph><Pgraph>Rarely, a multilocular articular occurrence is reported <TextLink reference="31"></TextLink>, <TextLink reference="32"></TextLink>. In addition, similar to giant cell tumors of bone <TextLink reference="33"></TextLink> even benign PVNS lesions can metastasize to regional lymph-nodes or to the lung <TextLink reference="34"></TextLink>, <TextLink reference="35"></TextLink>, <TextLink reference="36"></TextLink>. A simultan<TextGroup><PlainText>e</PlainText></TextGroup>ous appearance of PVNS with synovial chondromatosis of the hip has been reported by Efrima et al. <TextLink reference="37"></TextLink>. </Pgraph><Pgraph>Even in metastasing cases the primary lesions may normally exhibit no signs of malignancy. Benign but aggressive PVNS is mostly seen in adults aged between 20 and 50 years, but even in children this lesion has been found <TextLink reference="13"></TextLink>, <TextLink reference="38"></TextLink>, <TextLink reference="39"></TextLink>, <TextLink reference="40"></TextLink>. In contrast, primary malignant PVNS is extremely rare. Fewer than 20 cases have been reported as yet <TextLink reference="24"></TextLink>, <TextLink reference="41"></TextLink>, <TextLink reference="42"></TextLink>.</Pgraph><Pgraph>The occurence in bursa has been described only once so far <TextLink reference="43"></TextLink>. Only case reports on involved bursa have been reported (see below). In a binational analysis on 173 patients suffering from PVNS or TSGCT a bursal involvement was seen in only 4% of either the diffuse or localized type <TextLink reference="43"></TextLink>. In principle, all bursa around the acromium, olecranon, iliopsoas muscle, fingers, toes, temporomandibular region and elsewhere can be affected <TextLink reference="15"></TextLink>, <TextLink reference="44"></TextLink>, <TextLink reference="45"></TextLink>, <TextLink reference="46"></TextLink>, <TextLink reference="47"></TextLink>. The one involved most often was the anserine bursa <TextLink reference="45"></TextLink>, <TextLink reference="46"></TextLink>, <TextLink reference="47"></TextLink>. Other bursae such as the suprapatellar, subacromial and ileopectinal bursa are rarely involved <TextLink reference="48"></TextLink>, <TextLink reference="49"></TextLink>, <TextLink reference="50"></TextLink>. Others reported a case where PVS was located in a popliteal cyst <TextLink reference="51"></TextLink>, but anatomically this is not a true bursa. </Pgraph><Pgraph>Apart from the hip joint there is only one report of PVNSB involving the iliopectineal bursa in the region of the hip <TextLink reference="52"></TextLink>. </Pgraph><Pgraph>Regarding the diagnostic procedure, the most important issue seems to be to remember such a rare disease. I<TextGroup><PlainText>n a</PlainText></TextGroup>ddition, this case showed two specialities: the age o<TextGroup><PlainText>f t</PlainText></TextGroup>he patient was very high and the bursa trochanteric, normally a very small bursa, was extremely enlarged and contained “normal” infected synovial tissue parallel to PVNS synovitis with the typical macroscopic changes such as pigmentation, villi and noduli. The rarity of this location might have caused the long period between onset of symptoms and final diagnosis and immediate treatment. </Pgraph><Pgraph>As for many other cases it is well-known that patients suffer for a long time before the final diagnosis is made as they experience unspecific symptoms such as tenderness, joint effusion, swelling and a limited range of motion. </Pgraph><Pgraph>Regarding imaging procedures MRI has a central role in the identification of both the extra- and intraarticular tumors <TextLink reference="53"></TextLink>, <TextLink reference="54"></TextLink>. PVNS mostly exhibits typical characteris<TextGroup><PlainText>t</PlainText></TextGroup>ics described above and in the literature <TextLink reference="53"></TextLink>, <TextLink reference="54"></TextLink>. CT<TextGroup><PlainText>-</PlainText></TextGroup>scans might be helpful for the detection of a bony involvement in intra- and extraarticular diseases <TextLink reference="55"></TextLink>. </Pgraph><Pgraph>The current treatment of choice for both the extraarticular diffuse and localized type of PVNS as well as for TSGCT is the complete surgical removal of the tumor masses if possible <TextLink reference="56"></TextLink>, <TextLink reference="57"></TextLink>, <TextLink reference="58"></TextLink>. </Pgraph><Pgraph>In primary circumscribed tumors of either location (intra- or extrarticular) additional adjuvant therapeutical procedures such as external radiation or radiosynovectomy with isotopes do not seem to be indicated, and neither are new medical targeted therapies such as imitanib or similar medications.</Pgraph><Pgraph>In contrast, for the diffuse type an additional adjuvant therapy such as postoperative radiotherapy <TextLink reference="1"></TextLink>, <TextLink reference="2"></TextLink>, <TextLink reference="59"></TextLink> or radiosynoviorthesis has been used at times in order to reduce the recurrence rate <TextLink reference="60"></TextLink>.</Pgraph></TextBlock>
<TextBlock linked="yes" name="Conclusion">
<MainHeadline>Conclusion</MainHeadline><Pgraph>PVNS is a very rare disease of synovial joints or other synovial structures containing synivial tissue such as tendon sheaths, and involvement of bursa is extremely rare. We report the first case involving the trochanteric bursa in a 75-year-old woman, who had suffered for seven years before being diagnosed. This indicates that the awareness of such a bursal lesion is most important to shorten the time until the final diagnosis is made. </Pgraph></TextBlock>
<TextBlock linked="yes" name="Notes">
<MainHeadline>Notes</MainHeadline><SubHeadline>Competing interests</SubHeadline><Pgraph>The authors declare that they have no competing interests.</Pgraph></TextBlock>
<References linked="yes">
<Reference refNo="1">
<RefAuthor>Ottaviani S</RefAuthor>
<RefAuthor>Ayral X</RefAuthor>
<RefAuthor>Dougados M</RefAuthor>
<RefAuthor>Gossec L</RefAuthor>
<RefTitle>Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature</RefTitle>
<RefYear>2011</RefYear>
<RefJournal>Semin Arthritis Rheum</RefJournal>
<RefPage>539-46</RefPage>
<RefTotal>Ottaviani S, Ayral X, Dougados M, Gossec L. Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. Semin Arthritis Rheum. 2011 Jun;40(6):539-46. DOI: 10.1016/j.semarthrit.2010.07.005</RefTotal>
<RefLink>https://doi.org/10.1016/j.semarthrit.2010.07.005</RefLink>
</Reference>
<Reference refNo="2">
<RefAuthor>Mollon B</RefAuthor>
<RefAuthor>Lee A</RefAuthor>
<RefAuthor>Busse JW</RefAuthor>
<RefAuthor>Griffin AM</RefAuthor>
<RefAuthor>Ferguson PC</RefAuthor>
<RefAuthor>Wunder JS</RefAuthor>
<RefAuthor>Theodoropoulos J</RefAuthor>
<RefTitle>The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>Bone Joint J</RefJournal>
<RefPage>550-7</RefPage>
<RefTotal>Mollon B, Lee A, Busse JW, Griffin AM, Ferguson PC, Wunder JS, Theodoropoulos J. The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. Bone Joint J. 2015 Apr;97-B(4):550-7.
