Risk assessment of mixed and displacement ventilation (LAF) during orthopedic and trauma surgery on COVID-19 patients with increased release of infectious aerosols

dgkh000342 10.3205/dgkh000342 urn:nbn:de:0183-dgkh0003420 Letter to the Editor Risk assessment of mixed and displacement ventilation (LAF) during orthopedic and trauma surgery on COVID-19 patients with increased release of infectious aerosols Risikobewertung raumlufttechnischer Anlagen (RLTA) mit Mischlüftung bzw. Verdrängungsströmung (LAF) bei Operationen mit an COVID-19 Erkrankten bei erhöhter Freisetzung infektiöser Aerosole Kramer Kramer Axel A Prof. Dr. med.

Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 49 a, 17489 Greifswald, Germany, Phone: +49 3834 864820Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Germany

kramer@uni-greifswald.de author Külpmann Külpmann Rüdiger R

Lucerne University of Applied Sciences and Arts, E & A, Horw, Switzerland

author Brunner Brunner Arnold A

Brunner Consulting, Pfaeffikon ZH, Switzerland

author Müller Müller Michael M

Center for Musculoskeletal Surgery, Charité – University Medicine Berlin, Germany

author Wassilew Wassilew Georgi G

Clinic and Ambulance for Orthopedic and Orthopedic Surgery, University Medicine Greifswald, Germany

