TY - CHAP T1 - Biomarkers in children with kidney diseases T2 - Urogenital Infections and Inflammations AU - Ciuntu, Angela AU - Bernic, Jana ED - Naber, Kurt G. AD - Professor Angela Ciuntu MD,PhD, Nicolae Testemitanu State University of Medicine and Pharmacy, Department of Pediatrics, Stefan cel Mare si Sfant, 165, 2004, Chisinau, Republik Moldau, Phone: 37379842912, E-mail: angela.ciuntu@usmf.md N2 - Novel biomarkers are used to facilitate the early diagnosis, timely treatment, and prognosis of renal pathology in children. Technological progress on the one hand and a remarkable clinical significance of biomarkers on the other hand are subjects of scientific and clinical value. In spite of marked progress in this field, sensitivity and specificity of novel biomarkers represent a concern that is still prevailing. Furthermore, the identification of a perfect biomarker is of particular importance and faces a number of issues: organ specificity; secretion after cell injury; early production after a reversible organ injury; proportional extent of cell injury; appropriate use as a treatment-monitoring tool, with a quick reduction in response to effective treatment; and easy and prompt assessment. Discovery of biomarkers is a subject of special interest. They emphasize the issues related to the incidence of urinary tract infections (UTI), idiopathic nephrotic syndrome (INS) and acute kidney injury (AKI). In addition, studies are conducted to identify specific markers for chronic kidney disease (CKD), facilitate a well-timed diagnosis and treatment, and improve patients’ outcome. PY - 2021 DA - 2021/11/24 DO - 10.5680/lhuii000060 LA - en L1 - https://books.publisso.de/de/system/getFile/784 UR - https://dx.doi.org/10.5680/lhuii000060 L2 - https://dx.doi.org/10.5680/lhuii000060 PB - German Medical Science GMS Publishing House CY - Berlin ER -