dgkh000406 10.3205/dgkh000406 urn:nbn:de:0183-dgkh0004069 Letter to the Editor Eine Empfehlung für PHTALOX® zur Vorbeugung der Infektion und des Fortschreitens von COVID-19: ein Jahr zusammengefasstes Update wissenschaftlicher Ansätze da Fonseca Orcina da Fonseca Orcina Bernardo B

University of Sao Paulo, Bauru School of Dentistry, Department of Surgery, Stomatology, Pathology and Radiology Bauru, Brazil

author Reia Reia Verônica Caroline Brito VCB

University of Sao Paulo, Bauru School of Dentistry, Department of Surgery, Stomatology, Pathology and Radiology Bauru, Brazil

author Simão Simão Andréa Name Colado ANC

State University of Londrina, Londrina, Brazil

author Lonni Lonni Audrey Alesandra Stinghen Garcia AASG

State University of Londrina, Londrina, Brazil

author Fernandes Fernandes Thais Maria Freire TMF

Department of Orthodontics, University of North Paraná (UNOPAR), Londrina, Brazil

author Poleti Poleti Marcelo Lupion ML

Federal Institute of Parana, Londrina, Brazil

author Vilhena Vilhena Fabiano Vieira FV

TRIALS – Oral Health & Technologies, Bauru, Brazil

author da Silva Santos da Silva Santos Paulo Sérgio PS DDS, PhD

Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9–75, Bauru, SP, 17012-901, Brazil, Phone: +55 14 99670-0921University of Sao Paulo, Bauru School of Dentistry, Department of Surgery, Stomatology, Pathology and Radiology Bauru, Brazil