DOI: 10.1302/0301-620X.97B4.34907</RefTotal>
<RefLink>https://doi.org/10.1302/0301-620X.97B4.34907</RefLink>
</Reference>
<Reference refNo="3">
<RefAuthor>Guo Q</RefAuthor>
<RefAuthor>Shi W</RefAuthor>
<RefAuthor>Jiao C</RefAuthor>
<RefAuthor>Xie X</RefAuthor>
<RefAuthor>Jiang D</RefAuthor>
<RefAuthor>Hu Y</RefAuthor>
<RefTitle>Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often?</RefTitle>
<RefYear>2018</RefYear>
<RefJournal>Knee Surg Sports Traumatol Arthrosc</RefJournal>
<RefPage>3118-23</RefPage>
<RefTotal>Guo Q, Shi W, Jiao C, Xie X, Jiang D, Hu Y. Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? Knee Surg Sports Traumatol Arthrosc. 2018 Oct;26(10):3118-23. DOI: 10.1007/s00167-017-4488-8</RefTotal>
<RefLink>https://doi.org/10.1007/s00167-017-4488-8</RefLink>
</Reference>
<Reference refNo="4">
<RefAuthor>Cattelan M</RefAuthor>
<RefAuthor>Bonnomet F</RefAuthor>
<RefAuthor>Bierry G</RefAuthor>
<RefAuthor>Di Marco A</RefAuthor>
<RefAuthor>Brinkert D</RefAuthor>
<RefAuthor>Adam P</RefAuthor>
<RefAuthor>Ehlinger M</RefAuthor>
<RefTitle>Villonodular synovitis of the ankle. Analysis of the risk of recurrence</RefTitle>
<RefYear>2016</RefYear>
<RefJournal>Orthop Traumatol Surg Res</RefJournal>
<RefPage>639-44</RefPage>
<RefTotal>Cattelan M, Bonnomet F, Bierry G, Di Marco A, Brinkert D, Adam P, Ehlinger M. Villonodular synovitis of the ankle. Analysis of the risk of recurrence. Orthop Traumatol Surg Res. 2016 Sep;102(5):639-44. DOI: 10.1016/j.otsr.2016.03.016</RefTotal>
<RefLink>https://doi.org/10.1016/j.otsr.2016.03.016</RefLink>
</Reference>
<Reference refNo="5">
<RefAuthor>Pianosi K</RefAuthor>
<RefAuthor>Rigby M</RefAuthor>
<RefAuthor>Hart R</RefAuthor>
<RefAuthor>Trites J</RefAuthor>
<RefAuthor>Taylor SM</RefAuthor>
<RefTitle>Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation</RefTitle>
<RefYear>2016</RefYear>
<RefJournal>Plast Reconstr Surg Glob Open</RefJournal>
<RefPage>e674</RefPage>
<RefTotal>Pianosi K, Rigby M, Hart R, Trites J, Taylor SM. Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. Plast Reconstr Surg Glob Open. 2016 Apr;4(4):e674. DOI: 10.1097/GOX.0000000000000658</RefTotal>
<RefLink>https://doi.org/10.1097/GOX.0000000000000658</RefLink>
</Reference>
<Reference refNo="6">
<RefAuthor>Albergo JI</RefAuthor>
<RefAuthor>Gaston CL</RefAuthor>
<RefAuthor>Davies M</RefAuthor>
<RefAuthor>Abudu AT</RefAuthor>
<RefAuthor>Carter SR</RefAuthor>
<RefAuthor>Jeys LM</RefAuthor>
<RefAuthor>Tillman RM</RefAuthor>
<RefAuthor>Grimer RJ</RefAuthor>
<RefTitle>Hoffa's fat pad tumours: what do we know about them?</RefTitle>
<RefYear>2013</RefYear>
<RefJournal>Int Orthop</RefJournal>
<RefPage>2225-9</RefPage>
<RefTotal>Albergo JI, Gaston CL, Davies M, Abudu AT, Carter SR, Jeys LM, Tillman RM, Grimer RJ. Hoffa's fat pad tumours: what do we know about them? Int Orthop. 2013 Nov;37(11):2225-9.
DOI: 10.1007/s00264-013-2041-z</RefTotal>
<RefLink>https://doi.org/10.1007/s00264-013-2041-z</RefLink>
</Reference>
<Reference refNo="7">
<RefAuthor>Arastu MH</RefAuthor>
<RefAuthor>Milani R</RefAuthor>
<RefAuthor>Davidson AW</RefAuthor>
<RefAuthor>Bousdras K</RefAuthor>
<RefAuthor>Sinisi M</RefAuthor>
<RefTitle>Pigmented villo-nodular synovitis: a rare cause of a supra-clavicular fossa mass</RefTitle>
<RefYear>2007</RefYear>
<RefJournal>Eur J Surg Oncol</RefJournal>
<RefPage>812-4</RefPage>
<RefTotal>Arastu MH, Milani R, Davidson AW, Bousdras K, Sinisi M. Pigmented villo-nodular synovitis: a rare cause of a supra-clavicular fossa mass. Eur J Surg Oncol. 2007 Aug;33(6):812-4. DOI: 10.1016/j.ejso.2006.05.020</RefTotal>
<RefLink>https://doi.org/10.1016/j.ejso.2006.05.020</RefLink>
</Reference>
<Reference refNo="8">
<RefAuthor>Gong ZC</RefAuthor>
<RefAuthor>Lin ZQ</RefAuthor>
<RefAuthor>Moming A</RefAuthor>
<RefAuthor>Ling B</RefAuthor>
<RefAuthor>Liu H</RefAuthor>
<RefAuthor>Hu M</RefAuthor>
<RefAuthor>Long X</RefAuthor>
<RefTitle>Extra-articular diffuse tenosynovial giant cell tumour of the infratemporal fossa: report of a case and literature review</RefTitle>
<RefYear>2010</RefYear>
<RefJournal>Int J Oral Maxillofac Surg</RefJournal>
<RefPage>820-4</RefPage>
<RefTotal>Gong ZC, Lin ZQ, Moming A, Ling B, Liu H, Hu M, Long X. Extra-articular diffuse tenosynovial giant cell tumour of the infratemporal fossa: report of a case and literature review. Int J Oral Maxillofac Surg. 2010 Aug;39(8):820-4.
DOI: 10.1016/j.ijom.2010.02.026</RefTotal>
<RefLink>https://doi.org/10.1016/j.ijom.2010.02.026</RefLink>
</Reference>
<Reference refNo="9">
<RefAuthor>Rateb K</RefAuthor>
<RefAuthor>Hassen BG</RefAuthor>
<RefAuthor>Leila A</RefAuthor>
<RefAuthor>Faten F</RefAuthor>
<RefAuthor>Med Samir D</RefAuthor>
<RefTitle>Giant cell tumor of soft tissues: A case report of extra-articular diffuse-type giant cell tumor of the quadriceps</RefTitle>
<RefYear>2017</RefYear>
<RefJournal>Int J Surg Case Rep</RefJournal>
<RefPage>245-9</RefPage>
<RefTotal>Rateb K, Hassen BG, Leila A, Faten F, Med Samir D. Giant cell tumor of soft tissues: A case report of extra-articular diffuse-type giant cell tumor of the quadriceps. Int J Surg Case Rep. 2017;31:245-9. DOI: 10.1016/j.ijscr.2016.12.019</RefTotal>
<RefLink>https://doi.org/10.1016/j.ijscr.2016.12.019</RefLink>
</Reference>
<Reference refNo="10">
<RefAuthor>Sanghvi DA</RefAuthor>
<RefAuthor>Purandare NC</RefAuthor>
<RefAuthor>Jambhekar NA</RefAuthor>
<RefAuthor>Agarwal MG</RefAuthor>
<RefAuthor>Agarwal A</RefAuthor>
<RefTitle>Diffuse-type giant cell tumor of the subcutaneous thigh</RefTitle>
<RefYear>2007</RefYear>
<RefJournal>Skeletal Radiol</RefJournal>
<RefPage>327-30</RefPage>
<RefTotal>Sanghvi DA, Purandare NC, Jambhekar NA, Agarwal MG, Agarwal A. Diffuse-type giant cell tumor of the subcutaneous thigh. Skeletal Radiol. 2007 Apr;36(4):327-30. DOI: 10.1007/s00256-006-0112-6</RefTotal>
<RefLink>https://doi.org/10.1007/s00256-006-0112-6</RefLink>
</Reference>
<Reference refNo="11">
<RefAuthor>Bravo SM</RefAuthor>
<RefAuthor>Winalski CS</RefAuthor>
<RefAuthor>Weissman BN</RefAuthor>
<RefTitle>Pigmented villonodular synovitis</RefTitle>
<RefYear>1996</RefYear>
<RefJournal>Radiol Clin North Am</RefJournal>
<RefPage>311-26, x-xi</RefPage>
<RefTotal>Bravo SM, Winalski CS, Weissman BN. Pigmented villonodular synovitis. Radiol Clin North Am. 1996 Mar;34(2):311-26, x-xi.</RefTotal>
</Reference>
<Reference refNo="12">
<RefAuthor>Lin J</RefAuthor>
<RefAuthor>Jacobson JA</RefAuthor>
<RefAuthor>Jamadar DA</RefAuthor>
<RefAuthor>Ellis JH</RefAuthor>
<RefTitle>Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings</RefTitle>
<RefYear>1999</RefYear>
<RefJournal>AJR Am J Roentgenol</RefJournal>
<RefPage>191-7</RefPage>
<RefTotal>Lin J, Jacobson JA, Jamadar DA, Ellis JH. Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings. AJR Am J Roentgenol. 1999 Jan;172(1):191-7.
