TY - CHAP T1 - Bacteriophage therapy of urinary tract infections T2 - Urogenital Infections and Inflammations AU - Perepanova, Tamara ED - Naber, Kurt G. AD - Tamara Perepanova, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology, 3-ja Parkovaja st, h. 51, Moscow, Russland, Phone: +74991647735, E-mail: perepanova2003@mail.ru N2 - The search for antibiotic alternatives, due to the growing level of antibiotic resistant microorganisms against the background of a decrease in the development and introduction of new antibiotics, draws our attention to bacteriophages (phages). The chapter briefly presents the history of bacteriophage therapy (phage therapy), the principles of phage treatment, modern knowledge about genetically engineered phages, phage lytic proteins – lysine and endolysins. Prospects of using phages in treatment of biofilm infection and joint use of phages and antibiotics are given. The mechanisms of resistance of bacteria to phages, the kinetics of phages in the human body during oral and rectal administration are described. Studies on the clinical use of phages are given, the problems of phage therapy and further prospects for the use of phages are discussed. PY - 2021 DA - 2021/09/07 DO - 10.5680/lhuii000067 LA - en L1 - https://books.publisso.de/de/system/getFile/745 UR - https://dx.doi.org/10.5680/lhuii000067 L2 - https://dx.doi.org/10.5680/lhuii000067 KW - urinary tract infection KW - bacteriophages KW - bacteriophage therapy KW - antibiotic resistance PB - German Medical Science GMS Publishing House CY - Berlin ER -