TY  - CHAP
T1  - Urinary tract infections in patients with renal insufficiency and dialysis – epidemiology, pathogenesis, clinical symptoms, diagnosis and treatment
T2  - Urogenital Infections and Inflammations
AU  - Scherberich, Jürgen E.
AU  - Fünfstück, Reinhard
AU  - Naber, Kurt G.
ED  - Naber, Kurt G.
AD  - Prof. Dr. med. habil. Reinhard Fünfstück Prof. Dr., Sophien-und Hufeland-Klinikum Weimar/Gesundheitszentrum Weimar, Internal medicine, Friedrich-Engels-Strasse 43, 07749 , Jena, Deutschland, Phone: 0049 3641 396926  / 0049 173 2010424, E-mail: r.fuenfstueck@klinikum-weimar.de
N2  - Epidemiological studies show an increasing number of patients worldwide suffering from chronic kidney diseases (CKD), which are associated with a risk for progression to end-stage kidney disease (ESKD). CKD patients stage 2–5, patients with regular chronic dialysis treatment (hemo- or peritoneal dialysis), and patients suffering from kidney allograft dysfunction are at high risk to develop infections, e.g. urinary tract infections (UTI) and/or sepsis (urosepsis). These groups show metabolic disturbance, chronic inflammation, and impaired immunocompetence. Escherichia coli is still the most common pathogen in UTI. A wide variety of other pathogens may be involved in UTI. Urological interventions, catheterization, as well as repeated courses of antibiotics contribute to an increased challenge of antimicrobial resistance. The diagnosis of UTI in CKD is based on standard clinical and laboratory criteria. Pyuria (≥10 leucocytes/µl) is more often observed in patients with oligoanuria and low bacterial colony counts. The treatment strategies for this population are based on the same principles as in patients with normal renal function. However, drugs cleared by the kidney or by dialysis membranes need dose adjustment. Antimicrobials with potential systemic toxicity and nephrotoxicity should be administered with caution. 
PY  - 2021
DA  - 2021/12/21
DO  - 10.5680/lhuii000068
LA  - en
L1  - https://books.publisso.de/de/system/getFile/789
UR  - https://dx.doi.org/10.5680/lhuii000068
L2  - https://dx.doi.org/10.5680/lhuii000068
KW  - urinary tract infection
KW  - pyuria
KW  - pyelonephritis
KW  - bacterial interstitial nephritis
KW  - chronic renal failure
KW  - end-stage kidney disease
KW  - renal replacement therapy
KW  - risk profiles
KW  - antibiotic therapy
KW  - microbial resistance
PB  - German Medical Science GMS Publishing House
CY  - Berlin
ER  -