DOI: 10.2214/ajr.172.1.9888766</RefTotal>
<RefLink>https://doi.org/10.2214/ajr.172.1.9888766</RefLink>
</Reference>
<Reference refNo="13">
<RefAuthor>Karami M</RefAuthor>
<RefAuthor>Soleimani M</RefAuthor>
<RefAuthor>Shiari R</RefAuthor>
<RefTitle>Pigmented villonodular synovitis in pediatric population: review of literature and a case report</RefTitle>
<RefYear>2018</RefYear>
<RefJournal>Pediatr Rheumatol Online J</RefJournal>
<RefPage>6</RefPage>
<RefTotal>Karami M, Soleimani M, Shiari R. Pigmented villonodular synovitis in pediatric population: review of literature and a case report. Pediatr Rheumatol Online J. 2018 Jan;16(1):6.
DOI: 10.1186/s12969-018-0222-4</RefTotal>
<RefLink>https://doi.org/10.1186/s12969-018-0222-4</RefLink>
</Reference>
<Reference refNo="14">
<RefAuthor>Mastboom MJL</RefAuthor>
<RefAuthor>Verspoor FGM</RefAuthor>
<RefAuthor>Verschoor AJ</RefAuthor>
<RefAuthor>Uittenbogaard D</RefAuthor>
<RefAuthor>Nemeth B</RefAuthor>
<RefAuthor>Mastboom WJB</RefAuthor>
<RefAuthor>Bovée JVMG</RefAuthor>
<RefAuthor>Dijkstra PDS</RefAuthor>
<RefAuthor>Schreuder HWB</RefAuthor>
<RefAuthor>Gelderblom H</RefAuthor>
<RefAuthor>Van de Sande MAJ</RefAuthor>
<RefAuthor> TGCT study group</RefAuthor>
<RefTitle>Higher incidence rates than previously known in tenosynovial giant cell tumors</RefTitle>
<RefYear>2017</RefYear>
<RefJournal>Acta Orthop</RefJournal>
<RefPage>688-94</RefPage>
<RefTotal>Mastboom MJL, Verspoor FGM, Verschoor AJ, Uittenbogaard D, Nemeth B, Mastboom WJB, Bovée JVMG, Dijkstra PDS, Schreuder HWB, Gelderblom H, Van de Sande MAJ; TGCT study group. Higher incidence rates than previously known in tenosynovial giant cell tumors. Acta Orthop. 2017 Dec;88(6):688-94.
DOI: 10.1080/17453674.2017.1361126</RefTotal>
<RefLink>https://doi.org/10.1080/17453674.2017.1361126</RefLink>
</Reference>
<Reference refNo="15">
<RefAuthor>Jaffe HL</RefAuthor>
<RefAuthor>Lichtenstein L</RefAuthor>
<RefAuthor>Sutro CJ</RefAuthor>
<RefTitle>Pigmented villonodular synovitis, bursitis and tenosynovitis. A discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xanthoma, xanthogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath, with some consideration of this tendon sheath lesion itself</RefTitle>
<RefYear>1941</RefYear>
<RefJournal>Arch Pathol</RefJournal>
<RefPage>731-65</RefPage>
<RefTotal>Jaffe HL, Lichtenstein L, Sutro CJ. Pigmented villonodular synovitis, bursitis and tenosynovitis. A discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xanthoma, xanthogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath, with some consideration of this tendon sheath lesion itself. Arch Pathol. 1941;31:731-65.</RefTotal>
</Reference>
<Reference refNo="16">
<RefAuthor>Kwon M</RefAuthor>
<RefAuthor>Bang JY</RefAuthor>
<RefAuthor>Nam KH</RefAuthor>
<RefTitle>Rapid destruction of shoulder joint by pigmented villonodular synovitis treated by hemiarthroplasty: A case report</RefTitle>
<RefYear>2020</RefYear>
<RefJournal>Int J Surg Case Rep</RefJournal>
<RefPage>138-42</RefPage>
<RefTotal>Kwon M, Bang JY, Nam KH. Rapid destruction of shoulder joint by pigmented villonodular synovitis treated by hemiarthroplasty: A case report. Int J Surg Case Rep. 2020;77:138-42.
DOI: 10.1016/j.ijscr.2020.10.128</RefTotal>
<RefLink>https://doi.org/10.1016/j.ijscr.2020.10.128</RefLink>
</Reference>
<Reference refNo="17">
<RefAuthor>Kwon JH</RefAuthor>
<RefAuthor>Han JH</RefAuthor>
<RefAuthor>Almeida VR</RefAuthor>
<RefAuthor>Kim SH</RefAuthor>
<RefAuthor>Park HJ</RefAuthor>
<RefAuthor>Nha KW</RefAuthor>
<RefTitle>Localized pigmented villonodular synovitis of the proximal tibiofibular joint</RefTitle>
<RefYear>2014</RefYear>
<RefJournal>Knee Surg Relat Res</RefJournal>
<RefPage>249-52</RefPage>
<RefTotal>Kwon JH, Han JH, Almeida VR, Kim SH, Park HJ, Nha KW. Localized pigmented villonodular synovitis of the proximal tibiofibular joint. Knee Surg Relat Res. 2014 Dec;26(4):249-52. DOI: 10.5792/ksrr.2014.26.4.249</RefTotal>
<RefLink>https://doi.org/10.5792/ksrr.2014.26.4.249</RefLink>
</Reference>
<Reference refNo="18">
<RefAuthor>Sharma H</RefAuthor>
<RefAuthor>Jane MJ</RefAuthor>
<RefAuthor>Reid R</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry</RefTitle>
<RefYear>2006</RefYear>
<RefJournal>J Foot Ankle Surg</RefJournal>
<RefPage>329-36</RefPage>
<RefTotal>Sharma H, Jane MJ, Reid R. Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry. J Foot Ankle Surg. 2006;45(5):329-36.
DOI: 10.1053/j.jfas.2006.05.003</RefTotal>
<RefLink>https://doi.org/10.1053/j.jfas.2006.05.003</RefLink>
</Reference>
<Reference refNo="19">
<RefAuthor>De Benedittis M</RefAuthor>
<RefAuthor>Turco M</RefAuthor>
<RefAuthor>Petruzzi M</RefAuthor>
<RefAuthor>Cortelazzi R</RefAuthor>
<RefTitle>Extra-articular diffuse-type giant cell tumour of the temporomandibular joint</RefTitle>
<RefYear>2013</RefYear>
<RefJournal>Int J Oral Maxillofac Surg</RefJournal>
<RefPage>380-5</RefPage>
<RefTotal>De Benedittis M, Turco M, Petruzzi M, Cortelazzi R. Extra-articular diffuse-type giant cell tumour of the temporomandibular joint. Int J Oral Maxillofac Surg. 2013 Mar;42(3):380-5.
DOI: 10.1016/j.ijom.2012.07.013</RefTotal>
<RefLink>https://doi.org/10.1016/j.ijom.2012.07.013</RefLink>
</Reference>
<Reference refNo="20">
<RefAuthor>Cho JM</RefAuthor>
<RefAuthor>Chang JH</RefAuthor>
<RefAuthor>Kim SH</RefAuthor>
<RefAuthor>Lee KS</RefAuthor>
<RefTitle>Pediatric giant cell tumor of the tendon sheath of the craniocervical junction involving the occipital condyle</RefTitle>
<RefYear>2016</RefYear>
<RefJournal>Childs Nerv Syst</RefJournal>
<RefPage>175-9</RefPage>
<RefTotal>Cho JM, Chang JH, Kim SH, Lee KS. Pediatric giant cell tumor of the tendon sheath of the craniocervical junction involving the occipital condyle. Childs Nerv Syst. 2016 Jan;32(1):175-9.
