TY - CHAP T1 - Urogenital tuberculosis as a part of extrapulmonary tuberculosis in two epidemic regions T2 - Urogenital Infections and Inflammations AU - Kulchavenya, Ekaterina AU - Merganov, Mahmadzarif ED - Naber, Kurt G. AD - Prof Ekaterina Kulchavenya, Novosibirsk Research TB Institute, Novosibirsk State Medical University, Novosibirsk, Russland, E-mail: ku_ekaterina@mail.ru N2 - Introduction: The role of extrapulmonary tuberculosis (EPTB) in general and urogenital tuberculosis (UGTB) in particular is under-estimated in official statistics, medical practice and by the population. The purpose of this report was to estimate the relative importance of UGTB in the spectrum of EPTB in two epidemic regions of central Asia (Siberia, Russian Federation, and the Republic of Tajikistan) and its relation to human immunodeficiency virus (HIV) comorbidity, age and sex. Material and Methods: A retrospective descriptive report based on official statistics from the tuberculosis dispensaries (special outpatient clinics) of Siberia and Tajikistan for 2018 was made. Results: In Siberia the most common form was bone and joint tuberculosis (BJTB) – 43.6%, followed by urogenital tuberculosis (UGTB) – 21.3%, and tuberculosis of the central nervous system (CNS-TB) – 17.0%. In Tajikistan the leading localization was also BJTB (46.0%), followed by tuberculosis of peripheral lymph nodes (LNTB) – 27.7%, whereas the percentage of UGTB was only 6.1%. Patients combining EPTB and HIV infection were 36.8% in Siberia but only 3.5% in Tajikistan. CNS-TB was the predominating localization in patients with HIV infection in Siberia (38.3%), while in Tajikistan LNTB and BJTB (37.9% and 31.0%, respectively) were the most common sites. UGTB was the rarest form among HIV-infected patients reported in both regions. In Siberia CNS-TB was detected twice as often in men than in women (67.9% versus 32.1%) and a similar proportion was described for BJTB (62.9% versus 37.1% ). In Tajikistan female patients predominated among CNS-TB (71.4%), LNTB (81.5%), and abdominal tuberculosis (68.9%). UGTB equally often affected men and women in both regions. Conclusions: HIV-comorbidity significantly changes the spectrum of EPTB. UGTB had a negative correlation with HIV infection. Spectrum of EPTB is variable from region to region. The different sex-age relationships with EPTB in the two regions cannot be explained. PY - 2020 DA - 2020/11/18 DO - 10.5680/lhuii000058 LA - en L1 - https://books.publisso.de/de/system/getFile/554 UR - https://dx.doi.org/10.5680/lhuii000058 L2 - https://dx.doi.org/10.5680/lhuii000058 KW - extrapulmonary tuberculosis KW - epidemiology KW - incidence KW - urogenital tuberculosis KW - bone and joints tuberculosis KW - HIV + EPTB comorbidity PB - German Medical Science GMS Publishing House CY - Berlin ER -