paulosss@fob.usp.br author German Medical Science GMS Publishing House

Düsseldorf

610 20220131 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). 2196-5226 17 GMS Hygiene and Infection Control GMS Hyg Infect Control 03 Letter to the editorDear editor,The role of the oral cavity in the genesis, progression, and dissemination of COVID-19 has been revealed by breakthroughs in SARS-CoV-2 research . As a result, in 2020, our research group presented a recommendation for PHTALOX® mouthwash for reducing COVID-19 infection and progression . On this occasion, we revealed the first clinical findings in patients with COVID-19 who utilized PHTALOX®, an antiviral phthalocyanine derivative (APD), in a gargle/rinse mouthwash protocol . We updated the information with new insights on the usage of the APD method since PHTALOX® was indicated against SARS-CoV-2 (Table 1 ).Hence, combined with immunizations, the activity of products containing PHTALOX® may help prevent patients from transmitting SARS-CoV-2 and thus help prevent others from contracting COVID-19. Following this logic, additional findings from our study group underscore the positive impact of APD. In epidemiological research, the usage of products containing APD reduced virus dissemination and COVID-19 symptoms . In a population-based study with a sample that used APD, a reduction (p<0.05) in the incidence of COVID-19 was observed compared to a control population without APD exposure . Thus, while vaccines are the most important tool in combating the COVID-19 pandemic, they are not 100% effective in those vaccinated, and even after the initial dose, antibody production takes several days to mature, followed by reinforcement with additional doses , at which point gargle-and-rinse solutions may be an effective option.As previously indicated, we emphasize how important it is for scientists and governments to evaluate the impact of APD policies in hospitals and the general community on SARS-COV-2 VL, hence reducing the virus's transmission and severity of COVID-19. NotesCompeting interestsAll authors submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr. Vilhena reports personal fees from TRIALS Inc. while conducting the study. In addition, Dr. Vilhena has a patent pending. Dr. da Silva Santos reports grants from CNPq process nº. 309525/2018-7. The other authors claim no conflicts of interest.AcknowledgmentsThis study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil (Finance Code 001).ORCID-ID of the AuthorsBernardo da Fonseca Orcina:https://orcid.org/0000-0003-3367-483XVerônica Caroline Brito Reia:https://orcid.org/0000-0003-1352-5474Andrea Name Colado Simão:https://orcid.org/0000-0002-2073-6782Audrey Alesandra Stinghen Garcia Lonni: https://orcid.org/0000-0001-6498-2806Thais Maria Freire Fernandes:https://orcid.org/ 0000-0002-4368-8568Marcelo Lupion Poleti:https://orcid.org/0000-0003-1904-5762Fabiano Vieira Vilhena:https://orcid.org/0000-0003-3840-3633 Paulo Sérgio da Silva Santos:https://orcid.org/0000-0002-0674-3759 Huang N Pérez P Kato T Mikami Y Okuda K Gilmore RC Conde CD Gasmi B Stein S Beach M Pelayo E Maldonado JO Lafont BA Jang SI Nasir N Padilla RJ Murrah VA Maile R Lovell W Wallet SM Bowman NM Meinig SL Wolfgang MC Choudhury SN Novotny M Aevermann BD Scheuermann RH Cannon G Anderson CW Lee RE Marchesan JT Bush M Freire M Kimple AJ Herr DL Rabin J Grazioli A Das S French BN Pranzatelli T Chiorini JA Kleiner DE Pittaluga S Hewitt SM Burbelo PD Chertow D NIH COVID-19 Autopsy Consortium HCA Oral and Craniofacial Biological NetworkFrank K Lee J Boucher RC Teichmann SA Warner BM Byrd KM SARS-CoV-2 infection of the oral cavity and saliva 2021 Nat Med 892-903 Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang SI, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW, Lee RE, Marchesan JT, Bush M, Freire M, Kimple AJ, Herr DL, Rabin J, Grazioli A, Das S, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt SM, Burbelo PD, Chertow D; NIH COVID-19 Autopsy Consortium; HCA Oral and Craniofacial Biological NetworkFrank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med. 2021 05;27(5):892-903. DOI: 10.1038/s41591-021-01296-8 https://doi.org/10.1038/s41591-021-01296-8 da Silva Santos PS da Fonseca Orcina B da Costa Alves LM Cardoso de Oliveira R Mariana Schutzer Ragghianti Zangrando M Vieira Vilhena F A Recommendation of PHTALOX® Mouthwash for Preventing Infection and Progression of COVID-19 2020 Acta Scient Dent Sci 111-2 da Silva Santos PS, da Fonseca Orcina B, da Costa Alves LM, Cardoso de Oliveira R, Mariana Schutzer Ragghianti Zangrando M, Vieira Vilhena F. A Recommendation of PHTALOX® Mouthwash for Preventing Infection and Progression of COVID-19. Acta Scient Dent Sci. 2020;4(12):111-2. DOI: 10.31080/ASDS.2020.04.0991 https://doi.org/10.31080/ASDS.2020.04.0991 Vilhena FV Brito Reia VC da Fonseca Orcina B Santos CA Zangrando M Cardoso de Oliveira R da Silva Santos PS The use of antiviral Phthalocyanine mouthwash as a preventive measure against COVID-19 2021 GMS Hyg Infect Control Doc24 Vilhena FV, Brito Reia VC, da Fonseca Orcina B, Santos CA, Zangrando M, Cardoso de Oliveira R, da Silva Santos PS. The use of antiviral Phthalocyanine mouthwash as a preventive measure against COVID-19. GMS Hyg Infect Control. 2021 Jul 9;16:Doc24. DOI: 10.3205/dgkh000395 https://doi.org/10.3205/dgkh000395 Santos C da Fonseca Orcina B Brito Reia VC Ribeiro LG Grotto RMT Prudenciatti A de Moraes LN Ragghianti Zangrando M Vilhena FV da Silva Santos PS Virucidal Activity of the Antiseptic Mouthwash and Dental Gel Containing Anionic Phthalocyanine Derivative: In vitro Study 2021 Clin Cosmet Investig Dent 269-74 Santos C, da Fonseca Orcina B, Brito Reia VC, Ribeiro LG, Grotto RMT, Prudenciatti A, de Moraes LN, Ragghianti Zangrando M, Vilhena FV, da Silva Santos PS. Virucidal Activity of the Antiseptic Mouthwash and Dental Gel Containing Anionic Phthalocyanine Derivative: In vitro Study. Clin Cosmet Investig Dent. 2021;13:269-74. DOI: 10.2147/CCIDE.S315419 https://doi.org/10.2147/CCIDE.S315419 da Fonseca Orcina B Vilhena FV Cardoso de Oliveira R Marques da Costa Alves L Araki K Toma SH Ragghianti Zangrando MS da Silva Santos PS A Phthalocyanine Derivate Mouthwash to Gargling/Rinsing as an Option to Reduce Clinical Symptoms of COVID-19: Case Series 2021 Clin Cosmet Investig Dent 47-50 da Fonseca Orcina B, Vilhena FV, Cardoso de Oliveira R, Marques da Costa Alves L, Araki K, Toma SH, Ragghianti Zangrando MS, da Silva Santos PS. A Phthalocyanine Derivate Mouthwash to Gargling/Rinsing as an Option to Reduce Clinical Symptoms of COVID-19: Case Series. Clin Cosmet Investig Dent. 2021;13:47-50. 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DOI: 10.1038/s41598-021-99013-5 https://doi.org/10.1038/s41598-021-99013-5 Reia VCB Bastos RS Vilhena FV Honório HM Alves LMC Frazão P Santos PSS Population-based virucidal phthalocyanine gargle/rinse protocol to reduce the risk of coronavirus disease-2019: a community trial [Preprint] 2021 Res Sq Reia VCB, Bastos RS, Vilhena FV, Honório HM, Alves LMC, Frazão P, Santos PSS. Population-based virucidal phthalocyanine gargle/rinse protocol to reduce the risk of coronavirus disease-2019: a community trial [Preprint]. Res Sq. 2021. DOI: 10.21203/rs.3.rs-1065834/v1 https://doi.org/10.21203/rs.3.rs-1065834/v1 Poleti ML Gregório D Bistaffa AG Vilhena FV Simão AN Mori MT Stadtlober NP Lozovoy MA da Silva Santos PS Tatibana BT Fernandes TM Toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative for the intraoral reduction of viral load of SARS-CoV-2: a pilot study. [Preprint] 2021 Res Sq Poleti ML, Gregório D, Bistaffa AG, Vilhena FV, Simão AN, Mori MT, Stadtlober NP, Lozovoy MA, da Silva Santos PS, Tatibana BT, Fernandes TM. Toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative for the intraoral reduction of viral load of SARS-CoV-2: a pilot study. Res Sq [Preprint]. 2021. DOI: 10.21203/rs.3.rs-690819/v1. https://doi.org/10.21203/rs.3.rs-690819/v1. 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DOI: 10.1056/NEJMc2101667 https://doi.org/10.1056/NEJMc2101667 11

Table 1: Summarized results for the use of PHTALOX® against COVID-19

1 0 0 0