TY  - CHAP
T1  - Urinary tract infections in children with chronic kidney disease
T2  - Urogenital Infections and Inflammations
AU  - Kilis-Pstrusinska, Katarzyna
ED  - Naber, Kurt G.
AD  - Professor Katarzyna Kilis-Pstrusinska PhD, MD, Wroclaw Medical University, Department of Pediatric Nephrology, Borowska 213, 50-556, Wroclaw, Polen, Phone: +48 717364400, +48 717364413, E-mail: katarzyna.kilis-pstrusinska@umed.wroc.pl
N2  - Studies concerning urinary tract infection (UTI) in children with chronic kidney disease (CKD) are scarce. In CKD children a wide variety of underlying predisposing factors for UTI may be considered, such as age, gender, genetic factors, urinary obstruction, bladder, and bowel dysfunction, bladder catheterization, nephrolithiasis, altered local, and systemic immune status, frequent hospitalizations, and sexual activity in adolescents. General rules of UTI management in CKD children are similar to those used in children without CKD. However, there are some important peculiarities. Common symptoms of UTI may be mimicked by conditions typical for CKD (also post-transplant). Results of laboratory tests concerning detection of pathogenic microorganisms and an inflammatory response in the urinary tract may be misleading because of uremic environment. The aim of UTI treatment must involve not only rapid recovery from complaints, elimination of pathogenic microorganisms from urinary tract, prevention of related complications, but also the prevention of further impairment of kidney function. Dosage of drugs should be adjusted to the estimated glomerular filtration (eGFR) rate, calculated from the current serum creatinine and body length according to the Schwartz formula. Nephrotoxic drugs are contraindicated. Treatment of asymptomatic bacteriuria generally is not recommended, however it should be considered in same cases. Studies on pathophysiological mechanisms of UTI in children with different stages of CKD are needed. Future research should also concern optimization of UTI therapy in order to preserve renal function. 
PY  - 2018
DA  - 2018/11/26
DO  - 10.5680/lhuii000045
LA  - en
L1  - https://books.publisso.de/de/system/getFile/166
UR  - https://dx.doi.org/10.5680/lhuii000045
L2  - https://dx.doi.org/10.5680/lhuii000045
PB  - German Medical Science GMS Publishing House
CY  - Berlin
ER  -