author German Medical Science GMS Publishing House

Düsseldorf

610 Displacement ventilation laminar air flow mixed ventilation no ventilation negative pressure SARS-CoV-2 spread 20200514 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). 2196-5226 15 GMS Hygiene and Infection Control GMS Hyg Infect Control 07 LetterPotential transmission routesThe SARS-CoV-2 virus is primarily released from the respiratory tract as an aerosol, which can be increasingly released through intubation, bronchoscopy, or rhinoscopy, for example , . Small particles can remain suspended in the air for several hours . It is not known how long the corona virus persists in room air. On inanimate surfaces such as metal, glass, or plastic, human coronaviruses, e.g., Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus, or endemic human coronaviruses (HCoV) can persist for up to 9 days . SARS-CoV-2 is also detectable in the blood, with a prevalence of 15% . Thus, for everyone in the operating room (OR), various infection risks exist.The patient’s head area can be covered during surgery, provided that the intervention does not target the head area. In contrast, during larger operations in orthopedics and trauma surgery, not only blood, bone, or tissue particles are distributed in the OR, but also blood dust created by a surgical hammer, for example, behave similarly to aerosols.The role of vapors from electrocautery has not been established. Therefore, it should be avoided or an additional smoke extraction system should be used.Basic hygiene measuresAccordingly, all precautions must be taken to protect the personnel in the operating room, i.e., protective clothing, FFP3 mask, safety glasses, and if necessary foot protection or waterproof boots. After the finalization of the surgical operation, all surfaces in the OR must be disinfected with a virucidal disinfectant such as an oxygen releaser or hypochlorite. If a device for room disinfection with nebulizing hydrogen peroxide is available, it should either be used between operations (total processing time usually 65 minutes before re-entering in the OR). Spatial separationIn general, a given OR should only be used for SARS-CoV-2</PlainText></TextGroup> patients.</Pgraph><SubHeadline>Operation of ventilation systems</SubHeadline><Pgraph>No evidence is available upon which to base a risk assessment of ventilation systems, but the following conclusions can be drawn from the results of the assessment of different room airflow patterns:</Pgraph><Pgraph><UnorderedList><ListItem level="1">ORs with laminar air flow (LAF) (in Germany room class Ia) have a significantly larger ventilation volume flow than operating theaters with mixed ventilation (in Germany room class Ib), which means that aerosol dilution in the operating room with LAF ventilation proceeds considerably faster. In operating rooms with LAF, additional protection for the surgical team and the patient is ensured by the directed instead of only mixed ventilation in the operating area. If the exhaust air from the OR flows directly to the outside via the exhaust-air device, the OR can be used without restrictions. The usual protective measures would be sufficient in the OR.<LineBreak></LineBreak>However, if the neighboring rooms are ventilated with the “exhaust air” from the operating room using overflow technology, contamination of these rooms cannot be ruled out. Since this air is highly diluted and considering that in these operating theater concepts the supply corridor is excessively ventilated, we consider a general exclusion to be incommensurate. In such a case, we recommend an individual risk assessment.</ListItem><ListItem level="1">If the ventilation system can be switched to negative pressure, this ensures that no viruses from the operating room can infiltrate neighboring rooms by overflow. But opening doors immediately interrupts the negative pressure and allows air exchange with the surroundings. Therefore, the doors must be kept closed during the entire operation. </ListItem><ListItem level="1">Due to the mixed flow and the significantly lower ventilation volume with swirling of aerosols, operations in class Ib rooms pose a higher risk of contamination to the surgical team. It is questionable whether the FFP3 mask ensures a seal tight enough to exclude putting the team at risk. In this event, protection of the surgical team can be achieved by wearing overpressure body exhaust suits <TextLink reference="5"></TextLink>.</ListItem><ListItem level="1">ORs or intervention rooms of class II rooms with mechanical turbulent ventilation also have an air exchange rate and often are not equipped with sterile filters. Therefore, they are also not acceptable for surgery on COVID-19 patients.</ListItem><ListItem level="1">ORs without mechanical ventilation are also not acceptable, since released aerosols are not diluted and the highest aerosol concentration emerges through the opened doors at the end of the operation.</ListItem></UnorderedList></Pgraph></TextBlock> <TextBlock linked="yes" name="Notes"> <MainHeadline>Notes</MainHeadline><SubHeadline>Competing interests</SubHeadline><Pgraph>The authors declare that they have no competing interests.</Pgraph></TextBlock> <References linked="yes"> <Reference refNo="1"> <RefAuthor>Zou L</RefAuthor> <RefAuthor>Ruan F</RefAuthor> <RefAuthor>Huang M</RefAuthor> <RefAuthor>Liang L</RefAuthor> <RefAuthor>Huang H</RefAuthor> <RefAuthor>Hong Z</RefAuthor> <RefAuthor>Yu J</RefAuthor> <RefAuthor>Kang M</RefAuthor> <RefAuthor>Song Y</RefAuthor> <RefAuthor>Xia J</RefAuthor> <RefAuthor>Guo Q</RefAuthor> <RefAuthor>Song T</RefAuthor> <RefAuthor>He J</RefAuthor> <RefAuthor>Yen HL</RefAuthor> <RefAuthor>Peiris M</RefAuthor> <RefAuthor>Wu J</RefAuthor> <RefTitle>SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients</RefTitle> <RefYear>2020</RefYear> <RefJournal>N Engl J Med</RefJournal> <RefPage>1177-9</RefPage> <RefTotal>Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, Yu J, Kang M, Song Y, Xia J, Guo Q, Song T, He J, Yen HL, Peiris M, Wu J. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med. 2020 03;382(12):1177-9. DOI: 10.1056/NEJMc2001737</RefTotal> <RefLink>https://doi.org/10.1056/NEJMc2001737</RefLink> </Reference> <Reference refNo="2"> <RefAuthor>Judson SD</RefAuthor> <RefAuthor>Munster VJ</RefAuthor> <RefTitle>Nosocomial Transmission of Emerging Viruses via Aerosol-Generating Medical Procedures</RefTitle> <RefYear>2019</RefYear> <RefJournal>Viruses</RefJournal> <RefPage></RefPage> <RefTotal>Judson SD, Munster VJ. Nosocomial Transmission of Emerging Viruses via Aerosol-Generating Medical Procedures. Viruses. 2019 Oct;11(10):. DOI: 10.3390/v11100940</RefTotal> <RefLink>https://doi.org/10.3390/v11100940</RefLink> </Reference> <Reference refNo="3"> <RefAuthor>Kampf G</RefAuthor> <RefAuthor>Todt D</RefAuthor> <RefAuthor>Pfaender S</RefAuthor> <RefAuthor>Steinmann E</RefAuthor> <RefTitle>Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents</RefTitle> <RefYear>2020</RefYear> <RefJournal>J Hosp Infect</RefJournal> <RefPage>246-51</RefPage> <RefTotal>Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020 Mar;104(3):246-51. DOI: 10.1016/j.jhin.2020.01.022</RefTotal> <RefLink>https://doi.org/10.1016/j.jhin.2020.01.022</RefLink> </Reference> <Reference refNo="4"> <RefAuthor>Wang W</RefAuthor> <RefAuthor>Xu Y</RefAuthor> <RefAuthor>Gao R</RefAuthor> <RefAuthor></RefAuthor> <RefTitle>Detection of SARS-CoV-2 in different types of clinical specimens</RefTitle> <RefYear>2020</RefYear> <RefJournal>JAMA</RefJournal> <RefPage>1843-4</RefPage> <RefTotal>Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843-4. DOI: 10.1001/jama.2020.3786</RefTotal> <RefLink>https://doi.org/10.1001/jama.2020.3786</RefLink> </Reference> <Reference refNo="5"> <RefAuthor>Makovicka JL</RefAuthor> <RefAuthor>Bingham JS</RefAuthor> <RefAuthor>Patel KA</RefAuthor> <RefAuthor>Young SW</RefAuthor> <RefAuthor>Beauchamp CP</RefAuthor> <RefAuthor>Spangehl MJ</RefAuthor> <RefTitle>Surgeon Personal Protection: An Underappreciated Benefit of Positive-pressure Exhaust Suits</RefTitle> <RefYear>2018</RefYear> <RefJournal>Clin Orthop Relat Res</RefJournal> <RefPage>1341-8</RefPage> <RefTotal>Makovicka JL, Bingham JS, Patel KA, Young SW, Beauchamp CP, Spangehl MJ. Surgeon Personal Protection: An Underappreciated Benefit of Positive-pressure Exhaust Suits. Clin Orthop Relat Res. 2018 06;476(6):1341-8. DOI: 10.1007/s11999.0000000000000253</RefTotal> <RefLink>https://doi.org/10.1007/s11999.0000000000000253</RefLink> </Reference> </References> <Media> <Tables> <NoOfTables>0</NoOfTables> </Tables> <Figures> <NoOfPictures>0</NoOfPictures> </Figures> <InlineFigures> <NoOfPictures>0</NoOfPictures> </InlineFigures> <Attachments> <NoOfAttachments>0</NoOfAttachments> </Attachments> </Media> </OrigData> </GmsArticle>