DOI: 10.1007/s00381-015-2820-5</RefTotal>
<RefLink>https://doi.org/10.1007/s00381-015-2820-5</RefLink>
</Reference>
<Reference refNo="21">
<RefAuthor>Müslüman AM</RefAuthor>
<RefAuthor>Cavuşoğlu H</RefAuthor>
<RefAuthor>Yilmaz A</RefAuthor>
<RefAuthor>Dalkiliç T</RefAuthor>
<RefAuthor>Tanik C</RefAuthor>
<RefAuthor>Aydin Y</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of a lumbar intervertebral facet joint</RefTitle>
<RefYear>2009</RefYear>
<RefJournal>Spine J</RefJournal>
<RefPage>e6-9</RefPage>
<RefTotal>Müslüman AM, Cavuşoğlu H, Yilmaz A, Dalkiliç T, Tanik C, Aydin Y. Pigmented villonodular synovitis of a lumbar intervertebral facet joint. Spine J. 2009 Aug;9(8):e6-9.
DOI: 10.1016/j.spinee.2008.12.010</RefTotal>
<RefLink>https://doi.org/10.1016/j.spinee.2008.12.010</RefLink>
</Reference>
<Reference refNo="22">
<RefAuthor>Lavrador JP</RefAuthor>
<RefAuthor>Oliveira E</RefAuthor>
<RefAuthor>Gil N</RefAuthor>
<RefAuthor>Francisco AF</RefAuthor>
<RefAuthor>Livraghi S</RefAuthor>
<RefTitle>C1-C2 pigmented villonodular synovitis and clear cell carcinoma: unexpected presentation of a rare disease and a review of the literature</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>Eur Spine J</RefJournal>
<RefPage>S465-71</RefPage>
<RefTotal>Lavrador JP, Oliveira E, Gil N, Francisco AF, Livraghi S. C1-C2 pigmented villonodular synovitis and clear cell carcinoma: unexpected presentation of a rare disease and a review of the literature. Eur Spine J. 2015 May;24(Suppl 4):S465-71.
DOI: 10.1007/s00586-014-3396-6</RefTotal>
<RefLink>https://doi.org/10.1007/s00586-014-3396-6</RefLink>
</Reference>
<Reference refNo="23">
<RefAuthor>Dimeco F</RefAuthor>
<RefAuthor>Rizzo P</RefAuthor>
<RefAuthor>Li KW</RefAuthor>
<RefAuthor>Ciceri E</RefAuthor>
<RefAuthor>Casali C</RefAuthor>
<RefAuthor>Pollo B</RefAuthor>
<RefAuthor>Lasio G</RefAuthor>
<RefTitle>Pigment villonodular synovitis of the spine. Case report and review of the literature</RefTitle>
<RefYear>2001</RefYear>
<RefJournal>J Neurosurg Sci</RefJournal>
<RefPage>216-9, discussion 219</RefPage>
<RefTotal>Dimeco F, Rizzo P, Li KW, Ciceri E, Casali C, Pollo B, Lasio G. Pigment villonodular synovitis of the spine. Case report and review of the literature. J Neurosurg Sci. 2001 Dec;45(4):216-9, discussion 219.</RefTotal>
</Reference>
<Reference refNo="24">
<RefAuthor>Oda Y</RefAuthor>
<RefAuthor>Takahira T</RefAuthor>
<RefAuthor>Yokoyama R</RefAuthor>
<RefAuthor>Tsuneyoshi M</RefAuthor>
<RefTitle>Diffuse-type giant cell tumor/pigmented villonodular synovitis arising in the sacrum: malignant form</RefTitle>
<RefYear>2007</RefYear>
<RefJournal>Pathol Int</RefJournal>
<RefPage>627-31</RefPage>
<RefTotal>Oda Y, Takahira T, Yokoyama R, Tsuneyoshi M. Diffuse-type giant cell tumor/pigmented villonodular synovitis arising in the sacrum: malignant form. Pathol Int. 2007 Sep;57(9):627-31.
DOI: 10.1111/j.1440-1827.2007.02150.x</RefTotal>
<RefLink>https://doi.org/10.1111/j.1440-1827.2007.02150.x</RefLink>
</Reference>
<Reference refNo="25">
<RefAuthor>McMaster PE</RefAuthor>
<RefTitle>Pigmented villonodular synovitis with invasion of bone: report of six cases</RefTitle>
<RefYear>1960</RefYear>
<RefJournal>J Bone Joint Surg Am</RefJournal>
<RefPage>1170-83</RefPage>
<RefTotal>McMaster PE. Pigmented villonodular synovitis with invasion of bone: report of six cases. J Bone Joint Surg Am. 1960;42:1170-83. DOI: 10.2106/00004623-196042070-00007</RefTotal>
<RefLink>https://doi.org/10.2106/00004623-196042070-00007</RefLink>
</Reference>
<Reference refNo="26">
<RefAuthor>Nishida Y</RefAuthor>
<RefAuthor>Tsukushi S</RefAuthor>
<RefAuthor>Nakashima H</RefAuthor>
<RefAuthor>Sugiura H</RefAuthor>
<RefAuthor>Yamada Y</RefAuthor>
<RefAuthor>Urakawa H</RefAuthor>
<RefAuthor>Arai E</RefAuthor>
<RefAuthor>Ishiguro N</RefAuthor>
<RefTitle>Osteochondral destruction in pigmented villonodular synovitis during the clinical course</RefTitle>
<RefYear>2012</RefYear>
<RefJournal>J Rheumatol</RefJournal>
<RefPage>345-51</RefPage>
<RefTotal>Nishida Y, Tsukushi S, Nakashima H, Sugiura H, Yamada Y, Urakawa H, Arai E, Ishiguro N. Osteochondral destruction in pigmented villonodular synovitis during the clinical course. J Rheumatol. 2012 Feb;39(2):345-51.
DOI: 10.3899/jrheum.110730</RefTotal>
<RefLink>https://doi.org/10.3899/jrheum.110730</RefLink>
</Reference>
<Reference refNo="27">
<RefAuthor>Taylor R</RefAuthor>
<RefAuthor>Kashima TG</RefAuthor>
<RefAuthor>Knowles H</RefAuthor>
<RefAuthor>Gibbons CL</RefAuthor>
<RefAuthor>Whitwell D</RefAuthor>
<RefAuthor>Athanasou NA</RefAuthor>
<RefTitle>Osteoclast formation and function in pigmented villonodular synovitis</RefTitle>
<RefYear>2011</RefYear>
<RefJournal>J Pathol</RefJournal>
<RefPage>151-6</RefPage>
<RefTotal>Taylor R, Kashima TG, Knowles H, Gibbons CL, Whitwell D, Athanasou NA. Osteoclast formation and function in pigmented villonodular synovitis. J Pathol. 2011 Sep;225(1):151-6.
DOI: 10.1002/path.2937</RefTotal>
<RefLink>https://doi.org/10.1002/path.2937</RefLink>
</Reference>
<Reference refNo="28">
<RefAuthor>Ota T</RefAuthor>
<RefAuthor>Urakawa H</RefAuthor>
<RefAuthor>Kozawa E</RefAuthor>
<RefAuthor>Ikuta K</RefAuthor>
<RefAuthor>Hamada S</RefAuthor>
<RefAuthor>Tsukushi S</RefAuthor>
<RefAuthor>Shimoyama Y</RefAuthor>
<RefAuthor>Ishiguro N</RefAuthor>
<RefAuthor>Nishida Y</RefAuthor>
<RefTitle>Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>Tumour Biol</RefJournal>
<RefPage>5361-7</RefPage>
<RefTotal>Ota T, Urakawa H, Kozawa E, Ikuta K, Hamada S, Tsukushi S, Shimoyama Y, Ishiguro N, Nishida Y. Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. Tumour Biol. 2015 Jul;36(7):5361-7. DOI: 10.1007/s13277-015-3197-5</RefTotal>
<RefLink>https://doi.org/10.1007/s13277-015-3197-5</RefLink>
</Reference>
<Reference refNo="29">
<RefAuthor>Son SM</RefAuthor>
<RefAuthor>Park YS</RefAuthor>
<RefAuthor>Choi CH</RefAuthor>
<RefAuthor>Lee HC</RefAuthor>
<RefAuthor>Lee OJ</RefAuthor>
<RefAuthor>Woo CG</RefAuthor>
<RefTitle>Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report</RefTitle>
<RefYear>2018</RefYear>
<RefJournal>Br J Neurosurg</RefJournal>
<RefPage>688-90</RefPage>
<RefTotal>Son SM, Park YS, Choi CH, Lee HC, Lee OJ, Woo CG. Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. Br J Neurosurg. 2018 Dec;32(6):688-90.
