TY  - CHAP
T1  - Microbiology and resistance in urogenital tuberculosis
T2  - Urogenital Infections and Inflammations
AU  - Bonkat, Gernot
AU  - Francisco, N. M.
AU  - Müller, G.
AU  - Braissant, O.
ED  - Naber, Kurt G.
AD  - PD Dr. med. Gernot Bonkat, University Basel, alta uro AG, Merian Iselin Klinik, Center of Biomechanics & Calorimetry (COB), Centralbahnplatz 6, 4051, Basel, Schweiz, Phone: 0041 61 226 3000, E-mail: bonkat@alta-uro.com
N2  - Mycobacteria are less common than other infections but still represent a significant threat to patients. Their slow growing nature and the late appearance of symptoms of urogenital mycobacterial infections often result in a delayed diagnostic and more severe consequences. UGTB is mostly linked to an active or inactive lung tuberculosis, as a consequence a similar immune response is expected. Unfortunately, compared to TB, very little is known on specific response to urinary tract infection caused by MOTT, still knowledge from BCG instillation for bladder cancer treatment suggest a similar process as well. With respect to treatment and drug resistance, considering the late onset of symptoms, the potentially large populations of mycobacteria in some lesion and their mutation rate, monotherapy should be avoided. Such monotherapy would mostly lead to the emergence of resistant subpopulations. In addition, some studies focusing on persisters emphasize that at least PZA and RIF should be included in the treatment regimen as those drugs have shown some activity on persisters.
PY  - 2018
DA  - 2018/05/17
DO  - 10.5680/lhuii000033
LA  - en
L1  - https://books.publisso.de/de/system/getFile/141
UR  - https://dx.doi.org/10.5680/lhuii000033
L2  - https://dx.doi.org/10.5680/lhuii000033
PB  - German Medical Science GMS Publishing House
CY  - Duesseldorf
ER  -