DOI: 10.1080/02688697.2018.1426729</RefTotal>
<RefLink>https://doi.org/10.1080/02688697.2018.1426729</RefLink>
</Reference>
<Reference refNo="30">
<RefAuthor>Trani M</RefAuthor>
<RefAuthor>Zanni M</RefAuthor>
<RefAuthor>Gambelli P</RefAuthor>
<RefTitle>Giant-cell tumor of the tendon sheath in the external auditory canal</RefTitle>
<RefYear>2014</RefYear>
<RefJournal>Ear Nose Throat J</RefJournal>
<RefPage>456-64</RefPage>
<RefTotal>Trani M, Zanni M, Gambelli P. Giant-cell tumor of the tendon sheath in the external auditory canal. Ear Nose Throat J. 2014;93(10-11):456-64.</RefTotal>
</Reference>
<Reference refNo="31">
<RefAuthor>Botez P</RefAuthor>
<RefAuthor>Sirbu PD</RefAuthor>
<RefAuthor>Grierosu C</RefAuthor>
<RefAuthor>Mihailescu D</RefAuthor>
<RefAuthor>Savin L</RefAuthor>
<RefAuthor>Scarlat MM</RefAuthor>
<RefTitle>Adult multifocal pigmented villonodular synovitis--clinical review</RefTitle>
<RefYear>2013</RefYear>
<RefJournal>Int Orthop</RefJournal>
<RefPage>729-33</RefPage>
<RefTotal>Botez P, Sirbu PD, Grierosu C, Mihailescu D, Savin L, Scarlat MM. Adult multifocal pigmented villonodular synovitis--clinical review. Int Orthop. 2013 Apr;37(4):729-33. DOI: 10.1007/s00264-013-1789-5</RefTotal>
<RefLink>https://doi.org/10.1007/s00264-013-1789-5</RefLink>
</Reference>
<Reference refNo="32">
<RefAuthor>Yamashita H</RefAuthor>
<RefAuthor>Endo K</RefAuthor>
<RefAuthor>Enokida M</RefAuthor>
<RefAuthor>Teshima R</RefAuthor>
<RefTitle>Multifocal localized pigmented villonodular synovitis arising separately from intra- and extra-articular knee joint: case report and literature review</RefTitle>
<RefYear>2013</RefYear>
<RefJournal>Eur J Orthop Surg Traumatol</RefJournal>
<RefPage>S273-7</RefPage>
<RefTotal>Yamashita H, Endo K, Enokida M, Teshima R. Multifocal localized pigmented villonodular synovitis arising separately from intra- and extra-articular knee joint: case report and literature review. Eur J Orthop Surg Traumatol. 2013 Nov;23(Suppl 2):S273-7. DOI: 10.1007/s00590-012-1125-6</RefTotal>
<RefLink>https://doi.org/10.1007/s00590-012-1125-6</RefLink>
</Reference>
<Reference refNo="33">
<RefAuthor>Rosario M</RefAuthor>
<RefAuthor>Kim HS</RefAuthor>
<RefAuthor>Yun JY</RefAuthor>
<RefAuthor>Han I</RefAuthor>
<RefTitle>Surveillance for lung metastasis from giant cell tumor of bone</RefTitle>
<RefYear>2017</RefYear>
<RefJournal>J Surg Oncol</RefJournal>
<RefPage>907-13</RefPage>
<RefTotal>Rosario M, Kim HS, Yun JY, Han I. Surveillance for lung metastasis from giant cell tumor of bone. J Surg Oncol. 2017 Dec;116(7):907-13. DOI: 10.1002/jso.24739</RefTotal>
<RefLink>https://doi.org/10.1002/jso.24739</RefLink>
</Reference>
<Reference refNo="34">
<RefAuthor>Righi A</RefAuthor>
<RefAuthor>Gambarotti M</RefAuthor>
<RefAuthor>Sbaraglia M</RefAuthor>
<RefAuthor>Frisoni T</RefAuthor>
<RefAuthor>Donati D</RefAuthor>
<RefAuthor>Vanel D</RefAuthor>
<RefAuthor>Dei Tos AP</RefAuthor>
<RefTitle>Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>Clin Sarcoma Res</RefJournal>
<RefPage>15</RefPage>
<RefTotal>Righi A, Gambarotti M, Sbaraglia M, Frisoni T, Donati D, Vanel D, Dei Tos AP. Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. Clin Sarcoma Res. 2015;5:15. DOI: 10.1186/s13569-015-0030-2</RefTotal>
<RefLink>https://doi.org/10.1186/s13569-015-0030-2</RefLink>
</Reference>
<Reference refNo="35">
<RefAuthor>Osanai T</RefAuthor>
<RefAuthor>Suzuki H</RefAuthor>
<RefAuthor>Hiraga H</RefAuthor>
<RefAuthor>Soma T</RefAuthor>
<RefAuthor>Nojima T</RefAuthor>
<RefTitle>Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases</RefTitle>
<RefYear>2017</RefYear>
<RefJournal>J Orthop Surg (Hong Kong)</RefJournal>
<RefPage>2309499017690323</RefPage>
<RefTotal>Osanai T, Suzuki H, Hiraga H, Soma T, Nojima T. Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases. J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499017690323.
DOI: 10.1177/2309499017690323</RefTotal>
<RefLink>https://doi.org/10.1177/2309499017690323</RefLink>
</Reference>
<Reference refNo="36">
<RefAuthor>Chen EL</RefAuthor>
<RefAuthor>de Castro CM 4th</RefAuthor>
<RefAuthor>Hendzel KD</RefAuthor>
<RefAuthor>Iwaz S</RefAuthor>
<RefAuthor>Kim MA</RefAuthor>
<RefAuthor>Valeshabad AK</RefAuthor>
<RefAuthor>Shokouh-Amiri M</RefAuthor>
<RefAuthor>Xie KL</RefAuthor>
<RefTitle>Histologically benign metastasizing tenosynovial giant cell tumor mimicking metastatic malignancy: A case report and review of literature</RefTitle>
<RefYear>2019</RefYear>
<RefJournal>Radiol Case Rep</RefJournal>
<RefPage>934-40</RefPage>
<RefTotal>Chen EL, de Castro CM 4th, Hendzel KD, Iwaz S, Kim MA, Valeshabad AK, Shokouh-Amiri M, Xie KL. Histologically benign metastasizing tenosynovial giant cell tumor mimicking metastatic malignancy: A case report and review of literature. Radiol Case Rep. 2019 Aug;14(8):934-40. DOI: 10.1016/j.radcr.2019.05.013</RefTotal>
<RefLink>https://doi.org/10.1016/j.radcr.2019.05.013</RefLink>
</Reference>
<Reference refNo="37">
<RefAuthor>Efrima B</RefAuthor>
<RefAuthor>Safran N</RefAuthor>
<RefAuthor>Amar E</RefAuthor>
<RefAuthor>Bachar Avnieli I</RefAuthor>
<RefAuthor>Kollander Y</RefAuthor>
<RefAuthor>Rath E</RefAuthor>
<RefTitle>Simultaneous pigmented villonodular synovitis and synovial chondromatosis of the hip: case report</RefTitle>
<RefYear>2018</RefYear>
<RefJournal>J Hip Preserv Surg</RefJournal>
<RefPage>443-7</RefPage>
<RefTotal>Efrima B, Safran N, Amar E, Bachar Avnieli I, Kollander Y, Rath E. Simultaneous pigmented villonodular synovitis and synovial chondromatosis of the hip: case report. J Hip Preserv Surg. 2018 Dec;5(4):443-7. DOI: 10.1093/jhps/hny034</RefTotal>
<RefLink>https://doi.org/10.1093/jhps/hny034</RefLink>
</Reference>
<Reference refNo="38">
<RefAuthor>Xie GP</RefAuthor>
<RefAuthor>Jiang N</RefAuthor>
<RefAuthor>Liang CX</RefAuthor>
<RefAuthor>Zeng JC</RefAuthor>
<RefAuthor>Chen ZY</RefAuthor>
<RefAuthor>Xu Q</RefAuthor>
<RefAuthor>Qi RZ</RefAuthor>
<RefAuthor>Chen YR</RefAuthor>
<RefAuthor>Yu B</RefAuthor>
<RefTitle>Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>PLoS One</RefJournal>
<RefPage>e0121451</RefPage>
<RefTotal>Xie GP, Jiang N, Liang CX, Zeng JC, Chen ZY, Xu Q, Qi RZ, Chen YR, Yu B. Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases. PLoS One. 2015;10(3):e0121451. DOI: 10.1371/journal.pone.0121451</RefTotal>
<RefLink>https://doi.org/10.1371/journal.pone.0121451</RefLink>
</Reference>
<Reference refNo="39">
<RefAuthor>Bruns J</RefAuthor>
<RefAuthor>Schubert T</RefAuthor>
<RefAuthor>Eggers-Stroeder G</RefAuthor>
<RefTitle>Pigmented villonodular synovitis in children. A case report</RefTitle>
<RefYear>1993</RefYear>
<RefJournal>Arch Orthop Trauma Surg</RefJournal>
<RefPage>148-51</RefPage>
<RefTotal>Bruns J, Schubert T, Eggers-Stroeder G. Pigmented villonodular synovitis in children. A case report. Arch Orthop Trauma Surg. 1993;112(3):148-51. DOI: 10.1007/BF00449993</RefTotal>
<RefLink>https://doi.org/10.1007/BF00449993</RefLink>
</Reference>
<Reference refNo="40">
<RefAuthor>Baroni E</RefAuthor>
<RefAuthor>Russo BD</RefAuthor>
<RefAuthor>Masquijo JJ</RefAuthor>
<RefAuthor>Bassini O</RefAuthor>
<RefAuthor>Miscione H</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of the knee in skeletally immature patients</RefTitle>
<RefYear>2010</RefYear>
<RefJournal>J Child Orthop</RefJournal>
<RefPage>123-7</RefPage>
<RefTotal>Baroni E, Russo BD, Masquijo JJ, Bassini O, Miscione H. Pigmented villonodular synovitis of the knee in skeletally immature patients. J Child Orthop. 2010 Apr;4(2):123-7.
DOI: 10.1007/s11832-009-0236-z</RefTotal>
<RefLink>https://doi.org/10.1007/s11832-009-0236-z</RefLink>
</Reference>
<Reference refNo="41">
<RefAuthor>Sistla R</RefAuthor>
<RefAuthor>Vidyasagar JVS</RefAuthor>
<RefAuthor>Afroz T</RefAuthor>
<RefTitle>Malignant Pigmented Villonodular Synovitis – A Rare Entity</RefTitle>
<RefYear>2014</RefYear>
<RefJournal>J Orthop Case Rep</RefJournal>
<RefPage>9-11</RefPage>
<RefTotal>Sistla R, Vidyasagar JVS, Afroz T. Malignant Pigmented Villonodular Synovitis – A Rare Entity. J Orthop Case Rep. 2014;4(4):9-11. DOI: 10.13107/jocr.2250-0685.214</RefTotal>
<RefLink>https://doi.org/10.13107/jocr.2250-0685.214</RefLink>
</Reference>
<Reference refNo="42">
<RefAuthor>Imakiire N</RefAuthor>
<RefAuthor>Fujino T</RefAuthor>
<RefAuthor>Morii T</RefAuthor>
<RefAuthor>Honya K</RefAuthor>
<RefAuthor>Mochizuki K</RefAuthor>
<RefAuthor>Satomi K</RefAuthor>
<RefAuthor>Fujioka Y</RefAuthor>
<RefTitle>Malignant pigmented villonodular synovitis in the knee – report of a case with rapid clinical progression</RefTitle>
<RefYear>2011</RefYear>
<RefJournal>Open Orthop J</RefJournal>
<RefPage>13-6</RefPage>
<RefTotal>Imakiire N, Fujino T, Morii T, Honya K, Mochizuki K, Satomi K, Fujioka Y. Malignant pigmented villonodular synovitis in the knee – report of a case with rapid clinical progression. Open Orthop J. 2011 Jan;5:13-6. DOI: 10.2174/1874325001105010013</RefTotal>
<RefLink>https://doi.org/10.2174/1874325001105010013</RefLink>
</Reference>
<Reference refNo="43">
<RefAuthor>Bruns J</RefAuthor>
<RefAuthor>Ewerbeck V</RefAuthor>
<RefAuthor>Dominkus M</RefAuthor>
<RefAuthor>Windhager R</RefAuthor>
<RefAuthor>Hassenpflug J</RefAuthor>
<RefAuthor>Windhagen H</RefAuthor>
<RefAuthor>Hovy L</RefAuthor>
<RefAuthor>Loehr J</RefAuthor>
<RefAuthor>Krauspe R</RefAuthor>
<RefAuthor>Duerr HR</RefAuthor>
<RefTitle>Pigmented villo-nodular synovitis and giant-cell tumor of tendon sheaths: a binational retrospective study</RefTitle>
<RefYear>2013</RefYear>
<RefJournal>Arch Orthop Trauma Surg</RefJournal>
<RefPage>1047-53</RefPage>
<RefTotal>Bruns J, Ewerbeck V, Dominkus M, Windhager R, Hassenpflug J, Windhagen H, Hovy L, Loehr J, Krauspe R, Duerr HR. Pigmented villo-nodular synovitis and giant-cell tumor of tendon sheaths: a binational retrospective study. Arch Orthop Trauma Surg. 2013 Aug;133(8):1047-53. DOI: 10.1007/s00402-013-1770-1</RefTotal>
<RefLink>https://doi.org/10.1007/s00402-013-1770-1</RefLink>
</Reference>
<Reference refNo="44">
<RefAuthor>Campanacci M</RefAuthor>
<RefAuthor>Pagani PA</RefAuthor>
<RefAuthor>Musiani M</RefAuthor>
<RefAuthor>Libri R</RefAuthor>
<RefTitle>Sinovite, tenosinovite, borsite villonodulare e nodulare pigmentosa (studio di 75 osservazioni)</RefTitle>
<RefYear>1975</RefYear>
<RefJournal>Chir Organi Mov</RefJournal>
<RefPage>675-86</RefPage>
<RefTotal>Campanacci M, Pagani PA, Musiani M, Libri R. Sinovite, tenosinovite, borsite villonodulare e nodulare pigmentosa (studio di 75 osservazioni) [Pigmented, villonodular synovitis, tenosynovitis and bursitis (study of 75 cases)]. Chir Organi Mov. 1975;61(6):675-86.</RefTotal>
</Reference>
<Reference refNo="45">
<RefAuthor>Solomou A</RefAuthor>
<RefAuthor>Kraniotis P</RefAuthor>
<RefTitle>Giant cell tumor of the tendon seath of the tendinous insertion in pes anserinus</RefTitle>
<RefYear>2017</RefYear>
<RefJournal>Radiol Case Rep</RefJournal>
<RefPage>353-6</RefPage>
<RefTotal>Solomou A, Kraniotis P. Giant cell tumor of the tendon seath of the tendinous insertion in pes anserinus. Radiol Case Rep. 2017 Jun;12(2):353-6. DOI: 10.1016/j.radcr.2017.02.001</RefTotal>
<RefLink>https://doi.org/10.1016/j.radcr.2017.02.001</RefLink>
</Reference>
<Reference refNo="46">
<RefAuthor>Zhao H</RefAuthor>
<RefAuthor>Maheshwari AV</RefAuthor>
<RefAuthor>Kumar D</RefAuthor>
<RefAuthor>Malawer MM</RefAuthor>
<RefTitle>Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature</RefTitle>
<RefYear>2011</RefYear>
<RefJournal>Case Rep Med</RefJournal>
<RefPage>491470</RefPage>
<RefTotal>Zhao H, Maheshwari AV, Kumar D, Malawer MM. Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. Case Rep Med. 2011;2011:491470. DOI: 10.1155/2011/491470</RefTotal>
<RefLink>https://doi.org/10.1155/2011/491470</RefLink>
</Reference>
<Reference refNo="47">
<RefAuthor>Maheshwari AV</RefAuthor>
<RefAuthor>Muro-Cacho CA</RefAuthor>
<RefAuthor>Pitcher JD Jr</RefAuthor>
<RefTitle>Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature</RefTitle>
<RefYear>2007</RefYear>
<RefJournal>Knee</RefJournal>
<RefPage>402-7</RefPage>
<RefTotal>Maheshwari AV, Muro-Cacho CA, Pitcher JD Jr. Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature. Knee. 2007 Oct;14(5):402-7. DOI: 10.1016/j.knee.2007.06.004</RefTotal>
<RefLink>https://doi.org/10.1016/j.knee.2007.06.004</RefLink>
</Reference>
<Reference refNo="48">
<RefAuthor>Katz DS</RefAuthor>
<RefAuthor>Levinsohn EM</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of the sequestered suprapatellar bursa</RefTitle>
<RefYear>1994</RefYear>
<RefJournal>Clin Orthop Relat Res</RefJournal>
<RefPage>204-8</RefPage>
<RefTotal>Katz DS, Levinsohn EM. Pigmented villonodular synovitis of the sequestered suprapatellar bursa. Clin Orthop Relat Res. 1994 Sep;(306):204-8.</RefTotal>
</Reference>
<Reference refNo="49">
<RefAuthor>Konrath GA</RefAuthor>
<RefAuthor>Nahigian K</RefAuthor>
<RefAuthor>Kolowich P</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of the subacromial bursa</RefTitle>
<RefYear>1997</RefYear>
<RefJournal>J Shoulder Elbow Surg</RefJournal>
<RefPage>400-4</RefPage>
<RefTotal>Konrath GA, Nahigian K, Kolowich P. Pigmented villonodular synovitis of the subacromial bursa. J Shoulder Elbow Surg. 1997;6(4):400-4. DOI: 10.1016/s1058-2746(97)90010-0</RefTotal>
<RefLink>https://doi.org/10.1016/s1058-2746(97)90010-0</RefLink>
</Reference>
<Reference refNo="50">
<RefAuthor>Cho CH</RefAuthor>
<RefAuthor>Sohn SW</RefAuthor>
<RefAuthor>Song KS</RefAuthor>
<RefAuthor>Kang CH</RefAuthor>
<RefAuthor>Min BW</RefAuthor>
<RefAuthor>Bae KC</RefAuthor>
<RefAuthor>Lee SM</RefAuthor>
<RefTitle>Extra-articular pigmented villonodular synovitis of the subacromial space</RefTitle>
<RefYear>2008</RefYear>
<RefJournal>Orthopedics</RefJournal>
<RefPage></RefPage>
<RefTotal>Cho CH, Sohn SW, Song KS, Kang CH, Min BW, Bae KC, Lee SM. Extra-articular pigmented villonodular synovitis of the subacromial space. Orthopedics. 2008 Dec;31(12). DOI: 10.3928/01477447-20081201-04</RefTotal>
<RefLink>https://doi.org/10.3928/01477447-20081201-04</RefLink>
</Reference>
<Reference refNo="51">
<RefAuthor>Gokhale N</RefAuthor>
<RefAuthor>Purohit S</RefAuthor>
<RefAuthor>Bhosale PB</RefAuthor>
<RefTitle>Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst</RefTitle>
<RefYear>2015</RefYear>
<RefJournal>J Orthop Case Rep</RefJournal>
<RefPage>63-5</RefPage>
<RefTotal>Gokhale N, Purohit S, Bhosale PB. Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst. J Orthop Case Rep. 2015;5(3):63-5. DOI: 10.13107/jocr.2250-0685.311</RefTotal>
<RefLink>https://doi.org/10.13107/jocr.2250-0685.311</RefLink>
</Reference>
<Reference refNo="52">
<RefAuthor>Weisser JR</RefAuthor>
<RefAuthor>Robinson DW</RefAuthor>
<RefTitle>Pigmented villonodular synovitis of iliopectineal bursa; a case report</RefTitle>
<RefYear>1951</RefYear>
<RefJournal>J Bone Joint Surg Am</RefJournal>
<RefPage>988-92</RefPage>
<RefTotal>Weisser JR, Robinson DW. Pigmented villonodular synovitis of iliopectineal bursa; a case report. J Bone Joint Surg Am. 1951 Oct;33-A(4):988-92.</RefTotal>
</Reference>
<Reference refNo="53">
<RefAuthor>Cheng XG</RefAuthor>
<RefAuthor>You YH</RefAuthor>
<RefAuthor>Liu W</RefAuthor>
<RefAuthor>Zhao T</RefAuthor>
<RefAuthor>Qu H</RefAuthor>
<RefTitle>MRI features of pigmented villonodular synovitis (PVNS)</RefTitle>
<RefYear>2004</RefYear>
<RefJournal>Clin Rheumatol</RefJournal>
<RefPage>31-4</RefPage>
<RefTotal>Cheng XG, You YH, Liu W, Zhao T, Qu H. MRI features of pigmented villonodular synovitis (PVNS). Clin Rheumatol. 2004 Feb;23(1):31-4. DOI: 10.1007/s10067-003-0827-x</RefTotal>
<RefLink>https://doi.org/10.1007/s10067-003-0827-x</RefLink>
</Reference>
<Reference refNo="54">
<RefAuthor>Barile A</RefAuthor>
<RefAuthor>Sabatini M</RefAuthor>
<RefAuthor>Iannessi F</RefAuthor>
<RefAuthor>Di Cesare E</RefAuthor>
<RefAuthor>Splendiani A</RefAuthor>
<RefAuthor>Calvisi V</RefAuthor>
<RefAuthor>Masciocchi C</RefAuthor>
<RefTitle>Pigmented villonodular synovitis (PVNS) of the knee joint: magnetic resonance imaging (MRI) using standard and dynamic paramagnetic contrast media. Report of 52 cases surgically and histologically controlled</RefTitle>
<RefYear>2004</RefYear>
<RefJournal>Radiol Med</RefJournal>
<RefPage>356-66</RefPage>
<RefTotal>Barile A, Sabatini M, Iannessi F, Di Cesare E, Splendiani A, Calvisi V, Masciocchi C. Pigmented villonodular synovitis (PVNS) of the knee joint: magnetic resonance imaging (MRI) using standard and dynamic paramagnetic contrast media. Report of 52 cases surgically and histologically controlled. Radiol Med. 2004 Apr;107(4):356-66.</RefTotal>
</Reference>
<Reference refNo="55">
<RefAuthor>Murphey MD</RefAuthor>
<RefAuthor>Rhee JH</RefAuthor>
<RefAuthor>Lewis RB</RefAuthor>
<RefAuthor>Fanburg-Smith JC</RefAuthor>
<RefAuthor>Flemming DJ</RefAuthor>
<RefAuthor>Walker EA</RefAuthor>
<RefTitle>Pigmented villonodular synovitis: radiologic-pathologic correlation</RefTitle>
<RefYear>2008</RefYear>
<RefJournal>Radiographics</RefJournal>
<RefPage>1493-518</RefPage>
<RefTotal>Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics. 2008;28(5):1493-518. DOI: 10.1148/rg.285085134</RefTotal>
<RefLink>https://doi.org/10.1148/rg.285085134</RefLink>
</Reference>
<Reference refNo="56">
<RefAuthor>van der Heijden L</RefAuthor>
<RefAuthor>Gibbons CL</RefAuthor>
<RefAuthor>Dijkstra PD</RefAuthor>
<RefAuthor>Kroep JR</RefAuthor>
<RefAuthor>van Rijswijk CS</RefAuthor>
<RefAuthor>Nout RA</RefAuthor>
<RefAuthor>Bradley KM</RefAuthor>
<RefAuthor>Athanasou NA</RefAuthor>
<RefAuthor>Hogendoorn PC</RefAuthor>
<RefAuthor>van de Sande MA</RefAuthor>
<RefTitle>The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis)</RefTitle>
<RefYear>2012</RefYear>
<RefJournal>J Bone Joint Surg Br</RefJournal>
<RefPage>882-8</RefPage>
<RefTotal>van der Heijden L, Gibbons CL, Dijkstra PD, Kroep JR, van Rijswijk CS, Nout RA, Bradley KM, Athanasou NA, Hogendoorn PC, van de Sande MA. The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). J Bone Joint Surg Br. 2012 Jul;94(7):882-8. DOI: 10.1302/0301-620X.94B7.28927</RefTotal>
<RefLink>https://doi.org/10.1302/0301-620X.94B7.28927</RefLink>
</Reference>
<Reference refNo="57">
<RefAuthor>Mastboom MJL</RefAuthor>
<RefAuthor>Palmerini E</RefAuthor>
<RefAuthor>Verspoor FGM</RefAuthor>
<RefAuthor>Rueten-Budde AJ</RefAuthor>
<RefAuthor>Stacchiotti S</RefAuthor>
<RefAuthor>Staals EL</RefAuthor>
<RefAuthor>Schaap GR</RefAuthor>
<RefAuthor>Jutte PC</RefAuthor>
<RefAuthor>Aston W</RefAuthor>
<RefAuthor>Gelderblom H</RefAuthor>
<RefAuthor>Leithner A</RefAuthor>
<RefAuthor>Dammerer D</RefAuthor>
<RefAuthor>Takeuchi A</RefAuthor>
<RefAuthor>Thio Q</RefAuthor>
<RefAuthor>Niu X</RefAuthor>
<RefAuthor>Wunder JS</RefAuthor>
<RefAuthor> TGCT Study Groupvan de Sande MAJ</RefAuthor>
<RefTitle>Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study</RefTitle>
<RefYear>2019</RefYear>
<RefJournal>Lancet Oncol</RefJournal>
<RefPage>877-86</RefPage>
<RefTotal>Mastboom MJL, Palmerini E, Verspoor FGM, Rueten-Budde AJ, Stacchiotti S, Staals EL, Schaap GR, Jutte PC, Aston W, Gelderblom H, Leithner A, Dammerer D, Takeuchi A, Thio Q, Niu X, Wunder JS; TGCT Study Groupvan de Sande MAJ. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study. Lancet Oncol. 2019 Jun;20(6):877-86.
DOI: 10.1016/S1470-2045(19)30100-7</RefTotal>
<RefLink>https://doi.org/10.1016/S1470-2045(19)30100-7</RefLink>
</Reference>
<Reference refNo="58">
<RefAuthor>Mastboom MJL</RefAuthor>
<RefAuthor>Staals EL</RefAuthor>
<RefAuthor>Verspoor FGM</RefAuthor>
<RefAuthor>Rueten-Budde AJ</RefAuthor>
<RefAuthor>Stacchiotti S</RefAuthor>
<RefAuthor>Palmerini E</RefAuthor>
<RefAuthor>Schaap GR</RefAuthor>
<RefAuthor>Jutte PC</RefAuthor>
<RefAuthor>Aston W</RefAuthor>
<RefAuthor>Leithner A</RefAuthor>
<RefAuthor>Dammerer D</RefAuthor>
<RefAuthor>Takeuchi A</RefAuthor>
<RefAuthor>Thio Q</RefAuthor>
<RefAuthor>Niu X</RefAuthor>
<RefAuthor>Wunder JS</RefAuthor>
<RefAuthor>van de Sande MAJ</RefAuthor>
<RefAuthor> Tenosynovial Giant Cell Tumors (TGCT) Study Group</RefAuthor>
<RefTitle>Surgical Treatment of Localized-Type Tenosynovial Giant Cell Tumors of Large Joints: A Study Based on a Multicenter-Pooled Database of 31 International Sarcoma Centers</RefTitle>
<RefYear>2019</RefYear>
<RefJournal>J Bone Joint Surg Am</RefJournal>
<RefPage>1309-18</RefPage>
<RefTotal>Mastboom MJL, Staals EL, Verspoor FGM, Rueten-Budde AJ, Stacchiotti S, Palmerini E, Schaap GR, Jutte PC, Aston W, Leithner A, Dammerer D, Takeuchi A, Thio Q, Niu X, Wunder JS, van de Sande MAJ; Tenosynovial Giant Cell Tumors (TGCT) Study Group. Surgical Treatment of Localized-Type Tenosynovial Giant Cell Tumors of Large Joints: A Study Based on a Multicenter-Pooled Database of 31 International Sarcoma Centers. J Bone Joint Surg Am. 2019 Jul;101(14):1309-18. DOI: 10.2106/JBJS.18.01147</RefTotal>
<RefLink>https://doi.org/10.2106/JBJS.18.01147</RefLink>
</Reference>
<Reference refNo="59">
<RefAuthor>Horoschak M</RefAuthor>
<RefAuthor>Tran PT</RefAuthor>
<RefAuthor>Bachireddy P</RefAuthor>
<RefAuthor>West RB</RefAuthor>
<RefAuthor>Mohler D</RefAuthor>
<RefAuthor>Beaulieu CF</RefAuthor>
<RefAuthor>Kapp DS</RefAuthor>
<RefAuthor>Donaldson SS</RefAuthor>
<RefTitle>External beam radiation therapy enhances local control in pigmented villonodular synovitis</RefTitle>
<RefYear>2009</RefYear>
<RefJournal>Int J Radiat Oncol Biol Phys</RefJournal>
<RefPage>183-7</RefPage>
<RefTotal>Horoschak M, Tran PT, Bachireddy P, West RB, Mohler D, Beaulieu CF, Kapp DS, Donaldson SS. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 2009 Sep;75(1):183-7. DOI: 10.1016/j.ijrobp.2008.10.058</RefTotal>
<RefLink>https://doi.org/10.1016/j.ijrobp.2008.10.058</RefLink>
</Reference>
<Reference refNo="60">
<RefAuthor>Mendenhall WM</RefAuthor>
<RefAuthor>Mendenhall CM</RefAuthor>
<RefAuthor>Reith JD</RefAuthor>
<RefAuthor>Scarborough MT</RefAuthor>
<RefAuthor>Gibbs CP</RefAuthor>
<RefAuthor>Mendenhall NP</RefAuthor>
<RefTitle>Pigmented villonodular synovitis</RefTitle>
<RefYear>2006</RefYear>
<RefJournal>Am J Clin Oncol</RefJournal>
<RefPage>548-50</RefPage>
<RefTotal>Mendenhall WM, Mendenhall CM, Reith JD, Scarborough MT, Gibbs CP, Mendenhall NP. Pigmented villonodular synovitis. Am J Clin Oncol. 2006 Dec;29(6):548-50.
DOI: 10.1097/01.coc.0000239142.48188.f6</RefTotal>
<RefLink>https://doi.org/10.1097/01.coc.0000239142.48188.f6</RefLink>
</Reference>
</References>
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<Caption><Pgraph><Mark1>Figure 1: Proton-weighted coronal plane showing an enlarged bursa trochanterica on the left side</Mark1></Pgraph></Caption>
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<Caption><Pgraph><Mark1>Figure 2: Proton-weighted transversal plane exhibiting the enlargd bursa filled with fluid and soft-tissue protruded into the bursa trochanterica (marked by an arrow)</Mark1></Pgraph></Caption>
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<Caption><Pgraph><Mark1>Figure 3: T-1 weighted fat-suppressed transversal plane with contrast medium exhibiting the enlargd bursa filled with fluid and soft-tissue protruded into the bursa trochanterica and surrounded by contrast medium (marked by the arrows)</Mark1></Pgraph></Caption>
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<Caption><Pgraph><Mark1>Figure 4: T-1 native coronal plane exhibiting the enlarged bursa trochanteria containing PVNS-soft-tissue</Mark1></Pgraph></Caption>
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